ID A7SEC4_NEMVE Unreviewed; 578 AA.
AC A7SEC4;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 24-JAN-2024, entry version 74.
DE RecName: Full=Beta-galactosidase {ECO:0008006|Google:ProtNLM};
GN ORFNames=NEMVEDRAFT_v1g169627 {ECO:0000313|EMBL:EDO37927.1};
OS Nematostella vectensis (Starlet sea anemone).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Edwardsiidae; Nematostella.
OX NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO37927.1, ECO:0000313|Proteomes:UP000001593};
RN [1] {ECO:0000313|EMBL:EDO37927.1, ECO:0000313|Proteomes:UP000001593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX PubMed=17615350; DOI=10.1126/science.1139158;
RA Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA Technau U., Martindale M.Q., Rokhsar D.S.;
RT "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT genomic organization.";
RL Science 317:86-94(2007).
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 35 family.
CC {ECO:0000256|ARBA:ARBA00009809}.
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DR EMBL; DS469636; EDO37927.1; -; Genomic_DNA.
DR RefSeq; XP_001629990.1; XM_001629940.1.
DR AlphaFoldDB; A7SEC4; -.
DR STRING; 45351.A7SEC4; -.
DR EnsemblMetazoa; EDO37927; EDO37927; NEMVEDRAFT_v1g169627.
DR eggNOG; KOG0496; Eukaryota.
DR HOGENOM; CLU_007853_7_2_1; -.
DR InParanoid; A7SEC4; -.
DR OMA; VWGDLHH; -.
DR PhylomeDB; A7SEC4; -.
DR Proteomes; UP000001593; Unassembled WGS sequence.
DR GO; GO:0005773; C:vacuole; IBA:GO_Central.
DR GO; GO:0004565; F:beta-galactosidase activity; IBA:GO_Central.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 2.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR InterPro; IPR026283; B-gal_1-like.
DR InterPro; IPR048912; BetaGal1-like_ABD1.
DR InterPro; IPR048913; BetaGal_gal-bd.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR031330; Gly_Hdrlase_35_cat.
DR InterPro; IPR019801; Glyco_hydro_35_CS.
DR InterPro; IPR001944; Glycoside_Hdrlase_35.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR PANTHER; PTHR23421:SF199; BETA-GALACTOSIDASE; 1.
DR PANTHER; PTHR23421; BETA-GALACTOSIDASE RELATED; 1.
DR Pfam; PF21317; BetaGal_ABD_1; 1.
DR Pfam; PF21467; BetaGal_gal-bd; 1.
DR Pfam; PF01301; Glyco_hydro_35; 1.
DR PIRSF; PIRSF006336; B-gal; 1.
DR PRINTS; PR00742; GLHYDRLASE35.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR PROSITE; PS01182; GLYCOSYL_HYDROL_F35; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000001593}.
FT DOMAIN 2..297
FT /note="Glycoside hydrolase 35 catalytic"
FT /evidence="ECO:0000259|Pfam:PF01301"
FT DOMAIN 360..462
FT /note="Beta-galactosidase 1-like first all-beta"
FT /evidence="ECO:0000259|Pfam:PF21317"
FT DOMAIN 488..547
FT /note="Beta-galactosidase galactose-binding"
FT /evidence="ECO:0000259|Pfam:PF21467"
FT ACT_SITE 128
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR006336-1"
FT ACT_SITE 201
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR006336-1"
SQ SEQUENCE 578 AA; 66199 MW; 40F1B9D7930FB790 CRC64;
MPEYWADRLK KLKAMGLNTV ETYVAWNLHE QVKENFKFKD EVDIVKFVNL AQELGLHVII
RPGPYICSEW DLGGLPSWLL NDPNMRLRST YGPFMEAVEK YFSKLFALLT PLQFSRGGPI
IAWQVENEYA SVQEEVDNHY MELLHKLMLK NGATELLFTS DDVGYTKRYP IKLDGGKYMS
FNKWFCLFLH FQPDKPIMVT EYWSGWFDHW GEKHHVLNTE RKMINEVKDI LDMGASINFY
MFHGGTNFGF MNGANTAGNR IDDGYQPDVT SYDYDAPLSE AGDITPKYKA LRKLIQEHVP
GEFLPDPLPD IPPNLQKAAY DNIHMKDFVP LQKIYKYIDQ AIDIAAVTPM EFLPINNNGG
QGYGFTIYQT TLKHHAKSLT IEKIRDRAHV SFLYKSNADV VDEIVFTVNP KDSDDDVFLE
IMVENMGRVN FGKGLHSQRK GILGQVLIDG HTQNKWKVYP LDFHKTFTER AFLEVSWSKP
TEGASFSPGF YRGILHIQGQ PRDSFVHPKG WGKGVCLVNG KNLGRYWKLG PQEALYLPAS
WLRSGDNTII LFEVDGAKDD GILEFSDSPM LGNDIQEQ
//
