ID A7TAZ4_NEMVE Unreviewed; 235 AA.
AC A7TAZ4;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 24-JAN-2024, entry version 78.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EDO26823.1};
DE Flags: Fragment;
GN ORFNames=NEMVEDRAFT_v1g63947 {ECO:0000313|EMBL:EDO26823.1};
OS Nematostella vectensis (Starlet sea anemone).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Edwardsiidae; Nematostella.
OX NCBI_TaxID=45351 {ECO:0000313|EMBL:EDO26823.1, ECO:0000313|Proteomes:UP000001593};
RN [1] {ECO:0000313|EMBL:EDO26823.1, ECO:0000313|Proteomes:UP000001593}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CH2 X CH6 {ECO:0000313|Proteomes:UP000001593};
RX PubMed=17615350; DOI=10.1126/science.1139158;
RA Putnam N.H., Srivastava M., Hellsten U., Dirks B., Chapman J., Salamov A.,
RA Terry A., Shapiro H., Lindquist E., Kapitonov V.V., Jurka J.,
RA Genikhovich G., Grigoriev I.V., Lucas S.M., Steele R.E., Finnerty J.R.,
RA Technau U., Martindale M.Q., Rokhsar D.S.;
RT "Sea anemone genome reveals ancestral eumetazoan gene repertoire and
RT genomic organization.";
RL Science 317:86-94(2007).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC {ECO:0000256|ARBA:ARBA00004777, ECO:0000256|RuleBase:RU004254}.
CC -!- SIMILARITY: Belongs to the methylenetetrahydrofolate reductase family.
CC {ECO:0000256|ARBA:ARBA00006743}.
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DR EMBL; DS474616; EDO26823.1; -; Genomic_DNA.
DR RefSeq; XP_001618923.1; XM_001618873.1.
DR AlphaFoldDB; A7TAZ4; -.
DR STRING; 45351.A7TAZ4; -.
DR EnsemblMetazoa; EDO26823; EDO26823; NEMVEDRAFT_v1g63947.
DR eggNOG; KOG0564; Eukaryota.
DR HOGENOM; CLU_025841_0_2_1; -.
DR InParanoid; A7TAZ4; -.
DR OMA; EMHPQAR; -.
DR PhylomeDB; A7TAZ4; -.
DR UniPathway; UPA00193; -.
DR Proteomes; UP000001593; Unassembled WGS sequence.
DR GO; GO:0071949; F:FAD binding; IBA:GO_Central.
DR GO; GO:0004489; F:methylenetetrahydrofolate reductase (NAD(P)H) activity; IBA:GO_Central.
DR GO; GO:0009086; P:methionine biosynthetic process; IBA:GO_Central.
DR GO; GO:0035999; P:tetrahydrofolate interconversion; IBA:GO_Central.
DR CDD; cd00537; MTHFR; 1.
DR Gene3D; 3.20.20.220; -; 1.
DR InterPro; IPR029041; FAD-linked_oxidoreductase-like.
DR InterPro; IPR003171; Mehydrof_redctse-like.
DR PANTHER; PTHR45754; METHYLENETETRAHYDROFOLATE REDUCTASE; 1.
DR PANTHER; PTHR45754:SF3; METHYLENETETRAHYDROFOLATE REDUCTASE; 1.
DR Pfam; PF02219; MTHFR; 1.
DR SUPFAM; SSF51730; FAD-linked oxidoreductase; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000001593}.
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EDO26823.1"
FT NON_TER 235
FT /evidence="ECO:0000313|EMBL:EDO26823.1"
SQ SEQUENCE 235 AA; 26452 MW; 89F5D709106C705E CRC64;
GKSLFSFEIL PPLKGQNIQS IFDGIDPLME FNPPFIDVTY HREEYEFKEK GNGLLEKKIV
KKRPGTVGIC AAIQNKYNVD AIPHILCGGF TKEDTENLLI DLDFLGIDNV VALRGDAVKS
EIYFKPDKDG HSYASELVTQ IRNLNNGIYL DEDLQNSTKT DFCIGVAGYP EKHMEAPSID
SDIHFLKQKI KNGADYIVTQ MFFDNKRFFE FVTKCRVAGI TVPIIPGLKP IATKK
//