ID A7T386_NEMVE Unreviewed; 439 AA.
AC A7T386;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 24-JAN-2024, entry version 68.
DE RecName: Full=Battenin {ECO:0000256|RuleBase:RU361113};
GN ORFNames=NEMVEDRAFT_v1g195662 {ECO:0000313|EMBL:EDO29577.1};
OS Nematostella vectensis (Starlet sea anemone).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Edwardsiidae; Nematostella.
OX NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO29577.1, ECO:0000313|Proteomes:UP000001593};
RN [1] {ECO:0000313|EMBL:EDO29577.1, ECO:0000313|Proteomes:UP000001593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX PubMed=17615350; DOI=10.1126/science.1139158;
RA Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA Technau U., Martindale M.Q., Rokhsar D.S.;
RT "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT genomic organization.";
RL Science 317:86-94(2007).
CC -!- SUBCELLULAR LOCATION: Lysosome membrane
CC {ECO:0000256|RuleBase:RU361113}; Multi-pass membrane protein
CC {ECO:0000256|RuleBase:RU361113}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the battenin family.
CC {ECO:0000256|ARBA:ARBA00007467, ECO:0000256|RuleBase:RU361113}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DS470436; EDO29577.1; -; Genomic_DNA.
DR RefSeq; XP_001621677.1; XM_001621627.1.
DR AlphaFoldDB; A7T386; -.
DR STRING; 45351.A7T386; -.
DR EnsemblMetazoa; EDO29577; EDO29577; NEMVEDRAFT_v1g195662.
DR eggNOG; KOG3880; Eukaryota.
DR HOGENOM; CLU_029663_1_2_1; -.
DR InParanoid; A7T386; -.
DR OMA; WLCNWQV; -.
DR PhylomeDB; A7T386; -.
DR Proteomes; UP000001593; Unassembled WGS sequence.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005773; C:vacuole; IBA:GO_Central.
DR GO; GO:0051453; P:regulation of intracellular pH; IBA:GO_Central.
DR CDD; cd06174; MFS; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR003492; Battenin_disease_Cln3.
DR InterPro; IPR018460; Battenin_disease_Cln3_subgr.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR10981; BATTENIN; 1.
DR PANTHER; PTHR10981:SF0; BATTENIN; 1.
DR Pfam; PF02487; CLN3; 1.
DR PIRSF; PIRSF015974; CLN3_BTN1; 1.
DR PRINTS; PR01315; BATTENIN.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE 3: Inferred from homology;
KW Lysosome {ECO:0000256|RuleBase:RU361113};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361113};
KW Reference proteome {ECO:0000313|Proteomes:UP000001593};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361113};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361113}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 40..60
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361113"
FT TRANSMEM 125..144
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361113"
FT TRANSMEM 151..173
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361113"
FT TRANSMEM 185..203
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361113"
FT TRANSMEM 215..233
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361113"
FT TRANSMEM 276..293
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361113"
FT TRANSMEM 366..389
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361113"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 439 AA; 48604 MW; 176E484812BF3012 CRC64;
MATASNDGAT NAPPNSVTTE TSQLTVGDDD DVCTRRRNLV GFWLLGLCNN FSYVVMLSAA
HDILKPTLEP KVNSSALHFE MDSKSNETDG LGCNPLSTGT ILLADILPTL LIKVTAPFYM
HKLSYNFRSI LCVLLAFASF FMVAYSHALG LSLLGVACAS ASSGFGEITL LSFSAHFDKD
VVSTWSSGTG AAGVFGALSY AGLISAGVSP RNTILIMNVV PVLFIISFWY ILVHPEYLQG
SYLINYATVH YKTEEHEQLE ISKMTFSQKL VVTKGLLKYM IPLFLVYFAE YFINQGLHEL
IFWKDIWITP SEQYRWYQVD YQLGVLISRS SVNILPIKNI CLLTGLQWVN LAVLAFESIY
HFLPSVWIMF AIVFFEGLLG GAVYVNAFYR VSKEVPPSER EFCMGITSVA DSTGIALAGA
TALPAHNALC KYWLHRVFR
//
