ID A7SR35_NEMVE Unreviewed; 569 AA.
AC A7SR35;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE RecName: Full=glycine dehydrogenase (aminomethyl-transferring) {ECO:0000256|ARBA:ARBA00012134};
DE EC=1.4.4.2 {ECO:0000256|ARBA:ARBA00012134};
GN ORFNames=NEMVEDRAFT_v1g173380 {ECO:0000313|EMBL:EDO33822.1};
OS Nematostella vectensis (Starlet sea anemone).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Edwardsiidae; Nematostella.
OX NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO33822.1, ECO:0000313|Proteomes:UP000001593};
RN [1] {ECO:0000313|EMBL:EDO33822.1, ECO:0000313|Proteomes:UP000001593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX PubMed=17615350; DOI=10.1126/science.1139158;
RA Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA Technau U., Martindale M.Q., Rokhsar D.S.;
RT "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT genomic organization.";
RL Science 317:86-94(2007).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=glycine + H(+) + N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage
CC complex H protein] = CO2 + N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-
CC L-lysyl-[glycine-cleavage complex H protein]; Xref=Rhea:RHEA:24304,
CC Rhea:RHEA-COMP:10494, Rhea:RHEA-COMP:10495, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:57305, ChEBI:CHEBI:83099,
CC ChEBI:CHEBI:83143; EC=1.4.4.2;
CC Evidence={ECO:0000256|ARBA:ARBA00043839};
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933};
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DR EMBL; DS469755; EDO33822.1; -; Genomic_DNA.
DR RefSeq; XP_001625922.1; XM_001625872.1.
DR AlphaFoldDB; A7SR35; -.
DR STRING; 45351.A7SR35; -.
DR EnsemblMetazoa; EDO33822; EDO33822; NEMVEDRAFT_v1g173380.
DR eggNOG; KOG2040; Eukaryota.
DR HOGENOM; CLU_004620_5_2_1; -.
DR InParanoid; A7SR35; -.
DR OMA; MHINLHK; -.
DR PhylomeDB; A7SR35; -.
DR Proteomes; UP000001593; Unassembled WGS sequence.
DR GO; GO:0005960; C:glycine cleavage complex; IBA:GO_Central.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0016594; F:glycine binding; IBA:GO_Central.
DR GO; GO:0004375; F:glycine dehydrogenase (decarboxylating) activity; IBA:GO_Central.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IBA:GO_Central.
DR GO; GO:0019464; P:glycine decarboxylation via glycine cleavage system; IBA:GO_Central.
DR CDD; cd00613; GDC-P; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR049316; GDC-P_C.
DR InterPro; IPR049315; GDC-P_N.
DR InterPro; IPR020581; GDC_P.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR PANTHER; PTHR11773:SF1; GLYCINE DEHYDROGENASE (DECARBOXYLATING), MITOCHONDRIAL; 1.
DR PANTHER; PTHR11773; GLYCINE DEHYDROGENASE, DECARBOXYLATING; 1.
DR Pfam; PF21478; GcvP2_C; 1.
DR Pfam; PF02347; GDC-P; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000001593}.
FT DOMAIN 79..334
FT /note="Glycine cleavage system P-protein N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02347"
FT DOMAIN 384..502
FT /note="Glycine dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21478"
SQ SEQUENCE 569 AA; 62972 MW; C20AF30FD04DD174 CRC64;
MIARAAERKI NLRKYSDDKV GVSLDETVKE QDLDDLLWVF GCDSKAAEVG THLAEVPYKS
LLNSPFKRLS SFLTHPVFNT HHAETNVVRY MKLLENKDIS LVHSMIPLGS CTMKLNSTTE
MMPITWPRFA DIHPYAPIQQ AKGYLQLYDE FEKDVCEITG FDAVCFQPNS GAQGEYTGLR
VIKAYLENNG QGHRKVCLIP VSAHGNNPAS AQMAGFNVQV IKVGKSGDID MEDLKKQVEK
FSDELACIMV TYPSTNGIFE AGIRDICDIV HYHGGQVYLD GANLNAQVGL CRPADYGADV
MHSNLHKTFC IPHGGGGPGM GPIGVKKHLI SYLPSHPVVP PQSTIAAGAK PFGVISGAPY
GSSAILPISW AYIKLMGGKG LRKATEVAIL NAYYMAARLK DYYAVFVGDG YCAHEFILDA
KDYKKTGVEA MDIAKRLQDY GFHAPTVSWP VSTALMIEPT ESESKAELDR LCDALICIRE
EIRNIEDGVW DPKNNPLKNA PHPQAVVMSD HWDYPYSREV AAFPAPWLNG TNKFWPGCSR
VDDKHGDQHL VCTCPPLEDY DYEKTKTFV
//
