ID A7TPK8_VANPO Unreviewed; 430 AA.
AC A7TPK8;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=Nucleoside transporter FUN26 {ECO:0008006|Google:ProtNLM};
GN ORFNames=Kpol_1040p13 {ECO:0000313|EMBL:EDO15800.1};
OS Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS
OS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Vanderwaltozyma.
OX NCBI_TaxID=436907 {ECO:0000313|Proteomes:UP000000267};
RN [1] {ECO:0000313|EMBL:EDO15800.1, ECO:0000313|Proteomes:UP000000267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 /
RC NRRL Y-8283 / UCD 57-17 {ECO:0000313|Proteomes:UP000000267};
RX PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.;
RT "Independent sorting-out of thousands of duplicated gene pairs in two yeast
RT species descended from a whole-genome duplication.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
CC {ECO:0000256|ARBA:ARBA00007965}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DS480444; EDO15800.1; -; Genomic_DNA.
DR RefSeq; XP_001643658.1; XM_001643608.1.
DR AlphaFoldDB; A7TPK8; -.
DR STRING; 436907.A7TPK8; -.
DR GeneID; 5543897; -.
DR KEGG; vpo:Kpol_1040p13; -.
DR eggNOG; KOG1479; Eukaryota.
DR HOGENOM; CLU_021611_3_0_1; -.
DR InParanoid; A7TPK8; -.
DR OMA; GSPWTTK; -.
DR OrthoDB; 517168at2759; -.
DR PhylomeDB; A7TPK8; -.
DR Proteomes; UP000000267; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005337; F:nucleoside transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR002259; Eqnu_transpt.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR10332; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER; 1.
DR PANTHER; PTHR10332:SF90; NUCLEOSIDE TRANSPORTER FUN26; 1.
DR Pfam; PF01733; Nucleoside_tran; 2.
DR PIRSF; PIRSF016379; ENT; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000267};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 36..57
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 69..94
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 106..129
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 135..163
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 170..189
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 201..222
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 262..286
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 330..348
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 360..382
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 402..423
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 430 AA; 47984 MW; 9A63F9508CF1BDDF CRC64;
MDEDTLVSST RNSTANDEIP DLEGTTFFFK VCEPNYFTFL CIGMGLLWPW NCILSASEYF
QNDIFHGTSI WANIFTSSMM SVSTVTSLLF NLWLSKRQMA YSQRVVRGLI LEILVFSLLV
AVTFVHSLFP QSLNFIWIMF LVVISAIGTA LTQNGILAIA NVYGSEYSQA VVLGQAIAGV
LPSIVLFLIT FSDKPDNKGS LIGIILYFLS TSLVSLICIY LFRSNNSDRV LKDTPTSFTE
SESLSDNKIF VPTELLYSKL KYLVLSIFVT FSVTMVFAVF ASTIVARGIP LSDKQYIPLI
FTVWNVGDLC GRFIAELPFF RNDSFTAYKT FVYSLSRIAL LPLFFLFLRI PKRSPILQDI
SYIMLQFIFG LTSGQVISMS FMKIPGALDS DVEREAAGGF SNVFVSVGLA AGSLLSYVFV
FIISKMKQTV
//
