ID A7TR65_VANPO Unreviewed; 767 AA.
AC A7TR65;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=Amino acid transporter transmembrane domain-containing protein {ECO:0000259|Pfam:PF01490};
GN ORFNames=Kpol_1029p6 {ECO:0000313|EMBL:EDO15233.1};
OS Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS
OS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Vanderwaltozyma.
OX NCBI_TaxID=436907 {ECO:0000313|Proteomes:UP000000267};
RN [1] {ECO:0000313|EMBL:EDO15233.1, ECO:0000313|Proteomes:UP000000267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 /
RC NRRL Y-8283 / UCD 57-17 {ECO:0000313|Proteomes:UP000000267};
RX PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.;
RT "Independent sorting-out of thousands of duplicated gene pairs in two yeast
RT species descended from a whole-genome duplication.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Vacuole membrane
CC {ECO:0000256|ARBA:ARBA00004128}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004128}.
CC -!- SIMILARITY: Belongs to the amino acid/polyamine transporter 2 family.
CC {ECO:0000256|ARBA:ARBA00008066}.
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DR EMBL; DS480471; EDO15233.1; -; Genomic_DNA.
DR RefSeq; XP_001643091.1; XM_001643041.1.
DR AlphaFoldDB; A7TR65; -.
DR STRING; 436907.A7TR65; -.
DR GeneID; 5543310; -.
DR KEGG; vpo:Kpol_1029p6; -.
DR eggNOG; KOG1304; Eukaryota.
DR HOGENOM; CLU_009646_3_2_1; -.
DR InParanoid; A7TR65; -.
DR OMA; YWCYYIL; -.
DR OrthoDB; 3601817at2759; -.
DR PhylomeDB; A7TR65; -.
DR Proteomes; UP000000267; Unassembled WGS sequence.
DR GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR013057; AA_transpt_TM.
DR PANTHER; PTHR22950; AMINO ACID TRANSPORTER; 1.
DR PANTHER; PTHR22950:SF707; VACUOLAR AMINO ACID TRANSPORTER 4; 1.
DR Pfam; PF01490; Aa_trans; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000267};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 356..376
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 382..402
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 428..448
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 468..485
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 497..518
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 538..558
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 570..594
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 614..636
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 679..697
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 703..722
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 743..761
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 353..764
FT /note="Amino acid transporter transmembrane"
FT /evidence="ECO:0000259|Pfam:PF01490"
SQ SEQUENCE 767 AA; 87150 MW; 61C30C6F3D57929A CRC64;
MNHSSGTRND DKLTDSNAIT VDKFNSNIIN IRRGDRNLSS STNSKSIQIP NSAHNHSINS
KYLSVSGKNS WNKFTPVNNN INNNSSNLVK SLDARVLVDL SSPNFKTLDS EHHDLIVNSL
RNNYINRRSS IDTNETIHSG GISTKSVKTE ANLNSNITAI DDDDDCDNRI ERNISTQGGD
ITRDIYKLAI SKRHGGSFSK SNSLRHSKSL ENLTAAEDRS RKHSRASHLN VPGGFRREYI
VQKMRQDYAI RDYGSQRRQS NYSLAGNSLN SDANSNETDK VPFLTRNFLE FLYIYGNFAG
ESFEDDFITE EIEQADVERD ERRPLLYGGP SHLVSESVVT KPMIQSVVGN TPTIKAFFLL
LKSFIGTGIL FLPRAFDNGG LIFSICMLLF FGIYSYWCYY ILIRSKNITQ VTSFGDIGYK
LYGRWMKFVI LFSLVLTQLG FAGAYVIFTA KNLKAFVENV FRVPDFDLKY LMIFQLFIFT
PLSYVRNVSK LSFPSLVANF FIMSGLAIVI VFTMKHLFYD LNMRPEEGVI YGFNSNGWTL
FIGTAIFAFE GIGLIIPIQD SMKHPEHFPL VLGLVIMTAT VLFVTIATIG YLAYGKLIET
VILLNLPKSN IFVNLIQLFY SMAIMLSTPL QLFPAIKIIE NKVFPKFTKY YVKIDQTREG
VRLRQNSGKL DWRVKWRKNF LRSVIVLIVI LMAYYGYDDL DRFVSIIGSF ACIPLVYMYP
PMLHLRSYSI PSSEGLKIKY RVILDYILIA FGGVSMLYTS YQSLMSN
//
