ID A7SNU1_NEMVE Unreviewed; 223 AA.
AC A7SNU1;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE RecName: Full=MBD domain-containing protein {ECO:0000259|PROSITE:PS50982};
GN ORFNames=NEMVEDRAFT_v1g125309 {ECO:0000313|EMBL:EDO34622.1};
OS Nematostella vectensis (Starlet sea anemone).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Edwardsiidae; Nematostella.
OX NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO34622.1, ECO:0000313|Proteomes:UP000001593};
RN [1] {ECO:0000313|EMBL:EDO34622.1, ECO:0000313|Proteomes:UP000001593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX PubMed=17615350; DOI=10.1126/science.1139158;
RA Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA Technau U., Martindale M.Q., Rokhsar D.S.;
RT "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT genomic organization.";
RL Science 317:86-94(2007).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; DS469724; EDO34622.1; -; Genomic_DNA.
DR RefSeq; XP_001626722.1; XM_001626672.1.
DR AlphaFoldDB; A7SNU1; -.
DR STRING; 45351.A7SNU1; -.
DR EnsemblMetazoa; EDO34622; EDO34622; NEMVEDRAFT_v1g125309.
DR eggNOG; KOG4161; Eukaryota.
DR HOGENOM; CLU_069710_2_0_1; -.
DR InParanoid; A7SNU1; -.
DR OMA; MLMGKMN; -.
DR PhylomeDB; A7SNU1; -.
DR Proteomes; UP000001593; Unassembled WGS sequence.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProt.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0008327; F:methyl-CpG binding; IBA:GO_Central.
DR GO; GO:0006346; P:DNA methylation-dependent heterochromatin formation; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR016177; DNA-bd_dom_sf.
DR InterPro; IPR025884; MeCpG-bd_2/3_C_dom.
DR InterPro; IPR001739; Methyl_CpG_DNA-bd.
DR PANTHER; PTHR12396:SF0; METHYL-CPG BINDING DOMAIN PROTEIN-LIKE, ISOFORM C; 1.
DR PANTHER; PTHR12396; METHYL-CPG BINDING PROTEIN, MBD; 1.
DR Pfam; PF01429; MBD; 1.
DR Pfam; PF14048; MBD_C; 1.
DR SUPFAM; SSF54171; DNA-binding domain; 1.
DR PROSITE; PS50982; MBD; 1.
PE 4: Predicted;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001593}.
FT DOMAIN 3..87
FT /note="MBD"
FT /evidence="ECO:0000259|PROSITE:PS50982"
FT REGION 68..87
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EDO34622.1"
SQ SEQUENCE 223 AA; 24996 MW; AE89221CE941D705 CRC64;
MEEKPVRVTC PSLPKGWLRE IVLRKSGVSA GRSDVYYYSD SSGMGPTALG QTILPRRSQP
NFSRDLNGAI PNSPVRQSTK SFSKQPVSYY PGRQAKKQKV EPIKTKIDKE KPKQLFWEKR
IQGLTAVNAE DERKLDAFNL GKTFRVIGPG MDEKALVHAL VTNIHTKSSI KGQSMSLVAL
EKHPEIWINV DQPPCAPFVI TDADIKAQEE RVSRQRQKLA EAI
//
