ID A7SXE3_NEMVE Unreviewed; 794 AA.
AC A7SXE3;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE RecName: Full=Ras-GAP domain-containing protein {ECO:0000259|PROSITE:PS50018};
GN ORFNames=NEMVEDRAFT_v1g218988 {ECO:0000313|EMBL:EDO31616.1};
OS Nematostella vectensis (Starlet sea anemone).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Edwardsiidae; Nematostella.
OX NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO31616.1, ECO:0000313|Proteomes:UP000001593};
RN [1] {ECO:0000313|EMBL:EDO31616.1, ECO:0000313|Proteomes:UP000001593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX PubMed=17615350; DOI=10.1126/science.1139158;
RA Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA Technau U., Martindale M.Q., Rokhsar D.S.;
RT "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT genomic organization.";
RL Science 317:86-94(2007).
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DR EMBL; DS469885; EDO31616.1; -; Genomic_DNA.
DR RefSeq; XP_001623716.1; XM_001623666.1.
DR AlphaFoldDB; A7SXE3; -.
DR STRING; 45351.A7SXE3; -.
DR EnsemblMetazoa; EDO31616; EDO31616; NEMVEDRAFT_v1g218988.
DR eggNOG; KOG2128; Eukaryota.
DR HOGENOM; CLU_353854_0_0_1; -.
DR InParanoid; A7SXE3; -.
DR PhylomeDB; A7SXE3; -.
DR Proteomes; UP000001593; Unassembled WGS sequence.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR CDD; cd05127; RasGAP_IQGAP_like; 1.
DR InterPro; IPR000593; RasGAP_C.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR024785; TORC_C.
DR PANTHER; PTHR14149:SF14; PATTERNED EXPRESSION SITE; 1.
DR PANTHER; PTHR14149; RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF; 1.
DR Pfam; PF00616; RasGAP; 1.
DR Pfam; PF03836; RasGAP_C; 1.
DR Pfam; PF12886; TORC_C; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000001593}.
FT DOMAIN 92..325
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT COILED 522..549
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 794 AA; 90817 MW; A9301C638B61F999 CRC64;
MQDPPVKTVR KFLHLLQHSD ADFEEELELQ KLRAQVVTDI RSNQQLENDL NLMDIKIGLL
VKNRITLQTN PTYLAKLIFA MPQSRTTKFM ESVVLTLYNY ASNAREEYLL LKLFETALRE
EIYSKVDQLQ EIITGNPTVI RMVVHFNRGA RGQSSLRELL EPLVNDVLNE RNLNINTNPL
DVYKGWVNQM ESETGQTSKL PYDVDPEQAL SHPEVREKIA MSMRNLIQAT DKFLNSIVQS
VEKIPYGMRY VAMTLRLALT EKFPNLSEEE IIKVVGNLVY YRYMNPAIVA PDAFDIVSIS
VERGLQPEQR RNLGTIAKLL QFAASNKMYA DENAHLSELN GYIAEAHKKF KKFFLDVSTV
EDPESRFNID EYTDVVLLTK PIIYISVQEI CDTHTLLLEH REEIAPDPND PLHELLDDLG
DAPNVADLIG AQADSAEEQA QQVASISKTE ISLTLTNKFE VPDDDDSDMR ALFVRLPLEG
LKRKIIRNLR MLESQGLVTI KNDYQDIVNA IAKDIRNQRR YRQRRRQERK KLNQTLDSLQ
TKTHFYEEQI DYYNQYIRVC LDNLSKKGKF IDVLSCRAVN VNGKYRMQHP NLSPLEMRLQ
QVQLYQNSPN NDFNMYGQVT TSSPQNQSPT ASTSMSPLFK NFPAAPMSPL EMNMKQMYIP
NNSPVQHQHH DQYGMRLPGA SIGASPRMQQ QAMSSSQSPG PYGFPGFLQY YMQSNRVPDL
IVTDANDESQ KLDFARDLSS AMQGMGGDMY NNDDLRVELD PLDMESLQML SGHGDAEVAD
QATEDQFRMD RLAG
//
