ID A7TPA2_VANPO Unreviewed; 643 AA.
AC A7TPA2;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE RecName: Full=mRNA 3'-end-processing protein RNA14 {ECO:0000256|ARBA:ARBA00026188, ECO:0000256|RuleBase:RU369035};
GN ORFNames=Kpol_1019p9 {ECO:0000313|EMBL:EDO15889.1};
OS Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS
OS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Vanderwaltozyma.
OX NCBI_TaxID=436907 {ECO:0000313|Proteomes:UP000000267};
RN [1] {ECO:0000313|EMBL:EDO15889.1, ECO:0000313|Proteomes:UP000000267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 /
RC NRRL Y-8283 / UCD 57-17 {ECO:0000313|Proteomes:UP000000267};
RX PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.;
RT "Independent sorting-out of thousands of duplicated gene pairs in two yeast
RT species descended from a whole-genome duplication.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
CC -!- FUNCTION: Component of the cleavage factor IA (CFIA) complex, which is
CC involved in the endonucleolytic cleavage during polyadenylation-
CC dependent pre-mRNA 3'-end formation. {ECO:0000256|RuleBase:RU369035}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU369035}.
CC Cytoplasm {ECO:0000256|RuleBase:RU369035}. Note=Nucleus and/or
CC cytoplasm. {ECO:0000256|RuleBase:RU369035}.
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DR EMBL; DS480440; EDO15889.1; -; Genomic_DNA.
DR RefSeq; XP_001643747.1; XM_001643697.1.
DR AlphaFoldDB; A7TPA2; -.
DR STRING; 436907.A7TPA2; -.
DR GeneID; 5543995; -.
DR KEGG; vpo:Kpol_1019p9; -.
DR eggNOG; KOG1914; Eukaryota.
DR HOGENOM; CLU_007630_0_1_1; -.
DR InParanoid; A7TPA2; -.
DR OMA; PKRQYFK; -.
DR OrthoDB; 23291at2759; -.
DR PhylomeDB; A7TPA2; -.
DR Proteomes; UP000000267; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006378; P:mRNA polyadenylation; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.40.1040; -; 1.
DR Gene3D; 6.10.250.1660; -; 1.
DR InterPro; IPR003107; HAT.
DR InterPro; IPR045243; Rna14-like.
DR InterPro; IPR008847; Suf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR19980:SF0; CLEAVAGE STIMULATION FACTOR SUBUNIT 3; 1.
DR PANTHER; PTHR19980; RNA CLEAVAGE STIMULATION FACTOR; 1.
DR Pfam; PF05843; Suf; 2.
DR SMART; SM00386; HAT; 7.
DR SUPFAM; SSF48452; TPR-like; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|RuleBase:RU369035};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664,
KW ECO:0000256|RuleBase:RU369035}; Nucleus {ECO:0000256|RuleBase:RU369035};
KW Reference proteome {ECO:0000313|Proteomes:UP000000267}.
FT DOMAIN 391..566
FT /note="Suppressor of forked"
FT /evidence="ECO:0000259|Pfam:PF05843"
FT DOMAIN 577..637
FT /note="Suppressor of forked"
FT /evidence="ECO:0000259|Pfam:PF05843"
FT REGION 567..597
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 567..581
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 582..596
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 643 AA; 76661 MW; 9986AE8645BEBA53 CRC64;
MSDSNNIDKD EIVLLKQRIQ DHPVDILGYL ELIKVLEKSD NFAESREVYD QLHKRFPFYS
PLWTIQLKNE LQRDEFETVE KLLAQCLSGD LENNDLALWS TYLDYVRRKN NIITGGQEAR
AIVIKAFDLV LEKCATFEPR SSQFWNDYLG FLETWKPVNK WEEQQRIDLI RSLYKKMLCV
PFDNLEKMWS RYTQWEQDTN NLTARKFIGE ISSEYMKARS CYQEWLNLTS NLRRVSPNSL
NSANKKNIPQ YDNESIAFDQ LKIWRNWIKW EKENKLLLSD DLLRKRILYI YRQGIQNLLF
VPEIWYQYSM YDNEILQRQQ ILSIAVLANP NSATLTFKLA ECFESNNNNE KVQETFENCT
KCLINDYNKI LEECANDNDH PTVYRVRHEL TFVYCIYMNT MKRLSGLSAA RVVFGKCRKW
KGILTHIIYI ENAYLEFQNQ FDYKTAFKVL ELGLKFFQND GKYINKYLDF LILLNRDSQI
KTLFESSVEK VNDLTQLKSI FKKMIAYESK FGNLGNVYAL EERYFKKFPN EKLIETFTER
YTIQNENVLK KLELTYLQQE NRFNNEHELD TSQFNPMKRS LENDQNDNHE KKMKSNPSIP
PEIFDLLTVL PKRQYFKTAL LDPHKFINYL NDQVELPSSS DKV
//
