ID A7TEM7_VANPO Unreviewed; 955 AA.
AC A7TEM7;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE RecName: Full=Na(+)/H(+) antiporter {ECO:0008006|Google:ProtNLM};
GN ORFNames=Kpol_1036p80 {ECO:0000313|EMBL:EDO19334.1};
OS Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS
OS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Vanderwaltozyma.
OX NCBI_TaxID=436907 {ECO:0000313|Proteomes:UP000000267};
RN [1] {ECO:0000313|EMBL:EDO19334.1, ECO:0000313|Proteomes:UP000000267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 /
RC NRRL Y-8283 / UCD 57-17 {ECO:0000313|Proteomes:UP000000267};
RX PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.;
RT "Independent sorting-out of thousands of duplicated gene pairs in two yeast
RT species descended from a whole-genome duplication.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the fungal Na(+)/H(+) exchanger family.
CC {ECO:0000256|ARBA:ARBA00005248}.
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DR EMBL; DS480380; EDO19334.1; -; Genomic_DNA.
DR RefSeq; XP_001647192.1; XM_001647142.1.
DR AlphaFoldDB; A7TEM7; -.
DR STRING; 436907.A7TEM7; -.
DR GeneID; 5547674; -.
DR KEGG; vpo:Kpol_1036p80; -.
DR eggNOG; KOG4505; Eukaryota.
DR HOGENOM; CLU_008635_0_1_1; -.
DR InParanoid; A7TEM7; -.
DR OMA; WPITCFF; -.
DR OrthoDB; 1607026at2759; -.
DR PhylomeDB; A7TEM7; -.
DR Proteomes; UP000000267; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0015385; F:sodium:proton antiporter activity; IEA:InterPro.
DR GO; GO:0120029; P:proton export across plasma membrane; IEA:InterPro.
DR GO; GO:0042391; P:regulation of membrane potential; IEA:InterPro.
DR GO; GO:0036376; P:sodium ion export across plasma membrane; IEA:InterPro.
DR InterPro; IPR013928; Cation/H_antiporter_C.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR004712; Na+/H+_antiporter_fungi.
DR PANTHER; PTHR31382; NA(+)/H(+) ANTIPORTER; 1.
DR PANTHER; PTHR31382:SF4; NA(+)_H(+) ANTIPORTER; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR Pfam; PF08619; Nha1_C; 1.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Ion transport {ECO:0000256|ARBA:ARBA00023201};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000267};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 14..33
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 103..126
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 204..225
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 245..262
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 296..315
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 327..349
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 361..381
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 414..438
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 20..436
FT /note="Cation/H+ exchanger"
FT /evidence="ECO:0000259|Pfam:PF00999"
FT DOMAIN 464..954
FT /note="Alkali metal cation/H+ antiporter Nha1 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08619"
FT REGION 840..875
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 911..955
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 846..862
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 955 AA; 106468 MW; DF0F94080E3D5CCF CRC64;
MAVWHIIEAT KPHIAYAVVG VFSAIFSLVS LFIKQRLYIG ESTLAGIYGL IVGPHCLKWF
SPTTWGNTDS ITLEITRIVL CLQIFAVAVE LPRKYMLKHW VSVAMLLLPV MTAGWLIIGL
FVWIIIPGLN FPSGLLISAC ITATDPILAQ SVISGKFAQR VPGHLRNLLA AESGCNDGMA
FPFIFLSLNL ILYPGNGREI VKNWFCITLL YECIFGCVFG VFIGYTGRRA IKFAKEKNLI
DRESFLSFYI FLSFCCAGFG SIIGVDDLLV SFAAGTAFAW DGWFSEVTEE TKISTVIELL
LNYSYFIYFG AIVPWEQFNN SEIGTDVWRL IILAIIVIFL RRIPAVLALK HFIPDIKSWR
EALFVGHFGP IGVGAVFAAI LSRAELESSV SHEETPLAEL PPKGTPHWQL MACVWPITCF
FIVTSILVHG SSVAVITLSR HLNTITLSKS FSTHTTFGGT KPSWMARLPT LDKSGRSFSL
QRVDTMGSAS NQATPGDMSR TSTIETSGVP VRRAGGMTRR KKYKHNKARR KLKKRREQLL
GIYGVNEFND DELNDLGRER LQLEKEAQAG TFALGGAKPI ASKQSIDLSA ITTESHEFDE
TPSSDKSDEV SHKLDATSAS LSPNIQEKLY NDEFGDNLEN IQSRPMVDMD DEIYEGASHI
SSEQERRDKL FEMESIPKVA YAEGDNIIVE NRQGEILDEI NLRRGPNDEE ASVFSGNDSL
VRVLSNDTVQ SFRALKNVLS PISSRDTSHN SHKPKYHAYK VGSTIIIENE EGEVLRRYRI
RTHSEVPNDK KKEIENQKEV AGSSGVFSRT LSKLGLRSRA SSSAQPPSPR DIENAQKMVR
HLTPAPKRVK ISESPDEISD NDEHSLSETD DEEIEEEEII STTSIDSSIQ DYVPQELHNY
DRTLHDVIDN ESMDGANIND DYSSGEESET SVERRRRLAA LGQLSGPRPD DDEET
//
