ID   A7TKT2_VANPO            Unreviewed;       816 AA.
AC   A7TKT2;
DT   02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT   02-OCT-2007, sequence version 1.
DT   27-MAR-2024, entry version 54.
DE   RecName: Full=SPX domain-containing protein {ECO:0000259|PROSITE:PS51382};
GN   ORFNames=Kpol_1025p6 {ECO:0000313|EMBL:EDO17087.1};
OS   Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS
OS   2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Vanderwaltozyma.
OX   NCBI_TaxID=436907 {ECO:0000313|Proteomes:UP000000267};
RN   [1] {ECO:0000313|EMBL:EDO17087.1, ECO:0000313|Proteomes:UP000000267}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 /
RC   NRRL Y-8283 / UCD 57-17 {ECO:0000313|Proteomes:UP000000267};
RX   PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA   Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.;
RT   "Independent sorting-out of thousands of duplicated gene pairs in two yeast
RT   species descended from a whole-genome duplication.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Vacuole membrane
CC       {ECO:0000256|ARBA:ARBA00004128}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004128}.
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DR   EMBL; DS480410; EDO17087.1; -; Genomic_DNA.
DR   RefSeq; XP_001644945.1; XM_001644895.1.
DR   AlphaFoldDB; A7TKT2; -.
DR   STRING; 436907.A7TKT2; -.
DR   GeneID; 5545277; -.
DR   KEGG; vpo:Kpol_1025p6; -.
DR   eggNOG; ENOG502QSRA; Eukaryota.
DR   HOGENOM; CLU_016933_0_0_1; -.
DR   InParanoid; A7TKT2; -.
DR   OMA; IRYWNEF; -.
DR   OrthoDB; 2616090at2759; -.
DR   PhylomeDB; A7TKT2; -.
DR   Proteomes; UP000000267; Unassembled WGS sequence.
DR   GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0033254; C:vacuolar transporter chaperone complex; IEA:UniProt.
DR   GO; GO:0006799; P:polyphosphate biosynthetic process; IEA:UniProt.
DR   CDD; cd14474; SPX_YDR089W; 1.
DR   InterPro; IPR004331; SPX_dom.
DR   PANTHER; PTHR46140; VACUOLAR TRANSPORTER CHAPERONE 1-RELATED; 1.
DR   PANTHER; PTHR46140:SF1; VACUOLAR TRANSPORTER CHAPERONE 4; 1.
DR   Pfam; PF03105; SPX; 1.
DR   PROSITE; PS51382; SPX; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000267};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        720..744
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        756..784
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        790..812
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          1..146
FT                   /note="SPX"
FT                   /evidence="ECO:0000259|PROSITE:PS51382"
SQ   SEQUENCE   816 AA;  93500 MW;  B05C17A974E513C2 CRC64;
     MKFAQSILDK SVPEWKFNNI DYEKLKKLIK EATTASDNDT KNLNKLASSF KEQLENVNLF
     TSMKVKELST RLVSIESSIL HFKEMKSVSK NVQKNQLRLI MSHLDDCNSE WQKLSRFVIL
     QRIALKKLFK KFTKHYHGGQ EEAKDYIEKI KDSPEYKDGY EGISFVNIDL EPFLLEVSLI
     AAVIHELNTN LKQNSTNNDR ENIIDDSKTV NSTLEFDTIS LGNSSTVQSF LLSIENIEEF
     KFMLLKSGYH LVDDEVSFSR EVLENSDITS NRTTTSARSI TDLRTIIKDQ HMKHQAEASQ
     KSCTSTTALC TQSRLVYYLI DSNPSSPLFL ENESMNLYPN ILLTEKNNFD SKHNVLLCHV
     GGIRDHFTTN KLSYSYLQDI ISKETQEEVN AETNKRNSNP VEKLAVQWIS SHNLKILDTS
     ISFNRSRFVK YSDTETYYIT LDDEFTFNGK SISHAYVKIN KSNSMNSKIS VSKTNKKKRS
     TEFEKLCELI IENKCQCYPL SEVNTEWKIF YQLKDSHDLQ ADLYSLALQD KYEIEENIRL
     TTEEFFKIGT QLVLEMCSTD FQAEQQNVDS INPLTVKENG DNVENDVGRV RYWNEFDDGE
     DFADNGFYVN NSLESQSFLS ENAYPKDNGF IKFSKPFINS VYDFCQKFRS TIGLQVGDEY
     PPLLSFSNGR TKYTSRGSIP SGISSSISND HFDELLEYER QNIEDSDAIY EYKHDQVVTF
     MYLTILSVSS VTSGISLGII LALFKGGSSD SNLEVASILT IIIISSLLVS LILNCTSLML
     LFSRFTLAPL WHYIISFLLF LLVTCTVCYG IIEIFL
//