ID A7TGB0_VANPO Unreviewed; 2095 AA.
AC A7TGB0;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 27-MAR-2024, entry version 98.
DE RecName: Full=Rho-GAP domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=Kpol_1055p35 {ECO:0000313|EMBL:EDO18680.1};
OS Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS
OS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Vanderwaltozyma.
OX NCBI_TaxID=436907 {ECO:0000313|Proteomes:UP000000267};
RN [1] {ECO:0000313|EMBL:EDO18680.1, ECO:0000313|Proteomes:UP000000267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 /
RC NRRL Y-8283 / UCD 57-17 {ECO:0000313|Proteomes:UP000000267};
RX PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.;
RT "Independent sorting-out of thousands of duplicated gene pairs in two yeast
RT species descended from a whole-genome duplication.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
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DR EMBL; DS480386; EDO18680.1; -; Genomic_DNA.
DR RefSeq; XP_001646538.1; XM_001646488.1.
DR STRING; 436907.A7TGB0; -.
DR GeneID; 5546985; -.
DR KEGG; vpo:Kpol_1055p35; -.
DR eggNOG; KOG1450; Eukaryota.
DR HOGENOM; CLU_002085_0_0_1; -.
DR InParanoid; A7TGB0; -.
DR OMA; TLEDDRW; -.
DR OrthoDB; 1359393at2759; -.
DR PhylomeDB; A7TGB0; -.
DR Proteomes; UP000000267; Unassembled WGS sequence.
DR GO; GO:0005933; C:cellular bud; IEA:UniProt.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProt.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd06224; REM; 1.
DR CDD; cd00159; RhoGAP; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR23176:SF96; GTPASE-ACTIVATING PROTEIN BEM2_IPL2; 1.
DR PANTHER; PTHR23176; RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 2.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000000267}.
FT DOMAIN 499..781
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT DOMAIN 1842..1876
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1895..2093
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 205..229
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 285..306
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1683..1706
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1725..1758
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..53
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 64..148
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1683..1701
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2095 AA; 238730 MW; 2ABDB8E37DBB04EA CRC64;
MRGFRWSTRH RKSTYNSGNN NNNEYNDNND NNTTTDTTHL SSVTSSSSSS HDQHLHTHST
KRKSSFISGR FSKSTENITE GSNTSVITAN NPTINTANTT GNHNINANSI NNNNNSSSKN
NSSSNSIGSN TNPDSNMNNN SGSASSNNGS SISIVNNIPT TANVRPTSTA GSTEVFLDNE
NYDTTIFKVG WLNKSVGFIH PLRRSPSNHS LSQPQQPSLS ANNNDTDSLK TQIPSEHSYQ
DTVIPDYRVH KAVLKGSVLS LYKNGLHSNI KYFDPLLKKS SNNNETHHNI SNNNEHMHQH
NTQNQNQNQQ IINHHDTHND KKQNIDSTSN YIDTKNIQIK FTSDSFPHPN LKLDKNGKII
SGTVESLSHA VLFQDASSRS TINLILILPL LENFNKFLSC FVQYTKLYIN SKKHHQIIVE
RISLLIKTIA ELLSSFLLID SNYQLLIQLI KLTSSEKLIS LIDLKISKIR NLIFFTNLIP
DPSASNYLLN SNNFLQNVDI DKFTETFHRI NLKFDKIWSP RLDYSLLYDS NFTHLNLFDN
KKNLKLKNLN PLVFNNNENF HLLGRLLTIH VMNTHSTPSQ RAKLITKWIK IGCKFEQIGD
MVSWLAIATI ICSLPILRLQ NTWNFIDEDL LKILFKDWIP TIIQLDRRQF SSKSTQSVFI
LAPPNLNDPI IRNNVISYFG DLMIHADELP SDSKLKYLEK KINRTKNAFH KWEQKLHEND
NLAIPSMANM NQLELDNYEF QDLIKKDNVS NSIFHYWRFH LSQPNMNVEN LMKLSLQIEP
SRLDAKSYSS NVSQRSPLLS GSYLPIIFND LLQNYSLFTK NSLIGASGML SHSHSSMFVN
ESNKKNPPPR SSARISKTIS ISEPLSVVNS NLSNIIDLKS SNNDASKQVT GFNKVDMPTI
KEISMKQSNK QKMMRSIRDI LNIDMDLFHI SNDLIFKSTD DNEVTSRPAS IVIESAKRFS
QLSISNNTDG STINRDNLDS QSISTKSLEN MDFFKNISKI SETISETTVI NTVLKSGSLD
KIFDLLVLTI NIFSNSIDTD DLKNYFNSRK KKSNFNPNLN LVQNYNFENT RLPKSPSSTN
LSLSREKDSD IGLLDYAFVR LSMDNTNFTE TFFNTYKTFT TATSVIENLA KRFIKAKNCA
ISISYMLLPI SETNSSNSTD KNQNMNWHLQ VPDWDIKITN EEDINYIFVI MIHIGVMEAT
LHFVKNHYSD LTDDLEIKPT FLDFFKIMEQ EVTVEWPNII KLIKNDPNSK HETLQSIESH
FLRINELFYN IKESFQNQLY KPVGVSPSKR EALNLLDKFS NISFDELSTL FNTDTENIDN
MLSDFTSLDY KDYPSILSWI NRLDCFVTKN FNLANNGELF ITYEQLNLFS TQSLTALFNC
SPQSETIKLL NSGSLQLVEL SISNIFTWIT SITYDDGSLL FDDLPTSVKV LINLHKSLTA
FFTIIISDVN CSFDIRLNRC CVVLQILNYV RWKNSSLDLF DNQTPEDPNS SISPHIPSFI
ETAISNAMVT PESRSFELAW RTAYSLMNSN HSEKPLRSIY KIMDDIDDIH IKSFIEIDMT
VLNKPKNLSP CPGWFISRLL EISQFVPNMS MTNSKLINFD KRRFVHNFIS NIFDLIPHYN
ESEDNTRDEF GSILYFTFDK KSTTFRQKVK NVSILESKQM NFNDSGLFNE LLINEVDKLK
REQRKRETLL SQERESKKTS TLQETVAKNK RNSVIIPNIY QSTPPRSVHL SNSTSISSRD
KRGSVPVMSS RNSMSATSHT GVSKKLGEFF RSPFFSSSSS NTSLNSILVH DVQGNGSICP
AALPSIDISI LQDNKALHTI RTFEIKSIVP TVNHRMNPAY LYSFKIVMQN GSDYMIQASS
LEDLNEWVSM IKASKRYSFY SRKFKGRTHN KIFGVPLEDV CERESTTIPT IVTKLLEEIE
LRGLDEVGLY RIPGSAGSIN ALKNAFDEEG AISNSFTLED DRWFEINAIA GCFKMYLREL
PDSLFTNEKV GDFAQLAINY KSGRISENEF TSRMNTLLSE LPTCYYHTMK QIVTHLNRVH
QHVSHNRMDA SNLAIVFSMS FIDQEDLASS MGANLGAIQT ILQHFIKNPE TYFIN
//