ID A7T3E6_NEMVE Unreviewed; 393 AA.
AC A7T3E6;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE RecName: Full=Lipase {ECO:0000256|PIRNR:PIRNR000862};
GN ORFNames=NEMVEDRAFT_v1g221778 {ECO:0000313|EMBL:EDO29518.1};
OS Nematostella vectensis (Starlet sea anemone).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Edwardsiidae; Nematostella.
OX NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO29518.1, ECO:0000313|Proteomes:UP000001593};
RN [1] {ECO:0000313|EMBL:EDO29518.1, ECO:0000313|Proteomes:UP000001593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX PubMed=17615350; DOI=10.1126/science.1139158;
RA Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA Technau U., Martindale M.Q., Rokhsar D.S.;
RT "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT genomic organization.";
RL Science 317:86-94(2007).
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase family.
CC {ECO:0000256|ARBA:ARBA00010701, ECO:0000256|PIRNR:PIRNR000862}.
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DR EMBL; DS470486; EDO29518.1; -; Genomic_DNA.
DR RefSeq; XP_001621618.1; XM_001621568.1.
DR AlphaFoldDB; A7T3E6; -.
DR STRING; 45351.A7T3E6; -.
DR ESTHER; nemve-a7t3e6; Acidic_Lipase.
DR EnsemblMetazoa; EDO29518; EDO29518; NEMVEDRAFT_v1g221778.
DR eggNOG; KOG2624; Eukaryota.
DR HOGENOM; CLU_010974_0_0_1; -.
DR InParanoid; A7T3E6; -.
DR OMA; DGEHVDC; -.
DR PhylomeDB; A7T3E6; -.
DR Proteomes; UP000001593; Unassembled WGS sequence.
DR GO; GO:0016788; F:hydrolase activity, acting on ester bonds; IEA:InterPro.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR006693; AB_hydrolase_lipase.
DR InterPro; IPR025483; Lipase_euk.
DR PANTHER; PTHR11005:SF163; LIPASE; 1.
DR PANTHER; PTHR11005; LYSOSOMAL ACID LIPASE-RELATED; 1.
DR Pfam; PF04083; Abhydro_lipase; 1.
DR PIRSF; PIRSF000862; Steryl_ester_lip; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|PIRNR:PIRNR000862};
KW Lipid degradation {ECO:0000256|PIRNR:PIRNR000862};
KW Lipid metabolism {ECO:0000256|PIRNR:PIRNR000862};
KW Reference proteome {ECO:0000313|Proteomes:UP000001593}.
FT DOMAIN 24..86
FT /note="Partial AB-hydrolase lipase"
FT /evidence="ECO:0000259|Pfam:PF04083"
FT ACT_SITE 161
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR000862-1"
FT ACT_SITE 334
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR000862-1"
FT ACT_SITE 363
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR000862-1"
SQ SEQUENCE 393 AA; 44714 MW; 0E74BDF639FFDA6A CRC64;
MSQADTWNCL LQKCLKPETN MIFTQLIQYN GYPVEDYDVT TEDGYILSVQ RIPYGREGKC
KGVKDKPVVF LQHGLLCSAT NWVTNLYNES FGFILADQCF DVWLGNVRGN TYGKRHVKLP
VDSDAFWDFS FDEMAKYDLP AMIDFVTKTT GQASLYYAGH SQGTMIGFIA FAHNPAVIQK
VKAFYALAPV STVSHMGGAL KYLAYLSPEI EFLFKVLGVR DFLPTDDLMR VLADLVCRPD
YIRVVCSDFL FLIAGMDRSQ LNETRLPIYI SHTPAGTSVK NVVHFAQIFR EKKFQMYDYG
SAEKNKHKYN QDTPPQYNVS AVKVPSALYW GGHDVLADPT DVKDLLAKLP HQMYNKYLPT
WDHLDFIWAL DAASLVYDDV IRHIKSKEME DAS
//
