ID A7T196_NEMVE Unreviewed; 761 AA.
AC A7T196;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 24-JAN-2024, entry version 100.
DE RecName: Full=HECT-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012485};
DE EC=2.3.2.26 {ECO:0000256|ARBA:ARBA00012485};
GN ORFNames=NEMVEDRAFT_v1g248474 {ECO:0000313|EMBL:EDO30268.1};
OS Nematostella vectensis (Starlet sea anemone).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Edwardsiidae; Nematostella.
OX NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO30268.1, ECO:0000313|Proteomes:UP000001593};
RN [1] {ECO:0000313|EMBL:EDO30268.1, ECO:0000313|Proteomes:UP000001593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX PubMed=17615350; DOI=10.1126/science.1139158;
RA Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA Technau U., Martindale M.Q., Rokhsar D.S.;
RT "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT genomic organization.";
RL Science 317:86-94(2007).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.26; Evidence={ECO:0000256|ARBA:ARBA00000885};
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DR EMBL; DS470092; EDO30268.1; -; Genomic_DNA.
DR RefSeq; XP_001622368.1; XM_001622318.1.
DR AlphaFoldDB; A7T196; -.
DR STRING; 45351.A7T196; -.
DR EnsemblMetazoa; EDO30268; EDO30268; NEMVEDRAFT_v1g248474.
DR eggNOG; KOG0939; Eukaryota.
DR HOGENOM; CLU_014403_0_0_1; -.
DR InParanoid; A7T196; -.
DR OMA; NLCIFGP; -.
DR PhylomeDB; A7T196; -.
DR Proteomes; UP000001593; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IBA:GO_Central.
DR GO; GO:0000209; P:protein polyubiquitination; IBA:GO_Central.
DR CDD; cd00078; HECTc; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR017868; Filamin/ABP280_repeat-like.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR PANTHER; PTHR11254:SF340; APOPTOSIS-RESISTANT E3 UBIQUITIN PROTEIN LIGASE 1; 1.
DR PANTHER; PTHR11254; HECT DOMAIN UBIQUITIN-PROTEIN LIGASE; 1.
DR Pfam; PF00632; HECT; 1.
DR SMART; SM00119; HECTc; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR PROSITE; PS50194; FILAMIN_REPEAT; 1.
DR PROSITE; PS50237; HECT; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001593};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT REPEAT 100..130
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT DOMAIN 420..761
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT ACT_SITE 728
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 761 AA; 86379 MW; DEC44B8617E99E1E CRC64;
MVPESKYRFH NRHCLAKKGL QIYLFGHYLQ PRFTKVKWEW QDPQVVGETL TFLLQIRHNY
TPFTVKRTDI DIEIVHDGTP IACSLDFGGP GWQEMNRVKV TFTVRKSGDY NIAVLAMGEH
ITGSPFAKVF LPGSVDPAKC TIIERSSILV LQQGVYSPLL VEARDVYGNL RSISNAEDLL
KYKVHIKKIG GSDSIDPELF VDSENRSNNS LHIKLEDEGI FQGTVSYDGT PVNNGELTII
SLNDSEWYAV EKNIDRHCYN VWYEAALLPY PLTGSNTPPS IGNGADVARK SRKVYCYISP
RNVSIKEFYM RIFPHKLHAF RVSPRTKFTL HPPNSNYEHP AFTISDGAQA PVSVVCRDRN
VLVATYSRLV LLNIGGSESF KKKREFFNEK LLSHQGMKGG EVRLKINRSN LLESSYVACK
NVDWLKMFNV TFEGEEGLDW GGVRREWFEL LCIALFGRDS ELFTRFKGDD PQAPVHPNPR
RPPHLNLKYY KFAGQVVSKC IYESAISNAR RQNVKAKFTR SFLAQLLGLR VNYKYLESDD
KDLYRSKVQL IEKNDPADLE LKFTEEEYNS SGQLEKVVEL LPGGRLIDVT EQNKCEYLNL
MARYKLVESV QKEVEAFIQG LNELVPDNLL GMFDENELEL LMCGTGHISV ADMKAHHHVL
AGGGQRFTKI MDWFWTIVSS LTQEELARLL QFVTGSSQLP PGGFAELSPQ LQISYIATSQ
ALPTAHTCFN QLCLPDFPSF NEMQRKLLLA VNEGCEGFGF S
//