ID A7TGF6_VANPO Unreviewed; 1020 AA.
AC A7TGF6;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 24-JAN-2024, entry version 74.
DE RecName: Full=A-factor-processing enzyme {ECO:0008006|Google:ProtNLM};
GN ORFNames=Kpol_1055p83 {ECO:0000313|EMBL:EDO18726.1};
OS Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS
OS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Vanderwaltozyma.
OX NCBI_TaxID=436907 {ECO:0000313|Proteomes:UP000000267};
RN [1] {ECO:0000313|EMBL:EDO18726.1, ECO:0000313|Proteomes:UP000000267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 /
RC NRRL Y-8283 / UCD 57-17 {ECO:0000313|Proteomes:UP000000267};
RX PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.;
RT "Independent sorting-out of thousands of duplicated gene pairs in two yeast
RT species descended from a whole-genome duplication.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
CC -!- SIMILARITY: Belongs to the peptidase M16 family.
CC {ECO:0000256|ARBA:ARBA00007261, ECO:0000256|RuleBase:RU004447}.
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DR EMBL; DS480386; EDO18726.1; -; Genomic_DNA.
DR RefSeq; XP_001646584.1; XM_001646534.1.
DR AlphaFoldDB; A7TGF6; -.
DR STRING; 436907.A7TGF6; -.
DR MEROPS; M16.008; -.
DR GeneID; 5547036; -.
DR KEGG; vpo:Kpol_1055p83; -.
DR eggNOG; KOG0959; Eukaryota.
DR HOGENOM; CLU_004639_1_1_1; -.
DR InParanoid; A7TGF6; -.
DR OMA; WIFDEMK; -.
DR OrthoDB; 129328at2759; -.
DR PhylomeDB; A7TGF6; -.
DR Proteomes; UP000000267; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR InterPro; IPR011249; Metalloenz_LuxS/M16.
DR InterPro; IPR011765; Pept_M16_N.
DR InterPro; IPR001431; Pept_M16_Zn_BS.
DR InterPro; IPR007863; Peptidase_M16_C.
DR InterPro; IPR032632; Peptidase_M16_M.
DR PANTHER; PTHR43690:SF18; INSULIN-DEGRADING ENZYME-RELATED; 1.
DR PANTHER; PTHR43690; NARDILYSIN; 1.
DR Pfam; PF00675; Peptidase_M16; 1.
DR Pfam; PF05193; Peptidase_M16_C; 2.
DR Pfam; PF16187; Peptidase_M16_M; 1.
DR SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
DR PROSITE; PS00143; INSULINASE; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000000267};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 86..221
FT /note="Peptidase M16 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00675"
FT DOMAIN 249..420
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
FT DOMAIN 433..713
FT /note="Peptidase M16 middle/third"
FT /evidence="ECO:0000259|Pfam:PF16187"
FT DOMAIN 717..899
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
SQ SEQUENCE 1020 AA; 117587 MW; AE07431BD110EE0A CRC64;
MSFALINQSL LSNIGISVKS NVPTILSRSI PLYLRNFTKI NYYKRKMSTT SDVTKKPYKI
HDLNFIKPDL DDRSYRFIEL PNKFKALLIH DASTDKSAAS LDVNIGAFQD PKNLQGLAHF
CEHLLFMGSK KFPNENEYSS YLNKHGGSSN AYTGAQNTNY FFEINHEHLH GALDRFSGFF
TCPLFNPNST SKEINAVDSE NKKNLQNDVW RMYQLDKSLS NEKHPYHKFS TGNLKTLDEM
PKKEGLDIRN ELLKFYSDSY SANLMKLCVL GREDLDTMSD WVYNLFEAVP NNNRPLPEYN
EPILLEENLK KIIHVKPVKD LKKLEITFLA QDMDLFWESK PQHILSHLIG HEGSGSILSH
LKTLSWANEL SAGGHTVSKD NAFFSIDIDL TENGFQHYKE IVHIVFQYIE MLKISLPQER
IFLELQDIAN ASFKFKQKVN PSSTVSNLSK ALEKEYIPVE NILSTGLFRK YDPEIMKNYV
NSLSPDNSRI TLAGKAVETD SKETWYGTDY RVEDYPKDLY DTIKSPGLNP NLSIPRPNEF
IATNFDVEKF DVNEPLVEPL LLKDSPVSKL WYKKDDRFWQ PRGFIYITMK LPHTQASVIN
NLLTSLYVQL VNDSLKDLQY DAACANLHLS FSKTNQGLDI TISGFNDKLI VLLQRFIYGV
SVYQPSKLRF KIFKEKTIQN LKNCLYEVPY SQISTLYSSL INERTWSVKQ KLSIIEKITY
EQFLAFLPTI YEECYFDGLV HGNFRNEEAV EIDSLVQSLI TTDIVNLHVK NTRLRSYVIP
NGETYRFEID LEDAENVNSC VQHVVQLGGY SEELSAMSGL FAQILNEPCF DTLRTKEQLG
YVVFSSSLNN HGTANIRILV QSEHSTPYLE WRIDEFYKSF GETLRNMSDD ELEKHKDALC
KSLMQKYKNM KEENSRYTAA IYLGDYNFTH RQKKANLVAQ ISKDQLIKFF EDHFISANAA
KLVIHLKSKV KSSDKDINED KLDVKKYPTG KLITDVDEFK SKLYAAPIRQ PLKKFDVYKP
//