ID SKIT5_MOUSE Reviewed; 1461 AA.
AC A7XUY5; A7XUY9; A7XUZ2;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 23-OCT-2007, sequence version 1.
DT 27-MAR-2024, entry version 84.
DE RecName: Full=Selection and upkeep of intraepithelial T-cells protein 5;
DE Short=Skint-5;
DE Flags: Precursor;
GN Name=Skint5;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), AND TISSUE SPECIFICITY.
RC STRAIN=C57BL/6J;
RX PubMed=18408721; DOI=10.1038/ng.108;
RA Boyden L.M., Lewis J.M., Barbee S.D., Bas A., Girardi M., Hayday A.C.,
RA Tigelaar R.E., Lifton R.P.;
RT "Skint1, the prototype of a newly identified immunoglobulin superfamily
RT gene cluster, positively selects epidermal gammadelta T cells.";
RL Nat. Genet. 40:656-662(2008).
CC -!- FUNCTION: May act by engaging a cell surface molecule on immature T-
CC cells in the embryonic thymus. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1; Synonyms=A;
CC IsoId=A7XUY5-1; Sequence=Displayed;
CC Name=2; Synonyms=B;
CC IsoId=A7XUY5-2; Sequence=VSP_034883;
CC Name=3; Synonyms=C;
CC IsoId=A7XUY5-3; Sequence=VSP_034884, VSP_034885;
CC -!- TISSUE SPECIFICITY: Expressed in skin and, to a lower extent, testis.
CC {ECO:0000269|PubMed:18408721}.
CC -!- MISCELLANEOUS: Encoded by one of the 11 copies of Skint genes clustered
CC in the D1 region of the chromosome 4.
CC -!- SIMILARITY: Belongs to the SKINT family. {ECO:0000305}.
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DR EMBL; EU099301; ABU87899.1; -; mRNA.
DR EMBL; EU099302; ABU87900.1; -; mRNA.
DR EMBL; EU099303; ABU87901.1; -; mRNA.
DR RefSeq; NP_001161348.1; NM_001167876.1. [A7XUY5-1]
DR RefSeq; NP_001161350.1; NM_001167878.1. [A7XUY5-2]
DR AlphaFoldDB; A7XUY5; -.
DR SMR; A7XUY5; -.
DR BioGRID; 232435; 2.
DR STRING; 10090.ENSMUSP00000132470; -.
DR GlyCosmos; A7XUY5; 1 site, No reported glycans.
DR GlyGen; A7XUY5; 1 site.
DR iPTMnet; A7XUY5; -.
DR PhosphoSitePlus; A7XUY5; -.
DR PaxDb; 10090-ENSMUSP00000132470; -.
DR GeneID; 242627; -.
DR KEGG; mmu:242627; -.
DR UCSC; uc009vcz.1; mouse. [A7XUY5-1]
DR UCSC; uc009vda.1; mouse. [A7XUY5-3]
DR UCSC; uc012diu.1; mouse. [A7XUY5-2]
DR AGR; MGI:3650151; -.
DR MGI; MGI:3650151; Skint5.
DR eggNOG; ENOG502SEQH; Eukaryota.
DR InParanoid; A7XUY5; -.
DR OrthoDB; 2943983at2759; -.
DR BioGRID-ORCS; 242627; 2 hits in 39 CRISPR screens.
DR ChiTaRS; Skint5; mouse.
DR PRO; PR:A7XUY5; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; A7XUY5; Protein.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR GO; GO:0001817; P:regulation of cytokine production; IBA:GO_Central.
DR GO; GO:0050852; P:T cell receptor signaling pathway; IBA:GO_Central.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR PANTHER; PTHR24100; BUTYROPHILIN; 1.
DR PANTHER; PTHR24100:SF146; SELECTION AND UPKEEP OF INTRAEPITHELIAL T-CELLS PROTEIN 5-RELATED; 1.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00406; IGv; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR PROSITE; PS50835; IG_LIKE; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; Disulfide bond; Glycoprotein; Immunoglobulin domain;
KW Membrane; Reference proteome; Repeat; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..1461
FT /note="Selection and upkeep of intraepithelial T-cells
FT protein 5"
FT /id="PRO_5000271637"
FT TOPO_DOM 25..1306
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 1307..1327
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1328..1345
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 1346..1366
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1367..1387
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 1388..1408
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1409..1427
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 1428..1448
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1449..1461
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT DOMAIN 26..139
FT /note="Ig-like V-type"
FT DOMAIN 142..231
FT /note="Ig-like C1-type"
FT CARBOHYD 200
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 49..123
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 163..217
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT VAR_SEQ 237..257
FT /note="VWDSWCPAWIMITLLIVIHMT -> KMCILSSLTATLTHTCYSIPS (in
FT isoform 3)"
FT /evidence="ECO:0000303|PubMed:18408721"
FT /id="VSP_034884"
FT VAR_SEQ 258..1461
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:18408721"
FT /id="VSP_034885"
FT VAR_SEQ 1235..1255
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:18408721"
FT /id="VSP_034883"
SQ SEQUENCE 1461 AA; 165918 MW; 0131DEB728175728 CRC64;
MGAVGIPLTA HCVVLFLLQM VALSSEQFTV NGLESPVLVP LDGNLELSCQ LSPPQQAKHM
EIRWFKNRYS EPVYLYRNGK DLFGEIVYKY VERTELLKDD IGKGKVTLRI FKVTSVDSGS
YHCFFKDGKF YEEHIIDVKV TATSSDIQIL MHPPNIKGVR LECHSGGWFP QPHMEWRDSK
GEYIPATSKS HSQDENEFFN MTMDLFIKSN SHWSATCYIQ NFVTHQEESI SIVLPGVWDS
WCPAWIMITL LIVIHMTYYI KLYRTYATKE MLLKSIQSSS QSSTVDTEKK EWLLKSIQSR
IQSSSVDAEK KEWLLKFIQS SIQSSSVDLE KKEWLLKSIQ SSIQSAIVDR GTKEWLLESI
QSSILSSIVD QGTKVLLLKS IQSSIQSSTL DIETKELLLK SIQSSIQSSI MDLGTKELLL
KIIQSSIQSS SVDLGTKELL LKIIQSSIQS STVDLGTKEL LLKIIQSSIQ SSSVDLGTKE
LLLKIIQSSI QSSTVDLGTK ELLLKIIQSS IQSSSVDLGA KMGLLESILS SIQSSNVDLE
TKVLLLKSIQ SSIQSSTVYL GIKQWLLERI ESIIQSSSVY LDTKELLLKI IQSSIESYSV
DLGNKEFLLK IILSSIQSSS VDLGTKELLV KFFQSNIQSS SVIPGTKKLL VKIIQSSLQS
SSVDLGTKKV LLDIIQTSIQ NSNVHTERKG LLLKIIQSSV QSSSVDQGTK EMLLEIIQSS
IQNSSVNQWT KDLLLKIIQS IIQSSSVDLG TKGFLLKIIQ SSIQSSSVDI GTKSMLLKKT
GLILKSSIVN PGTELLFQLI ESIRHSSSVN SETKKMLSEI TQSTVQSSSV NPVTEEMIEE
KYQLLLQSSS VNLEAENILN VTTQWILQIS SVNQGKEMLL LDKIQQILQI SSVNPETKDL
LLEKIELILQ NPGVHQETKD LLLERIQLIL QNSSVQKETK YLLLERIRSI LQSSCVQKET
KDLLLERIQS LLQSSCVQKE TKDLLLEKIQ LILQNSTVHQ ETKDLLLERI QLFLQNSTVD
QETSYLLLKR IQLILQSSSV KKETKEFVLY IIESILHSSS VHQETKDLLF DRVQLILESS
SVQQGLKCLL LNMIQVIFQR TSVQKEMKDL LFNRIPLILE SSSVQQETKD KLLDIIQSIL
QRTSVQEETK DKLLDIIQSI LQRSSVQKDT IDTLLDRIQL ILQRTSVQKE MKDFLLDRIK
SILESFSVHQ ETKKLLLNRI MSILESSTVH QETKKLLLER IQSILESSSV QQETKKLLLD
RIHSILKSSS VQKETKNLLL DRIHSILKSS SVQKESCNKR NPFWKKYALD LGISVFTIIV
VTLIMHLKQR EADQHFELNT LWSKDTSVIL CVLIMFNNRL KALIYFRLYG FSPPGKAHKY
IVNYILRFSH PVFCIVYSAT ILYMYLQIQN KDSLFSLYNS WMVEMEMVLI FLLVIFNVKN
IATVLLYFDS TTLRLFFWIK G
//
