ID A7TS06_VANPO Unreviewed; 694 AA.
AC A7TS06;
DT 02-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 02-OCT-2007, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EDO14953.1};
GN ORFNames=Kpol_365p9 {ECO:0000313|EMBL:EDO14953.1};
OS Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS
OS 2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Vanderwaltozyma.
OX NCBI_TaxID=436907 {ECO:0000313|Proteomes:UP000000267};
RN [1] {ECO:0000313|EMBL:EDO14953.1, ECO:0000313|Proteomes:UP000000267}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 /
RC NRRL Y-8283 / UCD 57-17 {ECO:0000313|Proteomes:UP000000267};
RX PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.;
RT "Independent sorting-out of thousands of duplicated gene pairs in two yeast
RT species descended from a whole-genome duplication.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC 2.A.66.1) family. {ECO:0000256|ARBA:ARBA00010199}.
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DR EMBL; DS480493; EDO14953.1; -; Genomic_DNA.
DR RefSeq; XP_001642811.1; XM_001642761.1.
DR AlphaFoldDB; A7TS06; -.
DR STRING; 436907.A7TS06; -.
DR GeneID; 5542990; -.
DR KEGG; vpo:Kpol_365p9; -.
DR eggNOG; KOG1347; Eukaryota.
DR HOGENOM; CLU_012893_1_2_1; -.
DR InParanoid; A7TS06; -.
DR OMA; KISHHHI; -.
DR OrthoDB; 661905at2759; -.
DR PhylomeDB; A7TS06; -.
DR Proteomes; UP000000267; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR GO; GO:1990961; P:xenobiotic detoxification by transmembrane export across the plasma membrane; IEA:InterPro.
DR CDD; cd13132; MATE_eukaryotic; 1.
DR InterPro; IPR045069; MATE_euk.
DR InterPro; IPR002528; MATE_fam.
DR NCBIfam; TIGR00797; matE; 1.
DR PANTHER; PTHR11206:SF197; AEL099WP; 1.
DR PANTHER; PTHR11206; MULTIDRUG RESISTANCE PROTEIN; 1.
DR Pfam; PF01554; MatE; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000267};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 309..334
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 340..361
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 373..395
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 401..429
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 488..508
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 529..548
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 601..621
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 627..649
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 667..694
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 667..686
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 694 AA; 78231 MW; 73B34BAE51B6A484 CRC64;
MAALLSKTLS HVHSNLRTNG MGIGNTHRRI SLGFFPPNNK NPLVRKYRKS KRSRNDQRSY
MSLGDDFGSS VRESVAYPYL DDVLEENESW YGEDAGELSE TISLPSRISE TPDYTSVNMD
WILQEHDRRY SSVYNSDNED QEALNDIESH NQREFEYAEF MHQLHAQKKA HHLASQEFNG
KRRRRQSYVS VNSRGTVPTI YQEFDEHEEE QLQELNNEEI TYKSESYIIS SYSLPLIFTF
LLEQIFPMVC SLTVGHLGKN ELAAVSLASM TSNITLAVFE GIATSLDTLC PQAYGSGRYL
SVGIHLQRCI LFSFIIYIPF ALMWFFSEPI LMFFVPEKEL ISLTAQFLRV LILGAPGYIC
FENLKRFLQA QGIFDAGIYV LAFCAPLNVL LSYLLVWNKY IGIGFIGSAV AVVINFWLMF
FLLLLYTIYI DGMKCWGGFS KKAFTHWKDL GQLALSGIIM LEAEELSYEL LTLFSSYFGT
SYLAAQSAVS TMAALLYMVP FAVGIATSTR IANFVGAKRI DCAQISAKVG LMFSGLAGLI
NCSLLILTRD YIANLFSRDE EVISLIRNLL PLVGVIQNFD ALNAVAGSCL RGQGMQALGS
IINLVVYYLF AIPFGMSLSY FGDLKLYGLW IGIGSGMLLI GLIEAYYVLN PNWDSILNYA
EMLKESEEDD SDYEDNISDS DSDEEGEETP LLRR
//
