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Database: UniProt
Entry: A7TEB1_VANPO
LinkDB: A7TEB1_VANPO
Original site: A7TEB1_VANPO 
ID   A7TEB1_VANPO            Unreviewed;       358 AA.
AC   A7TEB1;
DT   02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT   02-OCT-2007, sequence version 1.
DT   08-MAY-2019, entry version 58.
DE   RecName: Full=Phospho-2-dehydro-3-deoxyheptonate aldolase {ECO:0000256|PIRNR:PIRNR001361};
DE            EC=2.5.1.54 {ECO:0000256|PIRNR:PIRNR001361};
GN   ORFNames=Kpol_1002p80 {ECO:0000313|EMBL:EDO19433.1};
OS   Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294)
OS   (Kluyveromyces polysporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae;
OC   Vanderwaltozyma.
OX   NCBI_TaxID=436907 {ECO:0000313|Proteomes:UP000000267};
RN   [1] {ECO:0000313|EMBL:EDO19433.1, ECO:0000313|Proteomes:UP000000267}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 22028 / DSM 70294 {ECO:0000313|Proteomes:UP000000267};
RX   PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA   Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M.,
RA   Wolfe K.H.;
RT   "Independent sorting-out of thousands of duplicated gene pairs in two
RT   yeast species descended from a whole-genome duplication.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-
CC         phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate;
CC         Xref=Rhea:RHEA:14717, ChEBI:CHEBI:15377, ChEBI:CHEBI:16897,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58394, ChEBI:CHEBI:58702;
CC         EC=2.5.1.54; Evidence={ECO:0000256|PIRNR:PIRNR001361};
CC   -!- SIMILARITY: Belongs to the class-I DAHP synthase family.
CC       {ECO:0000256|PIRNR:PIRNR001361}.
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DR   EMBL; DS480379; EDO19433.1; -; Genomic_DNA.
DR   RefSeq; XP_001647291.1; XM_001647241.1.
DR   STRING; 36033.XP_001647291.1; -.
DR   EnsemblFungi; EDO19433; EDO19433; Kpol_1002p80.
DR   GeneID; 5547784; -.
DR   KEGG; vpo:Kpol_1002p80; -.
DR   eggNOG; ENOG410IF83; Eukaryota.
DR   eggNOG; COG0722; LUCA.
DR   InParanoid; A7TEB1; -.
DR   KO; K01626; -.
DR   OMA; YDINTGL; -.
DR   OrthoDB; 1034517at2759; -.
DR   PhylomeDB; A7TEB1; -.
DR   Proteomes; UP000000267; Unassembled WGS sequence.
DR   GO; GO:0003849; F:3-deoxy-7-phosphoheptulonate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR006218; DAHP1/KDSA.
DR   InterPro; IPR006219; DHAP_synth_1.
DR   PANTHER; PTHR21225; PTHR21225; 1.
DR   Pfam; PF00793; DAHP_synth_1; 1.
DR   PIRSF; PIRSF001361; DAHP_synthase; 1.
DR   TIGRFAMs; TIGR00034; aroFGH; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Aromatic amino acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000267};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000267};
KW   Transferase {ECO:0000256|PIRNR:PIRNR001361}.
FT   DOMAIN       46    342       DAHP_synth_1. {ECO:0000259|Pfam:PF00793}.
FT   COILED       69     89       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   358 AA;  38879 MW;  8865CEBE69BBC51C CRC64;
     MAAPHADTED VRIIGYDPLV SPALLQVQVP ATDACLETVK KGREDAIKII TRQDDRLLVI
     VGPCSIHDLE AAQEYAQRLK KLSEELKDDL CVIMRAYLEK PRTTVGWKGL INDPDVNNSF
     NINKGLQSAR QLFVNLTNIG LPIGSEMLDT VSPQYLADLL SFGAIGARTT ESQLHRELAS
     GLSFPIGFKN GTDGTLEVAV DACKAASHSH HFMGVTKHGL AAITTTKGNE HCFVILRGGK
     KGTNYDAKSV AEAKAQLPEG SNGLMIDFSH GNSNKDFRNQ PKVNDVVCEQ IANGENMITG
     VMIESNINEG NQCVPPEGKA GLKYGVSITD ACISWETTDE VLRKLAAAVR QRREVNKN
//
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