ID A7ZFQ8_CAMC1 Unreviewed; 425 AA.
AC A7ZFQ8;
DT 23-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 23-OCT-2007, sequence version 1.
DT 27-MAR-2024, entry version 108.
DE RecName: Full=Citrate synthase {ECO:0000256|PIRNR:PIRNR001369, ECO:0000256|RuleBase:RU003370};
GN Name=gltA {ECO:0000313|EMBL:EAT97967.1};
GN ORFNames=CCC13826_2287 {ECO:0000313|EMBL:EAT97967.1};
OS Campylobacter concisus (strain 13826).
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Campylobacteraceae; Campylobacter.
OX NCBI_TaxID=360104 {ECO:0000313|EMBL:EAT97967.1, ECO:0000313|Proteomes:UP000001121};
RN [1] {ECO:0000313|Proteomes:UP000001121}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=13826 {ECO:0000313|Proteomes:UP000001121};
RA Fouts D.E., Mongodin E.F., Puiu D., Sebastian Y., Miller W.G.,
RA Mandrell R.E., On S., Nelson K.E.;
RT "Genome sequence of Campylobacter concisus 13826 isolated from human
RT feces.";
RL Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+);
CC Xref=Rhea:RHEA:16845, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16452, ChEBI:CHEBI:16947, ChEBI:CHEBI:57287,
CC ChEBI:CHEBI:57288; EC=2.3.3.16;
CC Evidence={ECO:0000256|ARBA:ARBA00000308,
CC ECO:0000256|RuleBase:RU003370};
CC -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate
CC from oxaloacetate: step 1/2. {ECO:0000256|ARBA:ARBA00004751,
CC ECO:0000256|RuleBase:RU003370}.
CC -!- SIMILARITY: Belongs to the citrate synthase family.
CC {ECO:0000256|ARBA:ARBA00010566, ECO:0000256|PIRNR:PIRNR001369,
CC ECO:0000256|RuleBase:RU003406}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP000792; EAT97967.1; -; Genomic_DNA.
DR RefSeq; WP_012140482.1; NC_009802.2.
DR AlphaFoldDB; A7ZFQ8; -.
DR STRING; 360104.CCC13826_2287; -.
DR KEGG; cco:CCC13826_2287; -.
DR eggNOG; COG0372; Bacteria.
DR HOGENOM; CLU_025068_0_0_7; -.
DR OrthoDB; 9800864at2; -.
DR UniPathway; UPA00223; UER00717.
DR Proteomes; UP000001121; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0004108; F:citrate (Si)-synthase activity; IEA:InterPro.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway.
DR CDD; cd06114; EcCS_like; 1.
DR Gene3D; 2.20.28.60; -; 1.
DR Gene3D; 1.10.580.10; Citrate Synthase, domain 1; 1.
DR Gene3D; 1.10.230.10; Cytochrome P450-Terp, domain 2; 1.
DR InterPro; IPR016142; Citrate_synth-like_lrg_a-sub.
DR InterPro; IPR016143; Citrate_synth-like_sm_a-sub.
DR InterPro; IPR002020; Citrate_synthase.
DR InterPro; IPR019810; Citrate_synthase_AS.
DR InterPro; IPR024176; Citrate_synthase_bac-typ.
DR InterPro; IPR036969; Citrate_synthase_sf.
DR InterPro; IPR010953; Citrate_synthase_typ-I.
DR NCBIfam; TIGR01798; cit_synth_I; 1.
DR PANTHER; PTHR42871; CITRATE SYNTHASE; 1.
DR PANTHER; PTHR42871:SF1; CITRATE SYNTHASE; 1.
DR Pfam; PF00285; Citrate_synt; 1.
DR PIRSF; PIRSF001369; Citrate_synth; 1.
DR PRINTS; PR00143; CITRTSNTHASE.
DR SUPFAM; SSF48256; Citrate synthase; 1.
DR PROSITE; PS00480; CITRATE_SYNTHASE; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000313|EMBL:EAT97967.1};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR001369};
KW Tricarboxylic acid cycle {ECO:0000256|ARBA:ARBA00022532,
KW ECO:0000256|RuleBase:RU003370}.
FT ACT_SITE 308
FT /evidence="ECO:0000256|PIRSR:PIRSR001369-1"
FT ACT_SITE 365
FT /evidence="ECO:0000256|PIRSR:PIRSR001369-1"
SQ SEQUENCE 425 AA; 48265 MW; 1EA4D199AB943695 CRC64;
MSSNTATLTD NRTGKSYEFP ILKGTMGPDV IDISTFFSDT GMFTFDRGYT STAMCRSAIT
YIDGLKGELM YRGYDIAYLA ENKTFLDVAY LLLNKELPTG EQYKGFKDEL KKRSFIHEGM
MKLFDAFPDK AHPMAILQAA VSALSAFYSD HLNMDKPEEY HEMAMRIIAK IPTIAAFSYR
YSRGLPIIYP NLDRGFTENF LYMMRGYPYE HVDLKPIEIK ALDTVFMLHA DHEQNASTTT
VRTVGSTHAH PYACISAGIG ALWGWAHGGA NEGVIRQLEE IGSVANVDKY IARAKDKNDP
FRLMGFGHRV YKNFDPRAKV LKKMRDQLMD EIGISSELIK IANRIEEIAL NDDYFVSRNL
YPNVDFHSGL ILKALGIPNN MFAVIFVIGR TPGWISQWIE LKEQDTIKIV RPRQLYVGET
NRTPK
//
