ID   A7SH25_NEMVE            Unreviewed;       719 AA.
AC   A7SH25;
DT   02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT   02-OCT-2007, sequence version 1.
DT   27-MAR-2024, entry version 88.
DE   RecName: Full=Ketosynthase family 3 (KS3) domain-containing protein {ECO:0000259|PROSITE:PS52004};
DE   Flags: Fragment;
GN   ORFNames=NEMVEDRAFT_v1g70130 {ECO:0000313|EMBL:EDO36949.1};
OS   Nematostella vectensis (Starlet sea anemone).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Edwardsiidae; Nematostella.
OX   NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO36949.1, ECO:0000313|Proteomes:UP000001593};
RN   [1] {ECO:0000313|EMBL:EDO36949.1, ECO:0000313|Proteomes:UP000001593}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX   PubMed=17615350; DOI=10.1126/science.1139158;
RA   Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA   Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA   Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA   Technau U., Martindale M.Q., Rokhsar D.S.;
RT   "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT   genomic organization.";
RL   Science 317:86-94(2007).
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DR   EMBL; DS469657; EDO36949.1; -; Genomic_DNA.
DR   RefSeq; XP_001629012.1; XM_001628962.1.
DR   AlphaFoldDB; A7SH25; -.
DR   STRING; 45351.A7SH25; -.
DR   EnsemblMetazoa; EDO36949; EDO36949; NEMVEDRAFT_v1g70130.
DR   eggNOG; KOG1202; Eukaryota.
DR   HOGENOM; CLU_000022_16_6_1; -.
DR   InParanoid; A7SH25; -.
DR   OMA; CMDITEM; -.
DR   PhylomeDB; A7SH25; -.
DR   UniPathway; UPA00094; -.
DR   Proteomes; UP000001593; Unassembled WGS sequence.
DR   GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd00833; PKS; 1.
DR   Gene3D; 3.40.47.10; -; 1.
DR   Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR   InterPro; IPR001227; Ac_transferase_dom_sf.
DR   InterPro; IPR014043; Acyl_transferase.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR018201; Ketoacyl_synth_AS.
DR   InterPro; IPR014031; Ketoacyl_synth_C.
DR   InterPro; IPR014030; Ketoacyl_synth_N.
DR   InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR   InterPro; IPR032821; PKS_assoc.
DR   InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR   PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR   Pfam; PF00698; Acyl_transf_1; 1.
DR   Pfam; PF16197; KAsynt_C_assoc; 1.
DR   Pfam; PF00109; ketoacyl-synt; 1.
DR   Pfam; PF02801; Ketoacyl-synt_C; 1.
DR   SMART; SM00827; PKS_AT; 1.
DR   SMART; SM00825; PKS_KS; 1.
DR   SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR   SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR   SUPFAM; SSF53901; Thiolase-like; 1.
DR   PROSITE; PS00606; KS3_1; 1.
DR   PROSITE; PS52004; KS3_2; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000001593}.
FT   DOMAIN          3..436
FT                   /note="Ketosynthase family 3 (KS3)"
FT                   /evidence="ECO:0000259|PROSITE:PS52004"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:EDO36949.1"
FT   NON_TER         719
FT                   /evidence="ECO:0000313|EMBL:EDO36949.1"
SQ   SEQUENCE   719 AA;  78423 MW;  9D83B40D88EB54BD CRC64;
     NERKTVSLIG IGCRFPLAPN KNEFWKMLQQ GRCAVSSFPE NRSNEYENFR SLYHPKRFVT
     GRICTLGGAY MDNIRGFDTA FFKISQQEAN SMDPQQRILL EVVYEAIEDS GMTIEDLQAC
     RTGVFVGVMN LDYGVLVTDK NNIKNMDQFV ATGVTGSIVS NRISFCFNFT GPSFTVDTAC
     SSSLTAFKLA IDNLQNGDCE AAIVCAPNLI LSEIMHMTNS LAGLLAPDGR CKSFDASGDG
     YGRGEGFAAV VLKLTETALT DGDDIYSEVL ACGLNNDGAD TVPMTAPSSR SQAKLFRMVL
     ERSGLQAKDV DYVEAHGTGT AIGDVVETTS ISEAYCESIP HHSRVLRVGS VKSNLNHTES
     TSGLAGLIKL ALMIKNQSYV PTINVHTLNP RLKLAEKGLM IQTVAERWER RDGKPRIGAV
     SSYGFGGSNA HTILREINSS SESSSLSSSQ TATHVLTLSA RCKDSLRGAA QSIAKWLTEH
     EDLRLGLYDI CYSLNERRTL HSHRIAISCE TTDEVIKLLN DFAQDNKGWE KKVTYGVSRE
     ESQKLVFMFG GQGPQWYGMG KQLIENEPKF LKTILEVGKL LKEMGEGWDL VNELNASEEN
     SRLQELVIGQ TATFALQYAI ARLLISWGIY PSAVIGHSLG EFAASVVAGA LSLKDALSVV
     LLRAKLQERC PSNGAMAALG MSKEEAHSLL EELKLENTLS IAAVNDAKSV TLSGDRDSI
//