ID A7SNS8_NEMVE Unreviewed; 1459 AA.
AC A7SNS8;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 27-MAR-2024, entry version 87.
DE RecName: Full=Sushi domain-containing protein {ECO:0000259|PROSITE:PS50923};
DE Flags: Fragment;
GN ORFNames=NEMVEDRAFT_v1g10113 {ECO:0000313|EMBL:EDO34671.1};
OS Nematostella vectensis (Starlet sea anemone).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Edwardsiidae; Nematostella.
OX NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO34671.1, ECO:0000313|Proteomes:UP000001593};
RN [1] {ECO:0000313|EMBL:EDO34671.1, ECO:0000313|Proteomes:UP000001593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX PubMed=17615350; DOI=10.1126/science.1139158;
RA Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA Technau U., Martindale M.Q., Rokhsar D.S.;
RT "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT genomic organization.";
RL Science 317:86-94(2007).
CC -!- SIMILARITY: Belongs to the peptidase M43B family.
CC {ECO:0000256|ARBA:ARBA00008721}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DS469723; EDO34671.1; -; Genomic_DNA.
DR RefSeq; XP_001626771.1; XM_001626721.1.
DR STRING; 45351.A7SNS8; -.
DR EnsemblMetazoa; EDO34671; EDO34671; NEMVEDRAFT_v1g10113.
DR eggNOG; ENOG502QQ7Z; Eukaryota.
DR HOGENOM; CLU_002636_2_0_1; -.
DR InParanoid; A7SNS8; -.
DR OMA; KQVVCEP; -.
DR PhylomeDB; A7SNS8; -.
DR Proteomes; UP000001593; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0004222; F:metalloendopeptidase activity; IBA:GO_Central.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0006508; P:proteolysis; IBA:GO_Central.
DR CDD; cd00033; CCP; 3.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 4.10.470.20; -; 1.
DR Gene3D; 3.40.390.10; Collagenase (Catalytic Domain); 1.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR006558; LamG-like.
DR InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR InterPro; IPR011936; Myxo_disulph_rpt.
DR InterPro; IPR000800; Notch_dom.
DR InterPro; IPR043543; PAPPA/PAPPA2.
DR InterPro; IPR008754; Peptidase_M43.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR NCBIfam; TIGR02232; myxo_disulf_rpt; 1.
DR PANTHER; PTHR46130; LAMGL DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46130:SF3; SUSHI DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF13385; Laminin_G_3; 1.
DR Pfam; PF00066; Notch; 1.
DR Pfam; PF05572; Peptidase_M43; 1.
DR Pfam; PF00084; Sushi; 3.
DR SMART; SM00032; CCP; 5.
DR SMART; SM00560; LamGL; 1.
DR SMART; SM00004; NL; 2.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 4.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
DR PROSITE; PS50923; SUSHI; 2.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000001593};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Sushi {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT DOMAIN 1142..1200
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1272..1326
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EDO34671.1"
FT NON_TER 1459
FT /evidence="ECO:0000313|EMBL:EDO34671.1"
SQ SEQUENCE 1459 AA; 163036 MW; E9DA7D89E6CC33DE CRC64;
VKIPSREFTI EFWVRPEGGQ HSPVPILGLY DLCSSESKDR GWRIGLVEKA PEKSVRLFYS
LRTARSNRNT TLLSDRRVEP HHWVHVAGTY DGRYMKFYIN QAKVGVSSDQ KGHVFASPLI
SESCEVIEAG GERRMLTYFR GSIDQVKFWS VPRTHKEISE EVFGKKTNPA NLIFVEDFSG
IGNKILSWLT ITETAPEIVE STIPSDKHDL ALVRPPCGST VCDNPEVVRS YVNNTHLRQH
KTLRFRVINV MNDDGSDPIV SKAQIRHQTK TLNDAFSVWN ITWEMHEVEV RNTSLRGKTV
LFMCSPSEIG DMRCNKDYCN LPITGYDGGD CIEGGYNKCD PAKRGNGQCD PECNRHDHAW
DYGDCCDPSI TLTDKTCFDP TSLYRAYLSL KEYKELLNFD NARFLNVYFK QCGDNCDETF
QGTATFPWEN TVHSVLGGVL INPGYFGQKG HSNSIIHEFG HALGLWHVHR GVTELKCTDE
CHETFPSMEL GDLCSDTNPT PLNKKCRDPA LKRNDMVCGR KYFRDTPFRN YMSYADDSCT
NSFTPQQAAR MHCYADFIFQ SWQAQKTGPS FIPIPPRVTS ETPGSVSIAW IPPLGTGGAN
AMNMCHLCAK DDILEQYAVT AFSPIKENRP NGYWAPQQAL GAPDAKRCVL DPKAWNPMQK
APRSCPNCYI ELGFKEAIIP TELSIWVTWH PKNGISDIWL IFFDGTHESL GNATAQCDSP
LTMAVRTHKK VVRVRIYTYT SIDAVKLTSS VSHPNCRRCK PVHYLVSRDP PFLDGQEQVT
KTTGLRDSSV KQGQSYTYTV RAVTSSGLKS PPSPPLTYTP KRGFCGDGRV DEKAGEECDD
GNVRDGDGCN MQCKKEDVFH CEGHPSLCYR HDGDGVCEEF ERMYSIRDCG FYTPEGFLDQ
WARNASANPD YQLPECPASR VIGPPVRDLV CKPDPDLSVA WAPCGHYFAD SDYWLQVTFE
HAVVPAAVLV YLASDGRAGP AYDEFVKTIE VDLYDTEGNI HESGSKEVSL SCKTNPAVVH
IRHDMTMKFY YSRKVRLTSK SYMVAIAGVT LRSLTSLDPV ALAGCGPDEL YNPRTQRCHK
YNCDKPKCPP LLVKRATVKC EGDKEGQRCV VTCAKGYRPR RPFKMLCLHG KWRGAVDKCV
PVDCGIPKIP NAKANCPKGT KFGSTCVFRC VPNAKMTGLE HSITCEDDGK WSAQQSFCIM
TCAVPPIPPN ALAISGTCIG EKGKYKAWVS CKFRCKTRFR LQVSKDAPSK KVLKVRCTKE
GTWTLNSHCV PITCPAPPPY LRYWYNCTHG DAMGSLCTSS CPDAKSHQIK CGGNGYWSSP
FMKCKTAGSC GVPPQIPGLK FTCSAYSLKA TCKVTCTAKN YDAVVKVIRV GKEDIWGVSI
ACDSKLKWEP DPMLITCLKE CRKDIGDGWC DEKNNNQHCR WDGGDCCAST TKDRMVRRSP
PHCGKACDCL DPSALENRR
//
