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Database: UniProt
Entry: A7T196_NEMVE
LinkDB: A7T196_NEMVE
Original site: A7T196_NEMVE 
ID   A7T196_NEMVE            Unreviewed;       761 AA.
AC   A7T196;
DT   02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT   02-OCT-2007, sequence version 1.
DT   24-JAN-2024, entry version 100.
DE   RecName: Full=HECT-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012485};
DE            EC=2.3.2.26 {ECO:0000256|ARBA:ARBA00012485};
GN   ORFNames=NEMVEDRAFT_v1g248474 {ECO:0000313|EMBL:EDO30268.1};
OS   Nematostella vectensis (Starlet sea anemone).
OC   Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC   Edwardsiidae; Nematostella.
OX   NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO30268.1, ECO:0000313|Proteomes:UP000001593};
RN   [1] {ECO:0000313|EMBL:EDO30268.1, ECO:0000313|Proteomes:UP000001593}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX   PubMed=17615350; DOI=10.1126/science.1139158;
RA   Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA   Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA   Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA   Technau U., Martindale M.Q., Rokhsar D.S.;
RT   "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT   genomic organization.";
RL   Science 317:86-94(2007).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC         [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC         cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC         EC=2.3.2.26; Evidence={ECO:0000256|ARBA:ARBA00000885};
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DR   EMBL; DS470092; EDO30268.1; -; Genomic_DNA.
DR   RefSeq; XP_001622368.1; XM_001622318.1.
DR   AlphaFoldDB; A7T196; -.
DR   STRING; 45351.A7T196; -.
DR   EnsemblMetazoa; EDO30268; EDO30268; NEMVEDRAFT_v1g248474.
DR   eggNOG; KOG0939; Eukaryota.
DR   HOGENOM; CLU_014403_0_0_1; -.
DR   InParanoid; A7T196; -.
DR   OMA; NLCIFGP; -.
DR   PhylomeDB; A7T196; -.
DR   Proteomes; UP000001593; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR   GO; GO:0043066; P:negative regulation of apoptotic process; IBA:GO_Central.
DR   GO; GO:0000209; P:protein polyubiquitination; IBA:GO_Central.
DR   CDD; cd00078; HECTc; 1.
DR   Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR   Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR   Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   InterPro; IPR017868; Filamin/ABP280_repeat-like.
DR   InterPro; IPR000569; HECT_dom.
DR   InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   PANTHER; PTHR11254:SF340; APOPTOSIS-RESISTANT E3 UBIQUITIN PROTEIN LIGASE 1; 1.
DR   PANTHER; PTHR11254; HECT DOMAIN UBIQUITIN-PROTEIN LIGASE; 1.
DR   Pfam; PF00632; HECT; 1.
DR   SMART; SM00119; HECTc; 1.
DR   SUPFAM; SSF81296; E set domains; 1.
DR   SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR   PROSITE; PS50194; FILAMIN_REPEAT; 1.
DR   PROSITE; PS50237; HECT; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000001593};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW   ECO:0000256|PROSITE-ProRule:PRU00104}.
FT   REPEAT          100..130
FT                   /note="Filamin"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT   DOMAIN          420..761
FT                   /note="HECT"
FT                   /evidence="ECO:0000259|PROSITE:PS50237"
FT   ACT_SITE        728
FT                   /note="Glycyl thioester intermediate"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ   SEQUENCE   761 AA;  86379 MW;  DEC44B8617E99E1E CRC64;
     MVPESKYRFH NRHCLAKKGL QIYLFGHYLQ PRFTKVKWEW QDPQVVGETL TFLLQIRHNY
     TPFTVKRTDI DIEIVHDGTP IACSLDFGGP GWQEMNRVKV TFTVRKSGDY NIAVLAMGEH
     ITGSPFAKVF LPGSVDPAKC TIIERSSILV LQQGVYSPLL VEARDVYGNL RSISNAEDLL
     KYKVHIKKIG GSDSIDPELF VDSENRSNNS LHIKLEDEGI FQGTVSYDGT PVNNGELTII
     SLNDSEWYAV EKNIDRHCYN VWYEAALLPY PLTGSNTPPS IGNGADVARK SRKVYCYISP
     RNVSIKEFYM RIFPHKLHAF RVSPRTKFTL HPPNSNYEHP AFTISDGAQA PVSVVCRDRN
     VLVATYSRLV LLNIGGSESF KKKREFFNEK LLSHQGMKGG EVRLKINRSN LLESSYVACK
     NVDWLKMFNV TFEGEEGLDW GGVRREWFEL LCIALFGRDS ELFTRFKGDD PQAPVHPNPR
     RPPHLNLKYY KFAGQVVSKC IYESAISNAR RQNVKAKFTR SFLAQLLGLR VNYKYLESDD
     KDLYRSKVQL IEKNDPADLE LKFTEEEYNS SGQLEKVVEL LPGGRLIDVT EQNKCEYLNL
     MARYKLVESV QKEVEAFIQG LNELVPDNLL GMFDENELEL LMCGTGHISV ADMKAHHHVL
     AGGGQRFTKI MDWFWTIVSS LTQEELARLL QFVTGSSQLP PGGFAELSPQ LQISYIATSQ
     ALPTAHTCFN QLCLPDFPSF NEMQRKLLLA VNEGCEGFGF S
//
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