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Database: UniProt
Entry: A7TRT0_VANPO
LinkDB: A7TRT0_VANPO
Original site: A7TRT0_VANPO 
ID   A7TRT0_VANPO            Unreviewed;       892 AA.
AC   A7TRT0;
DT   02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT   02-OCT-2007, sequence version 1.
DT   24-JAN-2024, entry version 105.
DE   RecName: Full=DNA replication licensing factor MCM2 {ECO:0000256|ARBA:ARBA00018925};
DE            EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN   ORFNames=Kpol_1007p8 {ECO:0000313|EMBL:EDO15024.1};
OS   Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS
OS   2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Vanderwaltozyma.
OX   NCBI_TaxID=436907 {ECO:0000313|Proteomes:UP000000267};
RN   [1] {ECO:0000313|EMBL:EDO15024.1, ECO:0000313|Proteomes:UP000000267}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 /
RC   NRRL Y-8283 / UCD 57-17 {ECO:0000313|Proteomes:UP000000267};
RX   PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA   Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.;
RT   "Independent sorting-out of thousands of duplicated gene pairs in two yeast
RT   species descended from a whole-genome duplication.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   EMBL; DS480487; EDO15024.1; -; Genomic_DNA.
DR   RefSeq; XP_001642882.1; XM_001642832.1.
DR   AlphaFoldDB; A7TRT0; -.
DR   STRING; 436907.A7TRT0; -.
DR   GeneID; 5543077; -.
DR   KEGG; vpo:Kpol_1007p8; -.
DR   eggNOG; KOG0477; Eukaryota.
DR   HOGENOM; CLU_000995_0_0_1; -.
DR   InParanoid; A7TRT0; -.
DR   OMA; NTDQGFP; -.
DR   OrthoDB; 5476523at2759; -.
DR   PhylomeDB; A7TRT0; -.
DR   Proteomes; UP000000267; Unassembled WGS sequence.
DR   GO; GO:0071162; C:CMG complex; IEA:UniProt.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR   GO; GO:0042555; C:MCM complex; IEA:InterPro.
DR   GO; GO:0005656; C:nuclear pre-replicative complex; IEA:UniProt.
DR   GO; GO:0031298; C:replication fork protection complex; IEA:UniProt.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProt.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006268; P:DNA unwinding involved in DNA replication; IEA:UniProt.
DR   GO; GO:0000727; P:double-strand break repair via break-induced replication; IEA:UniProt.
DR   GO; GO:0006267; P:pre-replicative complex assembly involved in nuclear cell cycle DNA replication; IEA:UniProt.
DR   GO; GO:0030174; P:regulation of DNA-templated DNA replication initiation; IEA:UniProt.
DR   CDD; cd17753; MCM2; 1.
DR   Gene3D; 2.20.28.10; -; 1.
DR   Gene3D; 3.30.1640.10; mini-chromosome maintenance (MCM) complex, chain A, domain 1; 1.
DR   Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR031327; MCM.
DR   InterPro; IPR008045; MCM2.
DR   InterPro; IPR018525; MCM_CS.
DR   InterPro; IPR001208; MCM_dom.
DR   InterPro; IPR041562; MCM_lid.
DR   InterPro; IPR027925; MCM_N.
DR   InterPro; IPR033762; MCM_OB.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11630; DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER; 1.
DR   PANTHER; PTHR11630:SF44; DNA REPLICATION LICENSING FACTOR MCM2; 1.
DR   Pfam; PF00493; MCM; 1.
DR   Pfam; PF12619; MCM2_N; 1.
DR   Pfam; PF17855; MCM_lid; 1.
DR   Pfam; PF14551; MCM_N; 1.
DR   Pfam; PF17207; MCM_OB; 1.
DR   PRINTS; PR01657; MCMFAMILY.
DR   PRINTS; PR01658; MCMPROTEIN2.
DR   SMART; SM00350; MCM; 1.
DR   SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS00847; MCM_1; 1.
DR   PROSITE; PS50051; MCM_2; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000267};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT   DOMAIN          519..725
FT                   /note="MCM"
FT                   /evidence="ECO:0000259|PROSITE:PS50051"
FT   REGION          1..128
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          729..761
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        34..51
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        73..98
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        99..128
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   892 AA;  101006 MW;  7E542FEC01FF251D CRC64;
     MSDNGSDSNN NNNNRRRRRD QDYDDDDDDA NRDVSNVNNG FPPSSPQHGG YAPSSPVGIA
     PSSPIGAPAE MMNPEGEDDE IEEIPDLEEL EEQMNEVDLM GDDMYRDYDD DPDKDRYDTQ
     GVDDREQTEL SLADRRRIDR QLNDRDRLLR KSAYLDEEEE EDGDGGQLDE MGLPVQRRRR
     RRQYEDLEHS DDDLLSDLDI DPLAEELTLE SLSNVKAISY SEWITQPNVA RTIARELKLF
     LLEYTDESGR SVYGARIRTL GEINSESLEV NYRHLAASKA ILALFLAKCP EEMLKIFDMV
     AMEATELHYP DYSRIHSEIH VRISDFPAVH NLRELRESNL SSLVRVTGVV TRRTGVFPQL
     KYVKFNCLKC GSVLGPYFQD SNEEIKISFC PNCKSKGPFN MNGEKTVYRN YQRITLQEAP
     GTVPAGRLPR HREIILLADL VDVAKPGEEV EITGIYKNNY DGNLNAKNGF PVFATIIEAN
     SIRRREGNSA NIDEEGLDIF SWTEDEEREF RKLSRDRGII DKIISSMAPS IYGHKDIKTA
     IACSLFGGVP KNVNGKHSIR GDINVLLLGD PGTAKSQILK YVEKTAHRAV FATGQGASAV
     GLTASVRKDP ITKEWTLEGG ALVLADKGVC LIDEFDKMND QDRTSIHEAM EQQSISISKA
     GIITTLQARC SIIAAANPNG GRYNSTLSLA QNVNLTEPIL SRFDILCVVR DLVDEEADER
     LATFVVDSHA RSHPENEVEN DNEEKMEVDG NNEEDENVPN LSARQKRIER LRKKEEEISP
     IPQEFLLKYI HYARTKIFPK LHQMDMDKVS RVYADLRRES ITTGSFPITV RHLESILRIA
     ESFAKMRLSE FVSSWDLDRA IRVVVDSFVD AQKISVRRQL QRSFAIYTLG QR
//
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