ID   A7SGA7_NEMVE            Unreviewed;       544 AA.
AC   A7SGA7;
DT   02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT   02-OCT-2007, sequence version 1.
DT   27-MAR-2024, entry version 55.
DE   RecName: Full=Fibronectin type-III domain-containing protein {ECO:0000259|PROSITE:PS50853};
GN   ORFNames=NEMVEDRAFT_v1g211838 {ECO:0000313|EMBL:EDO37305.1};
OS   Nematostella vectensis (Starlet sea anemone).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Edwardsiidae; Nematostella.
OX   NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO37305.1, ECO:0000313|Proteomes:UP000001593};
RN   [1] {ECO:0000313|EMBL:EDO37305.1, ECO:0000313|Proteomes:UP000001593}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX   PubMed=17615350; DOI=10.1126/science.1139158;
RA   Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA   Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA   Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA   Technau U., Martindale M.Q., Rokhsar D.S.;
RT   "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT   genomic organization.";
RL   Science 317:86-94(2007).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; DS469650; EDO37305.1; -; Genomic_DNA.
DR   RefSeq; XP_001629368.1; XM_001629318.1.
DR   AlphaFoldDB; A7SGA7; -.
DR   STRING; 45351.A7SGA7; -.
DR   EnsemblMetazoa; EDO37305; EDO37305; NEMVEDRAFT_v1g211838.
DR   KEGG; nve:5508785; -.
DR   HOGENOM; CLU_037255_0_0_1; -.
DR   InParanoid; A7SGA7; -.
DR   PhylomeDB; A7SGA7; -.
DR   Proteomes; UP000001593; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0034220; P:monoatomic ion transmembrane transport; IEA:UniProtKB-KW.
DR   CDD; cd00063; FN3; 1.
DR   Gene3D; 1.10.287.70; -; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013099; K_chnl_dom.
DR   PANTHER; PTHR11537:SF252; POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAW; 1.
DR   PANTHER; PTHR11537; VOLTAGE-GATED POTASSIUM CHANNEL; 1.
DR   Pfam; PF00041; fn3; 1.
DR   Pfam; PF07885; Ion_trans_2; 1.
DR   SUPFAM; SSF49265; Fibronectin type III; 1.
DR   SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR   PROSITE; PS50853; FN3; 1.
PE   4: Predicted;
KW   Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001593};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        201..229
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        241..262
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        274..294
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        451..469
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          1..78
FT                   /note="Fibronectin type-III"
FT                   /evidence="ECO:0000259|PROSITE:PS50853"
SQ   SEQUENCE   544 AA;  62347 MW;  4503DC625F36D8D0 CRC64;
     MEKLMGYRIT YRPISIGDEV VRNRPWKNIT VRKDKQTTFV IKDLINYVKY EFRVTGFTRG
     GDGPHEAANG ETCHCYKRVA ANYRIFPPYV IASLGLTSVN MSGMIPEILR NLTVSCCRTC
     RQHGQSYVDF FRNGQGGPSY HTNEKEVQNL IDNNNDLSFP VYGYQSQIVY EGIYRFIPLV
     ESPGFAFLVK EPDKINAFRE IMLSVLGTWP CLLLTVLMAL LAGIVMWMLD TTANPEHFPT
     TVVSGFWNGW WWAFISMTTL GYGDRVPLTN RARVFTIVWV LIGLVIFSIL SGTITSAFTS
     IVFESATGIY GTKIATLSDT PEYRFAARRQ ARVNIDQNYT RFLDVVEALM SRSVEGVLID
     AYEAGTKKKD LAGTGVRIQK VYDYKSTYGV VLSGPSVRLY KCSRNYMTAY KADMYTHIQK
     FVQVVEADAY DEVIELSTGL FDKDTQAFKD LLFYSLIVMG AFWFLGLLWE LRRFLMNRKV
     EEGYEALEAK KKMESELREF ANSFYEDLKE TITSMRQRHK QERLQLLRQM PKSAKSTLAR
     ELKA
//