ID A7SVI9_NEMVE Unreviewed; 4953 AA.
AC A7SVI9;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=EGF-like domain-containing protein {ECO:0000259|PROSITE:PS01186};
GN ORFNames=NEMVEDRAFT_v1g218117 {ECO:0000313|EMBL:EDO32273.1};
OS Nematostella vectensis (Starlet sea anemone).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Edwardsiidae; Nematostella.
OX NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO32273.1, ECO:0000313|Proteomes:UP000001593};
RN [1] {ECO:0000313|EMBL:EDO32273.1, ECO:0000313|Proteomes:UP000001593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX PubMed=17615350; DOI=10.1126/science.1139158;
RA Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA Technau U., Martindale M.Q., Rokhsar D.S.;
RT "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT genomic organization.";
RL Science 317:86-94(2007).
CC -!- SIMILARITY: Belongs to the EGF domain peptide family.
CC {ECO:0000256|ARBA:ARBA00006373}.
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DR EMBL; DS469837; EDO32273.1; -; Genomic_DNA.
DR RefSeq; XP_001624373.1; XM_001624323.1.
DR STRING; 45351.A7SVI9; -.
DR EnsemblMetazoa; EDO32273; EDO32273; NEMVEDRAFT_v1g218117.
DR eggNOG; KOG1306; Eukaryota.
DR HOGENOM; CLU_223372_0_0_1; -.
DR InParanoid; A7SVI9; -.
DR OMA; WDDDQTI; -.
DR PhylomeDB; A7SVI9; -.
DR Proteomes; UP000001593; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0007154; P:cell communication; IEA:InterPro.
DR GO; GO:0030001; P:metal ion transport; IBA:GO_Central.
DR CDD; cd00054; EGF_CA; 1.
DR Gene3D; 2.60.40.2030; -; 41.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR InterPro; IPR038081; CalX-like_sf.
DR InterPro; IPR003644; Calx_beta.
DR InterPro; IPR000742; EGF-like_dom.
DR PANTHER; PTHR11878:SF76; NA_CA EXCHANGERS; 1.
DR PANTHER; PTHR11878; SODIUM/CALCIUM EXCHANGER; 1.
DR Pfam; PF03160; Calx-beta; 42.
DR SMART; SM00237; Calx_beta; 39.
DR SUPFAM; SSF141072; CalX-like; 41.
DR PROSITE; PS01186; EGF_2; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001593};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 4893..4917
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4924..4943
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 2492..2503
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS01186"
SQ SEQUENCE 4953 AA; 531444 MW; 985E65F48167F1DD CRC64;
MYIAAFGIAM EIYQRKCSRY NTIYVYLTTF SFASSSYSVE EDTGYVTVNI TKTGTSDISL
DVKLSTNNGT AFSPVDYTAM SDNSVTFLAN EQSKLVNITI NVDQTVENDE DFKALLSHTN
ADQVALGLLN TTTITIGNDD QATFSFASSS YSVEEDTGYV TVNITKTGTS DISLDVKLST
NNGTAFSPVD YTAMSDNSVT FLANEQSKLV NITINVDQTV ENDEDFKALL SHTNADQVAL
GLLNTTTITI GNDDQATFSF ASSSYSVEED TGYVTVNITK TGTSDISLDV KLSTNNGTAF
SPVDYTAMSD NSVTFLANEQ SKLVNITINV DQTVENDEDF KALLSHTNAD QVALGLLNTT
TITIGNDDQA TFSFASSSYS VEEDTGYVTV NITKTGTSDI SLDVKLSTNN GTAFSPVDYT
AMSDNSVTFL ANEQSKLVNI TINVDQTVEN DEDFKALLSH TNADQVALGL LNTTTITIGN
DDQATFSFAS PSYSVEEDTG YVTVNITKTG TSDIYLDVKL STNNGTAFSP VDYTAMSDNS
VTFLANEQSK LVNITINVDQ TVENDEDFKA LLSHTNADQV ALGLLNTTTI TIGNDDQATF
SFASSSYSVE EDTGYVTVNI TKTGTSDISL DVKLSTNNGT AFSPVDYTAM SDNSVTFLAN
EQSKLVNITI NVDQTVENDE DFKALLSHTN ADQVALGLLN TTTITIGNDD QATFSFASSS
YSVEEDTGYV TVNITKTGTS DINLDVKLST NNGTAFSPVD YTAMSDNSVT FLANEQSKLV
NITINVDQTV ENDEDFKALL SHTNADQVAL GLLNTTTITI GNDDRATFSF ASSSYSVEED
TGYVTVNITK TGTSDIHLDV KLSTNNGSAF SPVDYTAMSD NSVTFLANEQ SKLVNITINV
DQTVENDEDF KALLSHTNGD QVALGLLNTT TITIGNDDQA TFSFASSSYS VEEDTGYVTV
NITKTGTSDI SLDVKLSTNN GTAFSPVDYT AMSDNSVTFL ANEQSKLVNI TINVDQTVEN
DEDFKALLSH TNADQVALGL LNTTTITIGN DDQATFSFAS SSYSVEEDTG YVTVNITKTG
TSDISLDVKL STNNGTAFSP VDYTAMSDNS VTFLANEQSK LVNITINVDQ TVENDEDFKA
LLSHTNADQV ALGLLNTTTI TIGNDDQATF SFVSSSYSVE EDTGYVSVNI TKTGTSDISL
DVKLSTNNGT AFSPVDYTAM SDNSVTFLAN EQSKLVNITI NVDQTVENDE DFKALLSHTN
ADQVALGLLN TTTITIGNDD QATFSFASSS YSVEEDTGYV TVNITKTGTS DISLDVKLST
NNGTAFSPVD YTAMSDNSVT FLANEQSKLV NITINVDQTV ENDEDFKALL SHTNADQVAL
GLLNTTTITI GNDDQATFSF VSSSYSVEED TGYVTVNITK TGTSDISLDV KLSTNNGTAF
SPVDYTAMSD NSVTFLANEQ SKLVNITINV DQTVENDEDF KALLSYTNAD QVALGLLNTT
TITIGNDDQA TFSFASSSFS VEEDTGYVTV NITKTGTSDI SLDVKLSTNN GTAFSPVDYT
AMSDNSVTFL ANEQSKLVNI TINVDQTVEN DEDFKALLSH TNADQVALGL LNTTTITIGN
DDQATFSFVS SSYSVEEDTG YVTVNITKTG TSDISLDVKL STNNGTAFSP VDYTAMSDNS
LTFLANEQSK LVNITINVDQ TVENDEDFKA LLSHTNADKV ALGLLNTTTI TIGNDDQVEE
DTGYVTVNIT KTGTSDISLD VKLSTNNGTA FSPVDYTAMS DNSVTFLANE QSKLVNITIN
VDQTVENDED FKALLSHTNA DQVALGLLNT TTITIGNDDQ ATFSFASSSY SVDEDTGYVT
VNITKTGTSD ISLDVKLSTN NGTAFSPVDY TAMSDNSVTF LANEQSKLVN ITINVDQTVE
NDEDFKALLS HTNADQVALG LLNTTTITIG NDDQATFSFA SSSYSVEEDT GYVTVNITKT
GTSDISLDVK LSTNNGTAFS PVDYTAMSDN SVTFLANEQS KLVNITINVD QTVENDEDFK
ALLSHTNADQ VALGLLNTTT ITIGNDDQAT FSFASSSYSV EEDTGYVTVN ITKTGTSDIS
LDVKLSTNNG TAFSPVDYTA MSDNSVTFLA NEQSKLVNIT INVDQTVENE EDFKALLSHT
NADQVALGLL NTTTITIGND DQATFSFASP SYSVEEDTGY VTVNITKTGT SDISLDVKLS
TNNGTAFSPV DYTAMSDNSV TFLANEQSKL VNITINVDQT VENDEDFKAL LSHTNADQVA
LGLLNTTTIT IGNDDQATFS FASPSYSVEE DTGYVTVNIT KTGTSDIHLD VKLSTNNGTA
FSPVDYTAMS DNSVTFLANE QSKLVNITIN VDQTVENDED FKALLSHTNA DQVALGLLNT
TTITIGNDDQ ATFSFASPSY SVEEDTGYVT VNITKTGTSD IHLDVNKNDI VDIRPNDTKD
AEGNPSEPPA DIVENLCPNE CSNHGNCSNS TCICEEGFTS LDCSLSINTV PELLGLSTNN
GTAFSPVDYT AMSDNSVTFL ANEQSKLVNI TINVDQTVEN DEDFKALLSH TNADQVALGL
LNTTTITIGN DDQATFSFAS SSYSVEEDTG YVTVNITKTG TSDISLDVKL STNNGTAFSP
VDYTAMSDNS VTFLANEQSK LVNITINVDQ TVENDEDFKA LLSHTNADQV ALGLLNTTTI
TIGNDDQATF SFASSSYSVE EDTGYVTVNI TKTGTSDISL DVKLSTNNGT AFSPVDYTAM
SDNSVTFLAN EQSKLVNITI NVDQTVENDE DFKALLSHTN ADQVALGLLN TTTITIGNDD
QATFSFASSS YSVEEDTGYV TVNITKTGTS DISLDVKLST NNGTAFSPVD YTAMSDNSVT
FLANEQSKLV NITINVDQTV ENDEDFKALL SHTNADQVAL GLLNTTTITI GNDDQATFSF
ASPSYSVEED TGYVTVNITK TGTSDIHLDV KLSTNNGTAF SPVDYTAMSD NSVTFLANEQ
SKLVNITINV DQTVENDEDF KALLSHTNAD QVALGLLNTT TITIGNDDQA TFSFASPSYS
VEEDTGYVTV NITKTGTSDI HLDVKLSTNN GTAFSPVDYT AMSDNSVTFL ANEQSKLVNI
TINVDQTVEN DEDFKALLSH TNADQVALGL LNTTTITIGN DDQATFSFAS SSYSVEEDTG
YVTVNITKTG TSDISLDVKL STNNGTAFSP VDYTAMSDNS VTFLANEQSK LVNITINVDQ
TVENEEDFKA LLSHTNADQV ALGLLNTTTI TIGNDDQATF SFASSSYSVE EDTGYVTVNI
TKTGTSDISL DVQLSTNNGT AFSPVDYTAM SDNSVTFLAN EQSKLVNITI NVDQTVENEE
DFKALLSHTN ADQVALGLLN TTTITIGNDD QATFSFASSS YSVEEDTGYV TVNITKTGTS
DIHLDVKLST NNGTAFSPVD YTAMSDNSVT FLANEQSKLV NITINVDQTV ENDEDFKALL
SHTNADQVAL GLLNTTTITI GNDDQATFSF ASPSYSVEED TGYVTVNITK TGTSEIHLDV
KLSTNNGTAF SPVDYTAMSD NSVTFLANEQ SKLVNITINV DQTVENDEDF KALLSHTNAD
QVALGLLNTT TITIGNDDQA TFSFASPSYS VEEDTGYVTV NITKTGTSEI HLDVKLSTNN
GTAFSPVDYT AMSDNSVTFL ANEQSKLVNI TINVDQTVEN DEDFKALLSH TNADQVALGL
LNTTTITIGN DDQATFSFVS SSYSVEEDTG YVTVNITKTG TSDISLDVKL STNNGTAFSP
VDYTAMSDNS VTFLANEQSK LVNITINVDQ TVENDEDFKA LLSHTNADQV ALGLLNTTTI
TIGNDDQATF SFASSSYSVE EDTGYVTVNI TKTGTSDISL DVKLSTNNGT AFSPVDYTAM
SDNSVTFLAN EQSKLVNITI NVDQTVENDE DFKALLSHTN ADQVALGLLN TTTITIGNDD
QATFSFASSS YSVEEDTGYV TVNITKTGTS EISLDVKLST NNGTAFSPVD YTAMSDNSVT
FLANEQSKLV NITINVDQTV ENNEDFKALL SHTNADQVAL GLLNTTTITI GNDDQAIFSF
ASSSYSVEED TGYVTVNITK TGSSDIPLNV ILGTMDGIAA SGSDYTEIAN VTITFATNKA
SQLMNITIGV DSSVENEETF QALLYNNNPS QVLLGTSATT VIITNDDKAI FSFAAASYSV
VEDTGYVTVT INKTGLTDVD LSVLLNTEDG TAVSPVDFTA LVNGTVNFPA NEPSLSVNIS
IIVDNKVENN ETFKALISSN NPSQVAIGLT SSTDLTIQND DMGSVSFNQT LFVVNEGDSA
LLVFTCSGNN EIDFNFRLSS TPGTATVTDY TLANDTSLTC APGVTTTTFS VPTVQDVMAE
TTESFIVSIS ANAGEPFNFI DRVATVSIID TVDKVNITIS ASTYTTNEEA GPVTVVIEKT
DNAEINISAR LFSSDITAIS SPGSPYQDYA NFSKSFIFAP NEIRKEFPIS IITDEYLEFD
ETFKLTLVSQ IPAKAMVQPN SNSVVTIRND DAVTLELVEN GVVLLSNETS VRFTVRLTGK
SLIPVNFTVY TSNVPSLTPR KKRDTWSIPP SVNGTTTFNV ELNVIQELAI SDRFFVLLET
DQAFVSVRGN KKLVVAVAKD KHATIGFSSG SYFVKEDQGY VTICLRKNGV INRDVIVKLN
TADRDATSGA DYVPVVNKTV TFFAILETYC FNVTINDDNI TEADEKFYVE LSKDPSDPDV
VLNNQRTTVT ITNDDQVLVA LKSPYKKKAK EGDLVEFTAY VVSGDHAAPL IVNLTTNRDD
TSTTSDSLDV EFPQTIIIPA NASSVTFAVK IKDDALVESD EIVTVTLVSG DLSRVTLHRN
DTATINIDDE ADRVADKNKK EKDKQDIVIR DQFLIILIVA VLIALLIFIG VIIFCCLIKI
KWSLGIACVV QCVSAWLTVQ VVPRGVKKYA PNP
//
