ID A7SHW0_NEMVE Unreviewed; 412 AA.
AC A7SHW0;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 08-NOV-2023, entry version 78.
DE RecName: Full=Transmembrane prolyl 4-hydroxylase {ECO:0008006|Google:ProtNLM};
GN ORFNames=NEMVEDRAFT_v1g212518 {ECO:0000313|EMBL:EDO36694.1};
OS Nematostella vectensis (Starlet sea anemone).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Edwardsiidae; Nematostella.
OX NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO36694.1, ECO:0000313|Proteomes:UP000001593};
RN [1] {ECO:0000313|EMBL:EDO36694.1, ECO:0000313|Proteomes:UP000001593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX PubMed=17615350; DOI=10.1126/science.1139158;
RA Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA Technau U., Martindale M.Q., Rokhsar D.S.;
RT "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT genomic organization.";
RL Science 317:86-94(2007).
CC -!- COFACTOR:
CC Name=L-ascorbate; Xref=ChEBI:CHEBI:38290;
CC Evidence={ECO:0000256|ARBA:ARBA00001961};
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DR EMBL; DS469663; EDO36694.1; -; Genomic_DNA.
DR RefSeq; XP_001628757.1; XM_001628707.1.
DR AlphaFoldDB; A7SHW0; -.
DR EnsemblMetazoa; EDO36694; EDO36694; NEMVEDRAFT_v1g212518.
DR eggNOG; KOG1591; Eukaryota.
DR HOGENOM; CLU_035319_0_0_1; -.
DR InParanoid; A7SHW0; -.
DR OMA; SWINVDP; -.
DR PhylomeDB; A7SHW0; -.
DR Proteomes; UP000001593; Unassembled WGS sequence.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0031418; F:L-ascorbic acid binding; IEA:InterPro.
DR GO; GO:0004656; F:procollagen-proline 4-dioxygenase activity; IBA:GO_Central.
DR Gene3D; 2.60.120.620; q2cbj1_9rhob like domain; 2.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR005123; Oxoglu/Fe-dep_dioxygenase.
DR InterPro; IPR045054; P4HA-like.
DR InterPro; IPR006620; Pro_4_hyd_alph.
DR InterPro; IPR044862; Pro_4_hyd_alph_FE2OG_OXY.
DR PANTHER; PTHR10869; PROLYL 4-HYDROXYLASE ALPHA SUBUNIT; 1.
DR PANTHER; PTHR10869:SF230; TRANSMEMBRANE PROLYL 4-HYDROXYLASE; 1.
DR Pfam; PF13640; 2OG-FeII_Oxy_3; 1.
DR SMART; SM00702; P4Hc; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS51471; FE2OG_OXY; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Dioxygenase {ECO:0000256|ARBA:ARBA00022964};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000001593}.
FT DOMAIN 65..100
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 243..395
FT /note="Fe2OG dioxygenase"
FT /evidence="ECO:0000259|PROSITE:PS51471"
SQ SEQUENCE 412 AA; 47415 MW; 018225B69915A7C8 CRC64;
MITRAMKPTI LEIPNFLSPD ECDHIIELAK VSGLAQSVAG FDKEAYQGGL DRELDAVDET
KPAAGPDDLL AERFDTWDKN NDGMIDMDEI SSFALKYDKL YLNRDEVMEM LDKLKFQEPE
KCQISLAEFE SRGIKKLLTY LWYLKDKHPR HRPRYSEQAW LPVERTADRM LRSIQDRIKK
LTKLPEKLIR TSESIQVVRY VMVMCHVFHV ALNVTVTCHV FQVVRYVTIT CHVFHVLRYV
MVTCHVFQVV RYGEGGHYHG HLDSTPTTNR EIPCCHQNVL NKPECKLCRF ITILYYLNDV
DEGGETAFVV ADNETYTIDE SLQDPQHSSD EFNLSSNCHK ATLVIPPKRG TAVMWYNHVM
DPVSGLLGEV DHFSFHGGCD IKRGVKWIAN NWINAPTSQS EHIRSIYDLT DT
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