ID   A7TMV1_VANPO            Unreviewed;      1379 AA.
AC   A7TMV1;
DT   02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT   02-OCT-2007, sequence version 1.
DT   27-MAR-2024, entry version 76.
DE   RecName: Full=REM-1 domain-containing protein {ECO:0008006|Google:ProtNLM};
DE   Flags: Fragment;
GN   ORFNames=Kpol_1030p33 {ECO:0000313|EMBL:EDO16423.1};
OS   Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS
OS   2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Vanderwaltozyma.
OX   NCBI_TaxID=436907 {ECO:0000313|Proteomes:UP000000267};
RN   [1] {ECO:0000313|EMBL:EDO16423.1, ECO:0000313|Proteomes:UP000000267}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 /
RC   NRRL Y-8283 / UCD 57-17 {ECO:0000313|Proteomes:UP000000267};
RX   PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA   Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.;
RT   "Independent sorting-out of thousands of duplicated gene pairs in two yeast
RT   species descended from a whole-genome duplication.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
CC   -!- SIMILARITY: Belongs to the RICTOR family.
CC       {ECO:0000256|ARBA:ARBA00008878}.
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DR   EMBL; DS480425; EDO16423.1; -; Genomic_DNA.
DR   RefSeq; XP_001644281.1; XM_001644231.1.
DR   STRING; 436907.A7TMV1; -.
DR   GeneID; 5544556; -.
DR   KEGG; vpo:Kpol_1030p33; -.
DR   eggNOG; KOG3694; Eukaryota.
DR   HOGENOM; CLU_001013_1_1_1; -.
DR   InParanoid; A7TMV1; -.
DR   OMA; EIRIHAT; -.
DR   OrthoDB; 90320at2759; -.
DR   PhylomeDB; A7TMV1; -.
DR   Proteomes; UP000000267; Unassembled WGS sequence.
DR   GO; GO:0031932; C:TORC2 complex; IEA:InterPro.
DR   GO; GO:0031929; P:TOR signaling; IEA:InterPro.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR028268; Pianissimo_fam.
DR   InterPro; IPR028267; Pianissimo_N.
DR   InterPro; IPR029453; Rictor_IV.
DR   InterPro; IPR029451; RICTOR_M.
DR   InterPro; IPR029452; RICTOR_V.
DR   PANTHER; PTHR13298; CYTOSOLIC REGULATOR PIANISSIMO; 1.
DR   PANTHER; PTHR13298:SF11; RAPAMYCIN-INSENSITIVE COMPANION OF MTOR; 1.
DR   Pfam; PF14663; RasGEF_N_2; 1.
DR   Pfam; PF14666; RICTOR_M; 1.
DR   Pfam; PF14664; RICTOR_N; 1.
DR   Pfam; PF14668; RICTOR_V; 1.
DR   SMART; SM01303; RasGEF_N_2; 1.
DR   SMART; SM01307; RICTOR_M; 1.
DR   SMART; SM01308; RICTOR_N; 1.
DR   SMART; SM01310; RICTOR_V; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000267}.
FT   DOMAIN          284..630
FT                   /note="Rapamycin-insensitive companion of mTOR N-terminal"
FT                   /evidence="ECO:0000259|SMART:SM01308"
FT   DOMAIN          695..919
FT                   /note="Rapamycin-insensitive companion of mTOR middle"
FT                   /evidence="ECO:0000259|SMART:SM01307"
FT   DOMAIN          1121..1193
FT                   /note="Rapamycin-insensitive companion of mTOR"
FT                   /evidence="ECO:0000259|SMART:SM01310"
FT   REGION          54..75
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          77..111
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          135..162
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:EDO16423.1"
SQ   SEQUENCE   1379 AA;  158753 MW;  6FDF0BB050792ED0 CRC64;
     FQQMYNTETS PKATALRSRS NTIYTDISNT NSTVSSGSNG TKKNRKNLVL STSFLSTKRP
     DNGPISPNSP LQGKWKKNSL NKNLVKIKND INQLNQTLYQ TKKKKKDAET LLKSTSLNIY
     TGTYSTSHLE KHSMRIKANT QIRELDNSIK KLEKQISESK LQYEVTVKSI EPHNALDGNF
     LNSANTSRED LISHSYEDEG YDTEFERPDT SDISLRESLQ RKDAISYDSL IPDEDLNIGD
     DEFTYSRKYS TDEYIAANRE TAIWLISDYM QSLQTSNTSV DFIIRKANDF VTILRDHPEI
     REDLLLTPFL PTLQQLLLND DKFVVSAAFR ICRYLVDGPQ FIETLKKLEI DAFIVISLGK
     ENIFQIEREQ ALKLARTFGE HKKLSKSMLQ ALISCIEKPE DSLKNMALET LLELCFIDPE
     LVTECNGIRV LENLLQDYSS FSLAKIILDT ILQLISTQET RKYFLKDFSI SVLATTFSDT
     NTKSASNVER LQNSAILISK ALKNADGCRL FSINNFKPLK DLLSFFEIPL CASYLVDIFL
     DVLRIKPLQY KFKSKSTQII GYPASSYQKD CIPINQNVAL LILILNKSNF VNQLLKVINN
     NKIDEYKDTL VNKARYLLIE YLNLAANLVD AELTLFNDVI PKGDVSIFRE TYQFGKITYI
     LNKNRNTLGL EKINYTDNIQ KISQDIKANT LIRQVDDLKF RRMVFDSKVL QVKDFSLWNW
     NVIQELLEGP LTNARQLEEL GKTKFIRKLL VFYRPLRQRF SNVDKKSRLA QKYIQVGCKF
     FKMLTLTSEG MKILMDDNKI IPQLASLLFR AMEGKTDGNI FNEISLKTKT VVGYFKFIGV
     LTKSLNGTKV LDKWNFFTVI YKMFQIENKL SFTYLMYTLP EIDLRFSPHC RTIMGKALVI
     GDEQIRLNST QYMSNNLKEI TEMINNQGQN NNTKEALTPK LLLEYNSLQQ YMLEMLTRQL
     FDLSPKVVAV ADQSLYEHVV RDENTSTEVG TWLRTSLNQM VFISSPILFE LMSSKYGFQI
     LNEIQYIEHE RESWLLNKNL EYVSIVEEFI DNFQTFGNNN VYNFEVSNRL PLHFYESLAK
     TDDGINLLTT SGDLVKFMNV IKKYRTELKN GDKVNESLED IIELKCCIWC CGYIGSTPLG
     IGLIDNYSIV EDFITLTYEA TVTSVRSTAF YALGLIAKTK EGCEILDEMG WICSYNVFGE
     PVGIATPKRI DSYLSYKESQ WKIHDTFEES MISFDISSGN LVEEEKIVPI KINLDDMLTE
     KYKNENPLIE NKAIKSGKRI SSSKKLAEIE SDTGGYDKII DKVVESVCEL SNHILMNKAI
     KEIGELKEEY EIVFENYKMF YKIFELMTKF RFKPNIRKFL FNLFINKKSL KNAIAQSSQ
//