ID A7SG53_NEMVE Unreviewed; 729 AA.
AC A7SG53;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 27-MAR-2024, entry version 85.
DE RecName: Full=Latrophilin Cirl {ECO:0000256|ARBA:ARBA00015543};
GN ORFNames=NEMVEDRAFT_v1g211772 {ECO:0000313|EMBL:EDO37335.1};
OS Nematostella vectensis (Starlet sea anemone).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Edwardsiidae; Nematostella.
OX NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO37335.1, ECO:0000313|Proteomes:UP000001593};
RN [1] {ECO:0000313|EMBL:EDO37335.1, ECO:0000313|Proteomes:UP000001593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX PubMed=17615350; DOI=10.1126/science.1139158;
RA Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA Technau U., Martindale M.Q., Rokhsar D.S.;
RT "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT genomic organization.";
RL Science 317:86-94(2007).
CC -!- SUBUNIT: Forms a heterodimer, consisting of a large extracellular
CC region non-covalently linked to a seven-transmembrane moiety.
CC {ECO:0000256|ARBA:ARBA00011834}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; DS469649; EDO37335.1; -; Genomic_DNA.
DR RefSeq; XP_001629398.1; XM_001629348.1.
DR AlphaFoldDB; A7SG53; -.
DR STRING; 45351.A7SG53; -.
DR EnsemblMetazoa; EDO37335; EDO37335; NEMVEDRAFT_v1g211772.
DR eggNOG; KOG4193; Eukaryota.
DR HOGENOM; CLU_380055_0_0_1; -.
DR InParanoid; A7SG53; -.
DR OMA; CRASDIN; -.
DR PhylomeDB; A7SG53; -.
DR Proteomes; UP000001593; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR CDD; cd15040; 7tmB2_Adhesion; 1.
DR CDD; cd00037; CLECT; 1.
DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR000203; GPS.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR12011:SF347; LATROPHILIN CIRL; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF00059; Lectin_C; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00034; CLECT; 1.
DR SMART; SM00303; GPS; 1.
DR SUPFAM; SSF56436; C-type lectin-like; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001593};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 485..504
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 525..549
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 569..592
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 613..632
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 644..667
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 458..666
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 688..729
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 692..707
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 729 AA; 80340 MW; 3184FF10222D3209 CRC64;
MTNKCYLVNN DKVKLFHEAQ NNCSKLGGQL FVEPDKEKWK SLFSEISGWS VGSKYYVGIK
KNEDFVWQWL DKTPALIDGS GPCAYINFSL YSINTVSGSE TCNMGYICQK EPEVPSSSEI
YTATTSNITT SLANAATTAA AALRIAATTP TPITTRAATT ERTTSTTAIW TATTTTAPPA
TYDTSIITSA TRTSTSARKS TAVTRTPAIT KIITVTTTKT VTKTIMVTNT IATATTSTFS
LPKINNLIQD LIQQPKNVSF EEAVVVVDNI TSLLNEPQID SSLAISTLMN ASRAFEKFAA
EYGAKHLNET SPRIYKVSSG INVLLQKVFK PKHARDFEFN YTNTINELTI QANIPWQNID
NGAVILAVVF KNFKRTLLST SSIDRSLDSH VLSLVLHPNP RSVLKKNVTM TFDHNSKDKI
FTGEVQRSCV FWKFTTSSPS YSGSWSTDGC TAVSSDNHVT TCSCNHLTNF AILMQVTPKP
PVVCVTAAAM LQLFLMAALF WMLLEGIQLY LQLVRVYNAD MNLKLCYIFA WGIPVLVVGI
SLAVVAGSAR GIESYTQLKA CWISYNYHVA WTFVVPAAFV IVINGSIFFR ILKELSNMSQ
RQQRAQESYS IVRNLKACLV LFPILGITWS IGFVNMLDAG VVTMYLFTIL NSTQGLLIFI
LHCALNLEMR AAFRGKLCRE SQVKDFSSSH SHKKTQGQSS IPTPSKTKGV ELQLEDADPG
DLPDTNNTY
//
