ID A7SRI8_NEMVE Unreviewed; 347 AA.
AC A7SRI8;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE RecName: Full=DH domain-containing protein {ECO:0000259|PROSITE:PS50010};
GN ORFNames=NEMVEDRAFT_v1g128857 {ECO:0000313|EMBL:EDO33665.1};
OS Nematostella vectensis (Starlet sea anemone).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Edwardsiidae; Nematostella.
OX NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO33665.1, ECO:0000313|Proteomes:UP000001593};
RN [1] {ECO:0000313|EMBL:EDO33665.1, ECO:0000313|Proteomes:UP000001593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX PubMed=17615350; DOI=10.1126/science.1139158;
RA Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA Technau U., Martindale M.Q., Rokhsar D.S.;
RT "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT genomic organization.";
RL Science 317:86-94(2007).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; DS469763; EDO33665.1; -; Genomic_DNA.
DR RefSeq; XP_001625765.1; XM_001625715.1.
DR AlphaFoldDB; A7SRI8; -.
DR STRING; 45351.A7SRI8; -.
DR EnsemblMetazoa; EDO33665; EDO33665; NEMVEDRAFT_v1g128857.
DR GeneID; 5504909; -.
DR KEGG; nve:5504909; -.
DR eggNOG; KOG3520; Eukaryota.
DR HOGENOM; CLU_003962_0_0_1; -.
DR InParanoid; A7SRI8; -.
DR OMA; QPENPRN; -.
DR OrthoDB; 2875542at2759; -.
DR PhylomeDB; A7SRI8; -.
DR Proteomes; UP000001593; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041020; PH_16.
DR PANTHER; PTHR45872; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 2, ISOFORM D; 1.
DR PANTHER; PTHR45872:SF2; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 2, ISOFORM D; 1.
DR Pfam; PF17838; PH_16; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001593}.
FT DOMAIN 13..202
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EDO33665.1"
SQ SEQUENCE 347 AA; 40459 MW; 31FAB4290DA2BAF5 CRC64;
RQTIKKLKQK EIKRQEFIHE LIYTEKTHVR NLKVLDKVFH KPMKKMNIMP YEYIKKLFPN
LQELIEIHGD LLQSMKKREA EGEVIQCIGD IMLNRFDNEA GEAAKQACAT FCNYQKNALE
ELRQRQKKDP KLLQFIMNCE ASPLCRRLKL NEIISTSYQR LTKYPLLLEG IGKNTPSSLP
DSRDIERAIQ CAKDLLAFVN QSVKECENQQ RLEEFQKKVD RKPMDSATNK QMEEFKTLDF
SKKKLIYDGP LTWRISRTKS IDLHVLLLED LLVILQKQDD RLVLKCHSTN MTTGYQEKTT
HSPIIKLNNV LTRNVATDKR AFFLVGTSSV GPQIYELVAA TITERKK
//
