ID A7US43_ANOGA Unreviewed; 1241 AA.
AC A7US43;
DT 23-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 23-OCT-2007, sequence version 1.
DT 27-MAR-2024, entry version 101.
DE SubName: Full=AGAP011217-PA {ECO:0000313|EMBL:EDO64464.1};
GN ORFNames=AgaP_AGAP011217 {ECO:0000313|EMBL:EDO64464.1};
OS Anopheles gambiae (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7165 {ECO:0000313|EMBL:EDO64464.1};
RN [1] {ECO:0000313|EMBL:EDO64464.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PEST {ECO:0000313|EMBL:EDO64464.1};
RX PubMed=12364791; DOI=10.1126/science.1076181;
RA Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA Collins F.H., Hoffman S.L.;
RT "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL Science 298:129-149(2002).
RN [2] {ECO:0000313|EMBL:EDO64464.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EDO64464.1};
RG The Anopheles Genome Sequencing Consortium;
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:EDO64464.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EDO64464.1};
RX PubMed=14747013; DOI=10.1016/j.pt.2003.11.003;
RA Mongin E., Louis C., Holt R.A., Birney E., Collins F.H.;
RT "The Anopheles gambiae genome: an update.";
RL Trends Parasitol. 20:49-52(2004).
RN [4] {ECO:0000313|EMBL:EDO64464.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EDO64464.1};
RX PubMed=17210077; DOI=10.1186/gb-2007-8-1-r5;
RA Sharakhova M.V., Hammond M.P., Lobo N.F., Krzywinski J., Unger M.F.,
RA Hillenmeyer M.E., Bruggner R.V., Birney E., Collins F.H.;
RT "Update of the Anopheles gambiae PEST genome assembly.";
RL Genome Biol. 8:R5.1-R5.13(2007).
RN [5] {ECO:0000313|EMBL:EDO64464.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PEST {ECO:0000313|EMBL:EDO64464.1};
RG VectorBase;
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDO64464.1}.
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DR EMBL; AAAB01008816; EDO64464.1; -; Genomic_DNA.
DR RefSeq; XP_001688187.1; XM_001688135.1.
DR AlphaFoldDB; A7US43; -.
DR STRING; 7165.A7US43; -.
DR PaxDb; 7165-AGAP011217-PA; -.
DR GeneID; 5667908; -.
DR KEGG; aga:AgaP_AGAP011217; -.
DR VEuPathDB; VectorBase:AGAP011217; -.
DR eggNOG; KOG0314; Eukaryota.
DR eggNOG; KOG2217; Eukaryota.
DR HOGENOM; CLU_266697_0_0_1; -.
DR InParanoid; A7US43; -.
DR OMA; KITTPKM; -.
DR OrthoDB; 150979at2759; -.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR CDD; cd16620; vRING-HC-C4C4_RBBP6; 1.
DR Gene3D; 4.10.60.10; Zinc finger, CCHC-type; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR014891; DWNN_domain.
DR InterPro; IPR025829; Zn_knuckle_CX2CX3GHX4C.
DR InterPro; IPR001878; Znf_CCHC.
DR InterPro; IPR036875; Znf_CCHC_sf.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR15439; RETINOBLASTOMA-BINDING PROTEIN 6; 1.
DR PANTHER; PTHR15439:SF0; SOMETHING THAT STICKS LIKE GLUE, ISOFORM A; 1.
DR Pfam; PF08783; DWNN; 1.
DR Pfam; PF13923; zf-C3HC4_2; 1.
DR Pfam; PF13696; zf-CCHC_2; 1.
DR SMART; SM01180; DWNN; 1.
DR SMART; SM00184; RING; 1.
DR SMART; SM00343; ZnF_C2HC; 1.
DR SUPFAM; SSF57756; Retrovirus zinc finger-like domains; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS51282; DWNN; 1.
DR PROSITE; PS50158; ZF_CCHC; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00047}.
FT DOMAIN 3..76
FT /note="DWNN"
FT /evidence="ECO:0000259|PROSITE:PS51282"
FT DOMAIN 163..178
FT /note="CCHC-type"
FT /evidence="ECO:0000259|PROSITE:PS50158"
FT DOMAIN 231..272
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 96..115
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 266..285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 296..409
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 477..508
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 570..960
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 976..1241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 296..310
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 319..347
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 481..497
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 611..884
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 885..900
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 901..928
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 990..1039
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1052..1142
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1147..1174
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1186..1202
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1203..1219
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1220..1241
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1241 AA; 141012 MW; CEB2E4462F6225C3 CRC64;
MSVHYKFKSA LDFDTITFDG LHISVADLKK GIIQQKRLGK TVDFDLQITN AQTKEEYNDD
NMLIPKNTSL TIARVPVKNT GKKNWEKAAA AAAAAAEANA PSSAPRGKHD AASSQTNVDL
SMMNGTEEDK IREMMFQSTA EYDPTNYQKV RGTQTGEVPM NYKCYRCHKP GHWIKNCPLG
PLPKESIEVK RTSGIPRSFI ERDKEMGNNP AMQPVQMPPE EKQSIPEDLI CGICKDLFTD
AVMIPCCGSS FCDECVRTAL LESEDNECPD CKEKGSSPGS LIPNRFLRNS VNAFRNETGY
TKSQPKANVG KKQTKPEETP TADSTTTTSA RDADSNLQPQ LFDEISQQDD IGSPGREEKE
AMVAGGGPTG GFDNESDYED NITEGEGYGG AGPNAGLLGE RGREYDERSP EYMHGGGGGR
GLMPHPQHNH PQHVQAIGTA MGHPGGGAYM GPGNGGYGGH VGHPQYAGAG GAGAYGMQQG
GGYPPQQQQQ QQQQRGYDHH GGMYPADRPP RMMYPMRGGG YMQHHPPHMR QRPMGPGPMG
GGYQTVLQTI GPGVIDDPLE AFNRIMREKE LRKKQEQQQQ QQMRRNRSPM GERGRRSRSF
DNGGRGGGPR GNSSDRRRTS RQRSPDRRRS PDDKHHPDER DRSAERHERS NRGSRSAGGG
GEHERDKQDR KHQPSEKDKR SEPVDQHGRR GGDERDHHHR ERGKERGENE RGGDHQRERE
RERDRDRQRD REREKDRNKE KERGDHAEHH DRDRDRRKEK EREKEKEKER EREKEREREK
VREKEREKER LRDREKERDK EKDRERGEKD REREKDRDKE KDRDMEKDRE REKEREKERE
KEREKEREKE REKERDREKD KDGKEVSKKK TRDSSDEDRR DRKKDRDKKK RKKEKEVEKR
KHKKERKEKD KERRSKDRRK ERKTMDEDGQ INSSTGEDGQ EGASPEDGSA GGDGDGLQLA
TGGKVTSEVL KRAENAIFTR AINAIRPIEI KKISGDRQKL NDGNGRGKPF SDRRRGSSRS
RSRTRDDSKR VDRNRSGGRH ESGSGGSKKP SESSNRRGRD DRQRDDDRPQ RDRKDAEPRR
NSRERSDNRK TEQQQQQRGR SRDRERDRDR GDNRGRRGDS RDRKGTRDAS GSSKRTKVEK
PSSGKGNKSA AGGSSSDTTS SDSESSSTDS SPDTDAGGGG GGGGTSSKKR KKRKHKKERK
RAKRSAATTE TDDESGGKRK KSKKKSKSSK KKKKSSKHKK D
//
