ID A7TN87_VANPO Unreviewed; 3034 AA.
AC A7TN87;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE RecName: Full=Ras-GAP domain-containing protein {ECO:0000259|PROSITE:PS50018};
GN ORFNames=Kpol_1053p43 {ECO:0000313|EMBL:EDO16305.1};
OS Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS
OS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Vanderwaltozyma.
OX NCBI_TaxID=436907 {ECO:0000313|Proteomes:UP000000267};
RN [1] {ECO:0000313|EMBL:EDO16305.1, ECO:0000313|Proteomes:UP000000267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 /
RC NRRL Y-8283 / UCD 57-17 {ECO:0000313|Proteomes:UP000000267};
RX PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.;
RT "Independent sorting-out of thousands of duplicated gene pairs in two yeast
RT species descended from a whole-genome duplication.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
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DR EMBL; DS480428; EDO16305.1; -; Genomic_DNA.
DR RefSeq; XP_001644163.1; XM_001644113.1.
DR STRING; 436907.A7TN87; -.
DR GeneID; 5544445; -.
DR KEGG; vpo:Kpol_1053p43; -.
DR eggNOG; KOG1826; Eukaryota.
DR HOGENOM; CLU_000439_0_0_1; -.
DR InParanoid; A7TN87; -.
DR OMA; CPANDID; -.
DR OrthoDB; 1356198at2759; -.
DR PhylomeDB; A7TN87; -.
DR Proteomes; UP000000267; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProt.
DR CDD; cd05392; RasGAP_Neurofibromin_like; 1.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194:SF150; INHIBITORY REGULATOR PROTEIN IRA1-RELATED; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF00616; RasGAP; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000000267}.
FT DOMAIN 1653..1842
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 426..530
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 841..887
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 957..980
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 426..469
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 484..530
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3034 AA; 346307 MW; 491AC580CD6A194B CRC64;
MEELPNDQFM VNTLLKHLYF DRLFPMLPIE SALSTYREVE SDLLFLSCRS VILNVAISQD
LGPVVQQTLD LIDLILRNEN INSPNITEDA IHSIFVMIRL LSDVMEYYWD SNEGDMLEND
SRNEQIDASN KDQNGRRKSQ IPIGKQKSLF TGTIVGYSTH RPNFHTSRPA SLNPELAKRL
VYTCSRVKFS RLTCRVLSNI SQNFSHYTVS SIDNISPNYR YFKNNPSLIP LIERIDLTVD
YIQRFVAASN PTEFFQFIKS KALSPSLKKD TESWNEIVCH YDLMGCIFLS KRSFPKFFEV
IKSIVVNLKK SIFSCLFLYY SSKALMYWFM ARPKEYEEII LSFKELSRIE SDSKEKDAKL
SETLLKAKHL SNLSTSLFDE IYSVFAVPNM LTSSTSSSNS STTSNLNSSS NNLSIHINTG
VASLHTSSSI SPSVTHPPRE QTTTPGSVKS NLSNVSSTQS AQLISNPVSP AVGSIGRKYH
PPNTSELLQP SPNPSSHAST IDDMYSYSTC TKGDESTDSS ELSTQRSIDQ ASTRPMNDIF
HLINVLDLYT TFDESESLIH TSVLRFLSVL LLLDPDVFSE INTIPFKYIR DAAPESSRAL
IDKEKEREKA LSMKHLTHGL RKLTTLTPQK VSKPVKFLTS LMRIYNGSHS SSDLTLLDSI
RALLSLFTVS SAVALRSNKL PAAMFASRLI DSFGINLEIG KDWNAPLIPN IVQCLNKHKR
MTTRFQLEYF AASLQLETHT FLEHLNLEAA AKEMDTDKLV LYTEGLRVFF HLPNFQILRR
KTAIQTAPFF KGLFSNVSDI ILKDFPYFNE YSVSEIVASI MEGTLIDKFG AKGVSIRSSP
SSLSSMISPS PATKPSQATS PVGMDSGWTQ HPIIPTSSNS SDLSDISSST VSNVSEMSFS
NLISPRARRV SGNSGVLKRS SLLASQGDLE NKGSSDSHVL VSNGFTSATP IQPAVPRTIR
SPIRPPPLPK RNKDDSSVKV TKQTLNTSSD PNMYSISDIE NARRVMLNIF SIFKRTANFF
LLPDDNTLSY DMAGEDFKLI IKPIFIAIID SSKTLESTAQ SFMNVLIKFM SELDATVSSP
VLNAYYLFCS YSVTLFSSAL FDLNLTNNKR EILLDIVSKL LQVKSILGKI AEETKRIDFI
KDSEEKTFNG LVGSVGRGLF VSLHTNKGNV QKLLTKAYLE YYQTLSFHKN NIGNLEDKWR
GNMEFVLAMS KDNYVSSGSV AFQRRLRTNI LKYIGHPDEM LLDSIRVIFR KWMQISNTRC
LSPEDLADFR SYAGIIASLS GVMLTIAEDG PVRYPFLLEV KMEITKEINH FISKQCSWLN
NDDLLTRENS RDILSTELHP LSFKLLFYNL KLKFEEVRTV DLSQDEQSSY FILLEQIIII
IRTILRRDDD QQVLFLFSLD IVNFIDQLVE LVEKVDQKSS KYYKIVIHLS KMFRAMKHSE
KNLGLAGHYL LKNKWLKLVT KWFKLSIAKE FDCENLSKPH REMDLKRRDL DLLYLDTSIE
SSKAIAYLTL ELPLEIPPAL SEEEMRRSSG LIFRNYFGIL LKGIEKTTDM KKFPTSLKHK
VTILTENLIA SLTNLSNSNV EPALQYTLPM GFSENKDIRI SFLKVFINVV KNYPNRKSNT
EKIKIEATNE LLKFLIKYPH LITQATNVCS SAEIDEYTVG LVSAFDTKNA AHILITQLVK
DEIQDSIRHM DILRRNSVAT RALSLYSRSK GNEYLVKIIG PVLEQMVEDK AYFEVEKLQL
DDPNASEQLD LFEKYMKILI DAIIGSIDCF PVELFVVCQV IYSEVRKKFP EYSLVAVGSF
VFLRFICPAL VSPETENIIG VTPLKEKRSL IQMAKVIQNM ANGSDNLLKW PSLATKLDFL
KKCNDDIFEF LAELSRTDRV IKIPLNSSTT LPSNVTMLWN LNFFHTFLYM HELQIRKGNL
DEMKSFTNFN LLRDSIMLVD RVLGIWGQPV WECRNEIPLF VKENVDRYPQ LYEFMSRYAF
KRVLSTAEDA TYVHESMSSD GFQILTLTFS HFISLGFDVD SIVYRTLQVY ARIWSNNHYL
VLDCTEFHSE ECDIPKLTTL FLSLLPDEAF QHCIGYYFLN VTESFMDSWA ALLTMDNPYI
SHKVPIFFVN TISDQEMINT IGLSPQTTAV LEDVRISLHE INLFEEEKQI FKPVAMRLGN
KYFQVLHEEP KKYYFEGFDT GFDIKFNYVY SISQVANVLV SYTKGMPNEF MVTFTDGKKL
IFTSPKYLEI VKMFSYALAK IQDDIGISNM LSPITKTKNK TTIGNEKETL SHIILVVLAG
LFHNDDVVKN IAYNLLATTQ DAFNLNFGIK FRTTPEMYVP DDCTTFLRQL SKAIAESAPE
LTPHIFKLLI EALENGIIPQ DYIPQTVCCM SYWIPNLYKY VYISDEEEGP EELSYMIRVL
IRLTISEPHF TSVYLQHIWY IIVLDGRLCN IIVEEVVNHA LERDSENRDW TKVLPLLTGL
STVDIACNII HRLMRIIDSF LPSLKMEVST QSWSELTILV KIAIPLFFES PMLAQMYLPE
VLFIVSLLID QGPKHIRSCF HQLLMNICHS LAINDSLSEI NRKNLDEVCC IFSRQKLKFM
FGFSQDKGSV LRNFSISSFA SKFNTLEHFT TNIFFAMENA DISESAHWKT RYKKYLMDSI
FNRDSFLSAR AMMILGIIGK SNTSEMLCKN LLKETMKVMA EPHVDDEAIF LLISHVFTYS
KIVEGLDPSS NLMKQLFWFA TCLTESPHPL IFEGGMLLLS NCLKRMYMLK FEISFDRSKT
LSSTLIEARK FAEPVLLELE VARDVTWNID SFSQVLLSII IRGLAIPFVK PAAIDCLEQF
FKNAYYEYRM HATSTDYLSY LFLLFLISTP DQFYNMLHVV EFEGEMTTLD DLNRIPTVLA
DWLASDACFS NVALYQGAVL FSSSVSDELT KLRFAIIMRY LLKTNPICVF RFYTVTRNEL
RRISTLEHNL NSVTVAFELI TLLVTYKEFE ELQDFNKSSL DNFKEIGLLS VTKIRTFPFQ
HIGDVLMGIQ EQPKLIYERK RLLTMVLGRM ACHD
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