ID A7SSB3_NEMVE Unreviewed; 552 AA.
AC A7SSB3;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=HRDC domain-containing protein {ECO:0000259|PROSITE:PS50967};
DE Flags: Fragment;
GN ORFNames=NEMVEDRAFT_v1g129645 {ECO:0000313|EMBL:EDO33428.1};
OS Nematostella vectensis (Starlet sea anemone).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Edwardsiidae; Nematostella.
OX NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO33428.1, ECO:0000313|Proteomes:UP000001593};
RN [1] {ECO:0000313|EMBL:EDO33428.1, ECO:0000313|Proteomes:UP000001593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX PubMed=17615350; DOI=10.1126/science.1139158;
RA Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA Technau U., Martindale M.Q., Rokhsar D.S.;
RT "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT genomic organization.";
RL Science 317:86-94(2007).
CC -!- SIMILARITY: Belongs to the exosome component 10/RRP6 family.
CC {ECO:0000256|ARBA:ARBA00043957}.
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DR EMBL; DS469774; EDO33428.1; -; Genomic_DNA.
DR RefSeq; XP_001625528.1; XM_001625478.1.
DR AlphaFoldDB; A7SSB3; -.
DR STRING; 45351.A7SSB3; -.
DR eggNOG; KOG2206; Eukaryota.
DR HOGENOM; CLU_010129_4_3_1; -.
DR InParanoid; A7SSB3; -.
DR OMA; NIMRPQM; -.
DR PhylomeDB; A7SSB3; -.
DR Proteomes; UP000001593; Unassembled WGS sequence.
DR GO; GO:0000176; C:nuclear exosome (RNase complex); IBA:GO_Central.
DR GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR GO; GO:0000175; F:3'-5'-RNA exonuclease activity; IBA:GO_Central.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0003727; F:single-stranded RNA binding; IBA:GO_Central.
DR GO; GO:0000467; P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR GO; GO:0071044; P:histone mRNA catabolic process; IBA:GO_Central.
DR GO; GO:0071040; P:nuclear polyadenylation-dependent antisense transcript catabolic process; IBA:GO_Central.
DR GO; GO:0071039; P:nuclear polyadenylation-dependent CUT catabolic process; IBA:GO_Central.
DR GO; GO:0071035; P:nuclear polyadenylation-dependent rRNA catabolic process; IBA:GO_Central.
DR GO; GO:0071036; P:nuclear polyadenylation-dependent snoRNA catabolic process; IBA:GO_Central.
DR GO; GO:0071037; P:nuclear polyadenylation-dependent snRNA catabolic process; IBA:GO_Central.
DR GO; GO:0071038; P:nuclear polyadenylation-dependent tRNA catabolic process; IBA:GO_Central.
DR GO; GO:0071051; P:polyadenylation-dependent snoRNA 3'-end processing; IBA:GO_Central.
DR CDD; cd06147; Rrp6p_like_exo; 1.
DR Gene3D; 1.10.150.80; HRDC domain; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR InterPro; IPR012588; Exosome-assoc_fac_Rrp6_N.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR002121; HRDC_dom.
DR InterPro; IPR044876; HRDC_dom_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR045092; Rrp6-like.
DR InterPro; IPR049559; Rrp6p-like_exo.
DR PANTHER; PTHR12124:SF47; EXOSOME COMPONENT 10; 1.
DR PANTHER; PTHR12124; POLYMYOSITIS/SCLERODERMA AUTOANTIGEN-RELATED; 1.
DR Pfam; PF01612; DNA_pol_A_exo1; 1.
DR Pfam; PF00570; HRDC; 1.
DR Pfam; PF08066; PMC2NT; 1.
DR SMART; SM00474; 35EXOc; 1.
DR SMART; SM00341; HRDC; 1.
DR SUPFAM; SSF47819; HRDC-like; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50967; HRDC; 1.
PE 3: Inferred from homology;
KW Exosome {ECO:0000256|ARBA:ARBA00022835};
KW Reference proteome {ECO:0000313|Proteomes:UP000001593};
KW rRNA processing {ECO:0000256|ARBA:ARBA00022552}.
FT DOMAIN 465..545
FT /note="HRDC"
FT /evidence="ECO:0000259|PROSITE:PS50967"
FT NON_TER 552
FT /evidence="ECO:0000313|EMBL:EDO33428.1"
SQ SEQUENCE 552 AA; 64070 MW; 3ABCF9E565B5B205 CRC64;
LVGGIQKANS LPEAGEDHDF YYSFSDFREF RKAQGTRILN NVHDLLKQFH VRCRWPNRNT
SCSNVDVDDL YESLVEANDT LLEEVDTSLD EASGLSKNRK PILSPAVRQG GPMVSSWNRK
TRDNNNKDGN FRLLLAKNIQ RPQMKFKDKI DNSNTPFIPI IKYKPNALKP LDQGLASRGR
GQEVQNPEDL SVPSVIADFI HQQRVNSASE NPVNRISHPY EFELQRFEPP ATQLKEAKEQ
LYDSLEDTPF TLVETVEQLE SLSQKLMEAQ EFAVDLEHHS YRSFLGFVCL MQISTRDHDF
LVDTLELRND LHLLNESFTN PNILKVFHGA DMDVGWLQRD FGIYVVNMFD TGQASRVLAL
ERFSLAFLLK KFCGVTADKQ YQLADWRIRP LPEEMIRYAR EDTHYLLYIH DRLRNELIRT
GNENNNLLLS VYSRSTEVCQ KHYEKPLFTS ESYMNLYTKQ RRPLNPVQLR AFRALYAWRD
TIARREDESY GYVLPNHMLF TIAETLPREP QGVLACCNPV PTLVKQYVNE VHQLILQSRD
ASTTVRLRRY TL
//
