ID A7WK39_CAEEL Unreviewed; 315 AA.
AC A7WK39;
DT 23-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 23-OCT-2007, sequence version 1.
DT 27-MAR-2024, entry version 99.
DE RecName: Full=nicotinamidase {ECO:0000256|ARBA:ARBA00039017};
DE EC=3.5.1.19 {ECO:0000256|ARBA:ARBA00039017};
DE AltName: Full=Nicotinamide deamidase {ECO:0000256|ARBA:ARBA00043224};
GN Name=pnc-1 {ECO:0000313|EMBL:CCD70256.1,
GN ECO:0000313|WormBase:Y38C1AA.3b};
GN ORFNames=CELE_Y38C1AA.3 {ECO:0000313|EMBL:CCD70256.1}, Y38C1AA.3
GN {ECO:0000313|WormBase:Y38C1AA.3b};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CCD70256.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CCD70256.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD70256.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- PATHWAY: Cofactor biosynthesis; nicotinate biosynthesis; nicotinate
CC from nicotinamide: step 1/1. {ECO:0000256|ARBA:ARBA00037900}.
CC -!- SIMILARITY: Belongs to the isochorismatase family.
CC {ECO:0000256|ARBA:ARBA00006336}.
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DR EMBL; BX284604; CCD70256.1; -; Genomic_DNA.
DR RefSeq; NP_001122808.1; NM_001129336.2.
DR AlphaFoldDB; A7WK39; -.
DR SMR; A7WK39; -.
DR EPD; A7WK39; -.
DR PeptideAtlas; A7WK39; -.
DR EnsemblMetazoa; Y38C1AA.3b.1; Y38C1AA.3b.1; WBGene00021395.
DR EnsemblMetazoa; Y38C1AA.3b.2; Y38C1AA.3b.2; WBGene00021395.
DR UCSC; Y38C1AA.3a; c. elegans.
DR AGR; WB:WBGene00021395; -.
DR WormBase; Y38C1AA.3b; CE41520; WBGene00021395; pnc-1.
DR HOGENOM; CLU_068979_13_1_1; -.
DR OrthoDB; 47357at2759; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00021395; Expressed in germ line (C elegans) and 4 other cell types or tissues.
DR ExpressionAtlas; A7WK39; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IDA:WormBase.
DR GO; GO:0005634; C:nucleus; IDA:WormBase.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008936; F:nicotinamidase activity; IDA:WormBase.
DR GO; GO:0006769; P:nicotinamide metabolic process; IDA:WormBase.
DR GO; GO:0019363; P:pyridine nucleotide biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd01011; nicotinamidase; 1.
DR Gene3D; 3.40.50.850; Isochorismatase-like; 1.
DR InterPro; IPR000868; Isochorismatase-like.
DR InterPro; IPR036380; Isochorismatase-like_sf.
DR PANTHER; PTHR11080:SF2; LD05707P; 1.
DR PANTHER; PTHR11080; PYRAZINAMIDASE/NICOTINAMIDASE; 1.
DR Pfam; PF00857; Isochorismatase; 1.
DR SUPFAM; SSF52499; Isochorismatase-like hydrolases; 1.
PE 1: Evidence at protein level;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Proteomics identification {ECO:0007829|EPD:A7WK39,
KW ECO:0007829|PeptideAtlas:A7WK39};
KW Pyridine nucleotide biosynthesis {ECO:0000256|ARBA:ARBA00022642};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940}.
FT DOMAIN 74..291
FT /note="Isochorismatase-like"
FT /evidence="ECO:0000259|Pfam:PF00857"
SQ SEQUENCE 315 AA; 35428 MW; E1DC17F775D63338 CRC64;
MVHSDNSATT NNNTILGNQS LEAIPEQLSE LTGITVEESE RIMESWLGNR QLDLRTSVLF
DQEVLSRLRS LRVALLVVDF QNDFVDGSLK IGDGDAGQEP SSAITPLNEL LQLSSWDLVV
YTKDWHPHNH ISFLSQAHNS DRVMDEKDEN KTLGFFDSVQ FLKPIKTEQV LYPDHCIQKS
WGSDIHPEIY IADNAEYIMK GVDPYLDSYS AFNDNNGRSK TELEDLLRRE NIDAVVIAGL
AYDICVRFTC LDAVKQNFLA AVIPECSAGL TKKGIEESEM AFKKQGVAMI SKDEARGITE
GGFLPREWVQ RIVKK
//
