ID A7TG42_VANPO Unreviewed; 1982 AA.
AC A7TG42;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE RecName: Full=RNA helicase {ECO:0008006|Google:ProtNLM};
GN ORFNames=Kpol_1028p75 {ECO:0000313|EMBL:EDO18799.1};
OS Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS
OS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Vanderwaltozyma.
OX NCBI_TaxID=436907 {ECO:0000313|Proteomes:UP000000267};
RN [1] {ECO:0000313|EMBL:EDO18799.1, ECO:0000313|Proteomes:UP000000267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 /
RC NRRL Y-8283 / UCD 57-17 {ECO:0000313|Proteomes:UP000000267};
RX PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.;
RT "Independent sorting-out of thousands of duplicated gene pairs in two yeast
RT species descended from a whole-genome duplication.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
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DR EMBL; DS480385; EDO18799.1; -; Genomic_DNA.
DR RefSeq; XP_001646657.1; XM_001646607.1.
DR STRING; 436907.A7TG42; -.
DR GeneID; 5547115; -.
DR KEGG; vpo:Kpol_1028p75; -.
DR eggNOG; KOG0952; Eukaryota.
DR HOGENOM; CLU_000335_2_1_1; -.
DR InParanoid; A7TG42; -.
DR OMA; MCSATEF; -.
DR OrthoDB; 57056at2759; -.
DR PhylomeDB; A7TG42; -.
DR Proteomes; UP000000267; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0034641; P:cellular nitrogen compound metabolic process; IEA:UniProt.
DR GO; GO:0010467; P:gene expression; IEA:UniProt.
DR GO; GO:0044238; P:primary metabolic process; IEA:UniProt.
DR CDD; cd18020; DEXHc_ASCC3_1; 1.
DR CDD; cd18022; DEXHc_ASCC3_2; 1.
DR CDD; cd18795; SF2_C_Ski2; 2.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR Gene3D; 1.10.3380.10; Sec63 N-terminal domain-like domain; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004179; Sec63-dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR47961; DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED; 1.
DR PANTHER; PTHR47961:SF13; SEC63 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00270; DEAD; 2.
DR Pfam; PF00271; Helicase_C; 2.
DR Pfam; PF02889; Sec63; 2.
DR PIRSF; PIRSF039073; BRR2; 1.
DR SMART; SM00382; AAA; 2.
DR SMART; SM00487; DEXDc; 2.
DR SMART; SM00490; HELICc; 2.
DR SMART; SM00973; Sec63; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR SUPFAM; SSF158702; Sec63 N-terminal domain-like; 2.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 2.
DR PROSITE; PS51194; HELICASE_CTER; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000000267}.
FT DOMAIN 301..489
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 525..735
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 1153..1328
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 1366..1570
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 1982 AA; 225601 MW; 1B61642D39B1311A CRC64;
MTTEYSIHSA GSYMQAMQAM MHSVDQYDMK IGVSELPEIN GESDEQVGKT TLIKLAQDRN
EWDDIFDDFK DLNYEKFVKM VDDVKKCNGV NGGDSSGSTV FKRLVRLAST CSSSLSTGTL
LKSVLEITFA NEKGQLAEQL LDLVGAENVE LISFVLENRQ LITAHSLEDV IQMTRDIIDS
SEFDYLTEQE MKDQVIQNAY DAKNQKLDPA RRVIKYPHVY RKYEDGNTSS LAFSGQKFSL
PIGTTRQSYQ SHEELIIPAA DPDTNKKVFH TRLMSIDSLD HYCRAVFKYK TLNKIQSLVF
PVAYNTNENM LICAPTGAGK TDIALLTILN IIKQFSQVNE HNELDIQYDD FKVIYVAPLK
ALAAEIVEKF SEKLAIFDIQ VRELTGDMQL TRAEIQTTQV IVTTPEKWDV VTRKANGDND
LVSKVKLLII DEVHLLHEDR GSVIETLVAR TLRQVESSQS MIRIVGLSAT LPNFMDVADF
LGVNRQVGMF YFDQSFRPKP LEQQLLGCRG NAGSRQSREN IDRVSYDKLI EMIQRGYQVM
VFVHARKETV NSARTYIRIA EQNSEITEFA PDADMKNKYS KELAKNRDKD LRELFQFGFG
IHHAGMARTD RNLTEKMFKD GAIKVLCCTA TLAWGVNLPA DCVIIKGTQV YDSKKGGFID
LGISDVIQIF GRAGRPGFGS EHGTGILCTS NDRLDHYVSL LTQQHPIESK LGSKLVDNLN
AEISLGTVTN VEEAVQWLGY TYLYVRMRKN PFTYAIDWEE LASDPQLYDR RRKMVVTAAR
RLHSLQMIVF DEISMHFIPK DLGRVASDFY LLNESVEIFN QMCNPRATEA DVLSMISMSS
EFDGIKFREE EAVELTRLSE SAVECQIGGA LDTAQGKANV LLQAYISQSK IFDSALNSDS
NYVAQNATRI CRALFLIGIN RRWGNFAKVM LDVCKSIEKR LWAFDHPLCQ FDLPDPIIRQ
IRDRNPSMDH LMDLEPEEIG ELVHNRGIGN KLFNLISKFP SISISAEIFP ITTNVMRIHV
NLIPDFKWDF RVHGDVQFFW VLVEESDKSQ VLHFEKYILR KAQLNTVHEM DFMIPLSDPL
PPQVVVKVVS DTWIGCESTF PISFQHLIRP YNETLQTKLL RLKPLPTSAL NNPLVQSIYP
FKYFNPMQTM TFHTLYNTND NVFVGSPTGS GKTVVAELAI WHAFRDFPGK KIVYIAPMKA
LVRERVDDWR KRITPVTGDR VVELTGDSLP DPKDVRDATI VITTPEKFDG ISRNWQTRKF
VQNISLVIMD EIHLLASDRG PILEMIVSRM NYIASQTSNP IRLLGMSTAV SNAYDMASWL
GVKSNGLFNF PSSVRPVPLN MYIDGFPDNL AYCPLMKTMN KPAFMAIKQH SPVKPALIFV
SSRRQTRLTA LDLIHLCGME DNPRRFLKID DDGELQYYIS QITDDTLKLS IQFGIGLHHA
GLVEKDRDIS HQLFQKGKLQ ILVATSTLAW GVNLPAHLVV IKGTQFYDKK VLGYVDMDLT
DILQMMGRAG RPAYDTTGTA IVYTRENKKM FYKHFLNVGF PVESSLHKVL EDHLGAEINS
GTVCNKQDAI DFLRWTFFFR RAHHNPTYYG ILEDTSAAGV HKHISELIDK SIEELVSSRC
VEVYGEDIEA TPFLSIASYY YISHKTIRTL LAQIKDNARF IDVLKWLSLA EEYNELPVRG
GETIMNEEMS AQLRYPAETI FTGEYELPIF DTHVKAFLLL QAHLSRVNLP IADYIQDTVS
VLDQSLRILQ AFVDVASELG YFNTVLTIIK AMQCIKQGYW YEDDPASALP GCELKRFNDI
EFLESGHPLD AKSQSSKVNL NGIARMGFKK LQNLAIQNDL SYADLKNDDE VSEEVLAERI
QRKFISVCQR LPALDDVKVE KQEDNTKVVI TSKHHSKQNN REFEVYCDKF PKMQKESWFC
IGYKNNELYM IKRCHPQQDK DKTVNITCEF IVTEELRGKD MDFLLINDAL SLEYHINHQL
LK
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