ID A7SRP2_NEMVE Unreviewed; 491 AA.
AC A7SRP2;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE RecName: Full=Sulfatase N-terminal domain-containing protein {ECO:0000259|Pfam:PF00884};
GN ORFNames=NEMVEDRAFT_v1g173586 {ECO:0000313|EMBL:EDO33632.1};
OS Nematostella vectensis (Starlet sea anemone).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Edwardsiidae; Nematostella.
OX NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO33632.1, ECO:0000313|Proteomes:UP000001593};
RN [1] {ECO:0000313|EMBL:EDO33632.1, ECO:0000313|Proteomes:UP000001593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX PubMed=17615350; DOI=10.1126/science.1139158;
RA Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA Technau U., Martindale M.Q., Rokhsar D.S.;
RT "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT genomic organization.";
RL Science 317:86-94(2007).
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00001913};
CC -!- SIMILARITY: Belongs to the sulfatase family.
CC {ECO:0000256|ARBA:ARBA00008779}.
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DR EMBL; DS469765; EDO33632.1; -; Genomic_DNA.
DR RefSeq; XP_001625732.1; XM_001625682.1.
DR AlphaFoldDB; A7SRP2; -.
DR STRING; 45351.A7SRP2; -.
DR EnsemblMetazoa; EDO33632; EDO33632; NEMVEDRAFT_v1g173586.
DR GeneID; 5504846; -.
DR KEGG; nve:5504846; -.
DR eggNOG; KOG3867; Eukaryota.
DR HOGENOM; CLU_006332_10_1_1; -.
DR InParanoid; A7SRP2; -.
DR OMA; YPGIVKQ; -.
DR OrthoDB; 2913702at2759; -.
DR PhylomeDB; A7SRP2; -.
DR Proteomes; UP000001593; Unassembled WGS sequence.
DR GO; GO:0008484; F:sulfuric ester hydrolase activity; IEA:UniProt.
DR CDD; cd16029; 4-S; 1.
DR Gene3D; 3.30.1120.10; -; 1.
DR Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR InterPro; IPR047115; ARSB.
DR InterPro; IPR024607; Sulfatase_CS.
DR InterPro; IPR000917; Sulfatase_N.
DR PANTHER; PTHR10342; ARYLSULFATASE; 1.
DR PANTHER; PTHR10342:SF275; SULFATASE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00884; Sulfatase; 1.
DR SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
DR PROSITE; PS00523; SULFATASE_1; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000001593};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..491
FT /note="Sulfatase N-terminal domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002715263"
FT DOMAIN 25..332
FT /note="Sulfatase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00884"
FT REGION 466..491
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 491 AA; 55335 MW; AF9E4EC79B48A7A9 CRC64;
MGVRLSFHCF FLCLNVVVLQ SSAKPHLLFV LADDLGWSDV GFHGSKIQTP NIDRLAANGV
ILDNYYVQPV CTPTRASLMT GKYPIHTGLQ HGIIHNGRPY GLPLNLTLLP QKLRKAGYST
HMLGKWHLGF YNWESTPTYR GFDTFYGFYS GAENHYTHVQ DHYLDLRDNE EIVRDQNGTY
SAHLFTKRAE QIVRAHDPST PLFMYMAFQN VHSPVQAPKE YIDRYSFIKD PLRRTYAAMV
TIMDDALGNL TRAFDKAGLW ENTILIFSTD NGGVPKNGGY DYPLRGRKDT LWEGGVRGVA
FVHGVALEQS GVKCKALMHV TDWYPTLVSL AGGSLDEDED LDGYDVWESI SHGVESPRKE
LLHNIDTINI PPGDGSLGFS TTGIGLRVGD MKLLMAVPNI SYFIPPEDRN GSVDWYIHSN
NKVPMVEVAL YNITADPYEK HDLHDKLPDV VTRLQLRVEH YRKTAVPPAN KPKDPYARQV
AKQNGAWTPW V
//
