GenomeNet

Database: UniProt
Entry: A7TJM9
LinkDB: A7TJM9
Original site: A7TJM9 
ID   DRS1_VANPO              Reviewed;         752 AA.
AC   A7TJM9;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   16-OCT-2019, entry version 58.
DE   RecName: Full=ATP-dependent RNA helicase DRS1;
DE            EC=3.6.4.13;
GN   Name=DRS1; ORFNames=Kpol_534p53;
OS   Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294)
OS   (Kluyveromyces polysporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae;
OC   Vanderwaltozyma.
OX   NCBI_TaxID=436907;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 22028 / DSM 70294;
RX   PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA   Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M.,
RA   Wolfe K.H.;
RT   "Independent sorting-out of thousands of duplicated gene pairs in two
RT   yeast species descended from a whole-genome duplication.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
CC   -!- FUNCTION: ATP-binding RNA helicase involved in ribosome assembly.
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC   -!- SUBUNIT: Associates with pre-ribosomal particles. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- DOMAIN: The Q motif is unique to and characteristic of the DEAD
CC       box family of RNA helicases and controls ATP binding and
CC       hydrolysis.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX27/DRS1
CC       subfamily. {ECO:0000305}.
DR   EMBL; DS480402; EDO17572.1; -; Genomic_DNA.
DR   RefSeq; XP_001645430.1; XM_001645380.1.
DR   SMR; A7TJM9; -.
DR   STRING; 36033.XP_001645430.1; -.
DR   PRIDE; A7TJM9; -.
DR   EnsemblFungi; EDO17572; EDO17572; Kpol_534p53.
DR   GeneID; 5545797; -.
DR   KEGG; vpo:Kpol_534p53; -.
DR   eggNOG; KOG0338; Eukaryota.
DR   eggNOG; COG0513; LUCA.
DR   InParanoid; A7TJM9; -.
DR   KO; K13181; -.
DR   OMA; HEPERSW; -.
DR   OrthoDB; 268859at2759; -.
DR   Proteomes; UP000000267; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IEA:EnsemblFungi.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000027; P:ribosomal large subunit assembly; IEA:EnsemblFungi.
DR   GO; GO:0006364; P:rRNA processing; IEA:EnsemblFungi.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR   InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS51195; Q_MOTIF; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Coiled coil; Complete proteome; Helicase; Hydrolase;
KW   Nucleotide-binding; Nucleus; Reference proteome; Ribosome biogenesis;
KW   RNA-binding.
FT   CHAIN         1    752       ATP-dependent RNA helicase DRS1.
FT                                /FTId=PRO_0000310215.
FT   DOMAIN      262    437       Helicase ATP-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00541}.
FT   DOMAIN      448    611       Helicase C-terminal.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00542}.
FT   NP_BIND     275    282       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00541}.
FT   COILED      631    698       {ECO:0000255}.
FT   MOTIF       231    259       Q motif.
FT   MOTIF       385    388       DEAD box.
FT   COMPBIAS    136    224       Glu-rich.
SQ   SEQUENCE   752 AA;  84998 MW;  2FACC25F9AFD3EFA CRC64;
     MAVTSDRKNN RKKAITKFND LDFVPTISDS EEDVPDLDDS DDELLTSENK SVKTPAKSKK
     GKKNDPVKIN GNGDEVAEDL NPDFRFNIDG GELSTNFQGW DFVGDQKEND DDMKKDVDLD
     GIIRRKGGLL NMAHIEVAEE EEEEEEEEEE EEEEEEEELA MDGFGMGATK KNEQEEAGDE
     DDDDNEEEEE EEVDDDKEDD DEEREEDTAE EMASFYAPES ESSEATSTVH STFNSLTLSR
     PVLKGLSDLG YTKPSPIQSA TIPIGLSGKD IIAGAVTGSG KTAAFMIPII ERLLYKPAKV
     ASTRVIVLTP TRELAIQIAD VGKKIGKYVS GLTFGLAVGG LNLRQQEQEL KTRPDIVIAT
     PGRFIDHVRN SSSFNVDSVE VLVMDEADRM LEEGFQEELN EILTLLPSKR QTLLFSATMN
     SRIKSLISLS LRKPVRIMIN PPKQAAARLT QEFVRIRKRD HLKPALLFYL IRKLDGTGQK
     RIVVFVARKE MAHKLRIILG LLGMKVGELH GSLTQEQRLQ SVNNFKSLEV PVLICTDLAS
     RGLDIPKIEV VINFDMPKSY EIYLHRVGRT ARAGREGRSV TFVGESSQDR SIVRSAIKSV
     EESSSKNKAV SRNVEWTQIE ETNKLVESFG ETIDDILVEE KQEKEILRAE MQLRKGENMI
     KHKKEIQSRP KRTWFQSEAE KKNAKILDTL QKNKKTVNSK KRKRLEALED NDNSRSYKKT
     QKDRVVDQER SMKKQKIANG KKSKNKKKFN KR
//
DBGET integrated database retrieval system