ID A8AEC6_CITK8 Unreviewed; 430 AA.
AC A8AEC6;
DT 23-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 23-OCT-2007, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE RecName: Full=Major facilitator superfamily (MFS) profile domain-containing protein {ECO:0000259|PROSITE:PS50850};
GN OrderedLocusNames=CKO_00685 {ECO:0000313|EMBL:ABV11839.1};
OS Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Citrobacter.
OX NCBI_TaxID=290338 {ECO:0000313|EMBL:ABV11839.1, ECO:0000313|Proteomes:UP000008148};
RN [1] {ECO:0000313|EMBL:ABV11839.1, ECO:0000313|Proteomes:UP000008148}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-895 / CDC 4225-83 / SGSC4696
RC {ECO:0000313|Proteomes:UP000008148};
RG The Citrobacter koseri Genome Sequencing Project;
RA McClelland M., Sanderson E.K., Porwollik S., Spieth J., Clifton W.S.,
RA Latreille P., Courtney L., Wang C., Pepin K., Bhonagiri V., Nash W.,
RA Johnson M., Thiruvilangam P., Wilson R.;
RL Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP000822; ABV11839.1; -; Genomic_DNA.
DR AlphaFoldDB; A8AEC6; -.
DR STRING; 290338.CKO_00685; -.
DR KEGG; cko:CKO_00685; -.
DR HOGENOM; CLU_013133_1_2_6; -.
DR Proteomes; UP000008148; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005337; F:nucleoside transmembrane transporter activity; IEA:InterPro.
DR CDD; cd06177; MFS_NHS; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 2.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR004740; Nuc_H_symport.
DR NCBIfam; TIGR00889; 2A0110; 1.
DR PANTHER; PTHR23522; BLL5896 PROTEIN; 1.
DR PANTHER; PTHR23522:SF4; NUCLEOSIDE PERMEASE NUPG-RELATED; 1.
DR Pfam; PF03825; Nuc_H_symport; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS50850; MFS; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008148};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..34
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 46..63
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 75..91
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 103..125
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 137..155
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 167..186
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 216..237
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 249..267
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 279..299
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 305..330
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 342..361
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 381..405
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 199..430
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
SQ SEQUENCE 430 AA; 47990 MW; F5D31CA21612FEB8 CRC64;
MKDLTMKTTV KLSFMMFVEW FIWGAWFVPL WLWLNKSGFS AGEIGWSYAC TAIAAILSPI
LVGSLTDRFF SAQKVLAVLM FAGAVLMYFA AQQTTFAGFF PLLLAYSLTY MPTIALTNSI
AFANVPDVER DFPRIRVMGT IGWIASGLAC GFLPQMLGYN DISPTNIPLL ITAGSSVLLG
AFAFFLPDTP PKSTGKLDIK VMLGLDALIL LRDKNFLVFF FCSFLFAMPL AFYYIFANGY
LTEVGMKNAT GWMTLGQFSE IFFMLALPFF TKRFGIKKVL LLGLITAAIR YGFFVYGGAE
EYFTYALLFL GILLHGVSYD FYYVTAYIYV DKKASVHMRT AAQGLITLCC QGFGSLLGYR
LGGVMMEKMF AYKEPVNGLT FNWAGMWTFG AVMIAVIAVL FMIFFRESDK EITAIKVDDR
DIALTQGEVK
//
