GenomeNet

Database: UniProt
Entry: A7TGF6_VANPO
LinkDB: A7TGF6_VANPO
Original site: A7TGF6_VANPO 
ID   A7TGF6_VANPO            Unreviewed;      1020 AA.
AC   A7TGF6;
DT   02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT   02-OCT-2007, sequence version 1.
DT   24-JAN-2024, entry version 74.
DE   RecName: Full=A-factor-processing enzyme {ECO:0008006|Google:ProtNLM};
GN   ORFNames=Kpol_1055p83 {ECO:0000313|EMBL:EDO18726.1};
OS   Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS
OS   2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Vanderwaltozyma.
OX   NCBI_TaxID=436907 {ECO:0000313|Proteomes:UP000000267};
RN   [1] {ECO:0000313|EMBL:EDO18726.1, ECO:0000313|Proteomes:UP000000267}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 /
RC   NRRL Y-8283 / UCD 57-17 {ECO:0000313|Proteomes:UP000000267};
RX   PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA   Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.;
RT   "Independent sorting-out of thousands of duplicated gene pairs in two yeast
RT   species descended from a whole-genome duplication.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
CC   -!- SIMILARITY: Belongs to the peptidase M16 family.
CC       {ECO:0000256|ARBA:ARBA00007261, ECO:0000256|RuleBase:RU004447}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; DS480386; EDO18726.1; -; Genomic_DNA.
DR   RefSeq; XP_001646584.1; XM_001646534.1.
DR   AlphaFoldDB; A7TGF6; -.
DR   STRING; 436907.A7TGF6; -.
DR   MEROPS; M16.008; -.
DR   GeneID; 5547036; -.
DR   KEGG; vpo:Kpol_1055p83; -.
DR   eggNOG; KOG0959; Eukaryota.
DR   HOGENOM; CLU_004639_1_1_1; -.
DR   InParanoid; A7TGF6; -.
DR   OMA; WIFDEMK; -.
DR   OrthoDB; 129328at2759; -.
DR   PhylomeDB; A7TGF6; -.
DR   Proteomes; UP000000267; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR   InterPro; IPR011249; Metalloenz_LuxS/M16.
DR   InterPro; IPR011765; Pept_M16_N.
DR   InterPro; IPR001431; Pept_M16_Zn_BS.
DR   InterPro; IPR007863; Peptidase_M16_C.
DR   InterPro; IPR032632; Peptidase_M16_M.
DR   PANTHER; PTHR43690:SF18; INSULIN-DEGRADING ENZYME-RELATED; 1.
DR   PANTHER; PTHR43690; NARDILYSIN; 1.
DR   Pfam; PF00675; Peptidase_M16; 1.
DR   Pfam; PF05193; Peptidase_M16_C; 2.
DR   Pfam; PF16187; Peptidase_M16_M; 1.
DR   SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
DR   PROSITE; PS00143; INSULINASE; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW   Protease {ECO:0000256|ARBA:ARBA00022670};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000267};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   DOMAIN          86..221
FT                   /note="Peptidase M16 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00675"
FT   DOMAIN          249..420
FT                   /note="Peptidase M16 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05193"
FT   DOMAIN          433..713
FT                   /note="Peptidase M16 middle/third"
FT                   /evidence="ECO:0000259|Pfam:PF16187"
FT   DOMAIN          717..899
FT                   /note="Peptidase M16 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05193"
SQ   SEQUENCE   1020 AA;  117587 MW;  AE07431BD110EE0A CRC64;
     MSFALINQSL LSNIGISVKS NVPTILSRSI PLYLRNFTKI NYYKRKMSTT SDVTKKPYKI
     HDLNFIKPDL DDRSYRFIEL PNKFKALLIH DASTDKSAAS LDVNIGAFQD PKNLQGLAHF
     CEHLLFMGSK KFPNENEYSS YLNKHGGSSN AYTGAQNTNY FFEINHEHLH GALDRFSGFF
     TCPLFNPNST SKEINAVDSE NKKNLQNDVW RMYQLDKSLS NEKHPYHKFS TGNLKTLDEM
     PKKEGLDIRN ELLKFYSDSY SANLMKLCVL GREDLDTMSD WVYNLFEAVP NNNRPLPEYN
     EPILLEENLK KIIHVKPVKD LKKLEITFLA QDMDLFWESK PQHILSHLIG HEGSGSILSH
     LKTLSWANEL SAGGHTVSKD NAFFSIDIDL TENGFQHYKE IVHIVFQYIE MLKISLPQER
     IFLELQDIAN ASFKFKQKVN PSSTVSNLSK ALEKEYIPVE NILSTGLFRK YDPEIMKNYV
     NSLSPDNSRI TLAGKAVETD SKETWYGTDY RVEDYPKDLY DTIKSPGLNP NLSIPRPNEF
     IATNFDVEKF DVNEPLVEPL LLKDSPVSKL WYKKDDRFWQ PRGFIYITMK LPHTQASVIN
     NLLTSLYVQL VNDSLKDLQY DAACANLHLS FSKTNQGLDI TISGFNDKLI VLLQRFIYGV
     SVYQPSKLRF KIFKEKTIQN LKNCLYEVPY SQISTLYSSL INERTWSVKQ KLSIIEKITY
     EQFLAFLPTI YEECYFDGLV HGNFRNEEAV EIDSLVQSLI TTDIVNLHVK NTRLRSYVIP
     NGETYRFEID LEDAENVNSC VQHVVQLGGY SEELSAMSGL FAQILNEPCF DTLRTKEQLG
     YVVFSSSLNN HGTANIRILV QSEHSTPYLE WRIDEFYKSF GETLRNMSDD ELEKHKDALC
     KSLMQKYKNM KEENSRYTAA IYLGDYNFTH RQKKANLVAQ ISKDQLIKFF EDHFISANAA
     KLVIHLKSKV KSSDKDINED KLDVKKYPTG KLITDVDEFK SKLYAAPIRQ PLKKFDVYKP
//
DBGET integrated database retrieval system