ID A7TQ26_VANPO Unreviewed; 323 AA.
AC A7TQ26;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 13-SEP-2023, entry version 73.
DE RecName: Full=Methylenetetrahydrofolate dehydrogenase [NAD(+)] {ECO:0008006|Google:ProtNLM};
GN ORFNames=Kpol_489p12 {ECO:0000313|EMBL:EDO15631.1};
OS Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS
OS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Vanderwaltozyma.
OX NCBI_TaxID=436907 {ECO:0000313|Proteomes:UP000000267};
RN [1] {ECO:0000313|EMBL:EDO15631.1, ECO:0000313|Proteomes:UP000000267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 /
RC NRRL Y-8283 / UCD 57-17 {ECO:0000313|Proteomes:UP000000267};
RX PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.;
RT "Independent sorting-out of thousands of duplicated gene pairs in two yeast
RT species descended from a whole-genome duplication.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
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DR EMBL; DS480451; EDO15631.1; -; Genomic_DNA.
DR RefSeq; XP_001643489.1; XM_001643439.1.
DR AlphaFoldDB; A7TQ26; -.
DR STRING; 436907.A7TQ26; -.
DR GeneID; 5543733; -.
DR KEGG; vpo:Kpol_489p12; -.
DR eggNOG; KOG0089; Eukaryota.
DR HOGENOM; CLU_031413_0_0_1; -.
DR InParanoid; A7TQ26; -.
DR OMA; CKVITAE; -.
DR OrthoDB; 2232005at2759; -.
DR PhylomeDB; A7TQ26; -.
DR Proteomes; UP000000267; Unassembled WGS sequence.
DR GO; GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IEA:InterPro.
DR GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
DR CDD; cd01079; NAD_bind_m-THF_DH; 1.
DR Gene3D; 3.40.50.10860; Leucine Dehydrogenase, chain A, domain 1; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR046346; Aminoacid_DH-like_N_sf.
DR InterPro; IPR035812; m-THF_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR000672; THF_DH/CycHdrlase.
DR InterPro; IPR020630; THF_DH/CycHdrlase_cat_dom.
DR InterPro; IPR020631; THF_DH/CycHdrlase_NAD-bd_dom.
DR PANTHER; PTHR48099; C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED; 1.
DR PANTHER; PTHR48099:SF3; METHYLENETETRAHYDROFOLATE DEHYDROGENASE [NAD(+)]; 1.
DR Pfam; PF00763; THF_DHG_CYH; 1.
DR Pfam; PF02882; THF_DHG_CYH_C; 1.
DR PRINTS; PR00085; THFDHDRGNASE.
DR SUPFAM; SSF53223; Aminoacid dehydrogenase-like, N-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW One-carbon metabolism {ECO:0000256|ARBA:ARBA00022563};
KW Reference proteome {ECO:0000313|Proteomes:UP000000267}.
FT DOMAIN 14..124
FT /note="Tetrahydrofolate dehydrogenase/cyclohydrolase
FT catalytic"
FT /evidence="ECO:0000259|Pfam:PF00763"
FT DOMAIN 147..212
FT /note="Tetrahydrofolate dehydrogenase/cyclohydrolase
FT NAD(P)-binding"
FT /evidence="ECO:0000259|Pfam:PF02882"
SQ SEQUENCE 323 AA; 36378 MW; 21B9E572B3047380 CRC64;
MSSSALKPGS TILASTVANN FGEEIIKKVD SLKSSLPNGP LLVGFLANND PAAEMYATWT
KKSCESMGFR YELRRVEDRD FLEEAIIEAN RDDSVNGIMV YYPVFGNAQD QYLQQVVSRE
KDVEGLNHVY YQNLYHNIRF LDSNNELKSI LPCTPLAVVK IMEYLKIYNT LLPEGNRLYG
RKCVVINRSE IVGRPLAALL ANDGATVYSV DVNNIQKFTR GEGLKFTKHH VEDLGPYSED
LLKKCCQDSD VIITGVPSES YKIPTEYIKD GTSCINFSSF RNFDDSVKTK ASLYVPMTGK
VTIVMLLRNM LRLIENNQKL HGK
//
