ID A7T3U0_NEMVE Unreviewed; 334 AA.
AC A7T3U0;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0008006|Google:ProtNLM};
DE Flags: Fragment;
GN ORFNames=NEMVEDRAFT_v1g144785 {ECO:0000313|EMBL:EDO29372.1};
OS Nematostella vectensis (Starlet sea anemone).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Edwardsiidae; Nematostella.
OX NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO29372.1, ECO:0000313|Proteomes:UP000001593};
RN [1] {ECO:0000313|EMBL:EDO29372.1, ECO:0000313|Proteomes:UP000001593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX PubMed=17615350; DOI=10.1126/science.1139158;
RA Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA Technau U., Martindale M.Q., Rokhsar D.S.;
RT "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT genomic organization.";
RL Science 317:86-94(2007).
CC -!- SIMILARITY: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00009463}.
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DR EMBL; DS470644; EDO29372.1; -; Genomic_DNA.
DR RefSeq; XP_001621472.1; XM_001621422.1.
DR AlphaFoldDB; A7T3U0; -.
DR STRING; 45351.A7T3U0; -.
DR EnsemblMetazoa; EDO29372; EDO29372; NEMVEDRAFT_v1g144785.
DR KEGG; nve:5499934; -.
DR eggNOG; KOG1683; Eukaryota.
DR HOGENOM; CLU_009834_2_0_1; -.
DR InParanoid; A7T3U0; -.
DR OMA; CADSAGF; -.
DR PhylomeDB; A7T3U0; -.
DR Proteomes; UP000001593; Unassembled WGS sequence.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR022694; 3-OHacyl-CoA_DH.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR23309; 3-HYDROXYACYL-COA DEHYROGENASE; 1.
DR PANTHER; PTHR23309:SF9; PEROXISOMAL BIFUNCTIONAL ENZYME; 1.
DR Pfam; PF00725; 3HCDH; 1.
DR Pfam; PF02737; 3HCDH_N; 1.
DR PIRSF; PIRSF000105; HCDH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000001593}.
FT DOMAIN 10..187
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 190..281
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
FT SITE 144
FT /note="Important for catalytic activity"
FT /evidence="ECO:0000256|PIRSR:PIRSR000105-1"
FT NON_TER 334
FT /evidence="ECO:0000313|EMBL:EDO29372.1"
SQ SEQUENCE 334 AA; 36197 MW; F3415A032BD1BF39 CRC64;
MSKAFEVQQA AVIGAGTMGR GIVMSLANAG IQVLWLDNNP QMLDQAMAVV AQTNAHNVKL
ERISAEQSAA RLACVTPVGD YVALADADLV IEAVYENLEL KQQIFRTLDA TLKPGAILAS
NTSALDIDAI AAVTKRPEQV LGLHFFSPAH IMKLLEIVRG GQTAPAVLDA AVTLGQRIGK
VSVVAGNCDG FIGNRMLHTY VREARMLLLE GAYPHQVDAA LQGFGFAMGP FRMYDVVGID
LEWRARELAG KGQDDPTVQV DNRLCGLGRF GQKVRMGYYL YAEGSRQAEH DPEVDALVLQ
VSEQLGFVRR EIGPEEILER CLLALVNEGA KILE
//
