ID A8AEW1_CITK8 Unreviewed; 819 AA.
AC A8AEW1;
DT 23-OCT-2007, integrated into UniProtKB/TrEMBL.
DT 23-OCT-2007, sequence version 1.
DT 27-MAR-2024, entry version 88.
DE RecName: Full=Ketosynthase family 3 (KS3) domain-containing protein {ECO:0000259|PROSITE:PS52004};
GN OrderedLocusNames=CKO_00874 {ECO:0000313|EMBL:ABV12024.1};
OS Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Citrobacter.
OX NCBI_TaxID=290338 {ECO:0000313|EMBL:ABV12024.1, ECO:0000313|Proteomes:UP000008148};
RN [1] {ECO:0000313|EMBL:ABV12024.1, ECO:0000313|Proteomes:UP000008148}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-895 / CDC 4225-83 / SGSC4696
RC {ECO:0000313|Proteomes:UP000008148};
RG The Citrobacter koseri Genome Sequencing Project;
RA McClelland M., Sanderson E.K., Porwollik S., Spieth J., Clifton W.S.,
RA Latreille P., Courtney L., Wang C., Pepin K., Bhonagiri V., Nash W.,
RA Johnson M., Thiruvilangam P., Wilson R.;
RL Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP
CC synthases family. {ECO:0000256|ARBA:ARBA00008467}.
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DR EMBL; CP000822; ABV12024.1; -; Genomic_DNA.
DR RefSeq; WP_001029878.1; NC_009792.1.
DR AlphaFoldDB; A8AEW1; -.
DR SMR; A8AEW1; -.
DR STRING; 290338.CKO_00874; -.
DR GeneID; 45135064; -.
DR KEGG; cko:CKO_00874; -.
DR HOGENOM; CLU_000022_16_6_6; -.
DR OrthoDB; 6437095at2; -.
DR Proteomes; UP000008148; Chromosome.
DR GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:UniProtKB-KW.
DR GO; GO:1901576; P:organic substance biosynthetic process; IEA:UniProt.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Reference proteome {ECO:0000313|Proteomes:UP000008148};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 10..424
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
SQ SEQUENCE 819 AA; 89564 MW; 6950A362E70EFEAC CRC64;
MAKDDFTCGS LDIAIIGMSG RFSGAESVPE WWDKLLAGEE FTQPTCTEDD NGNPWIRLRN
IITAPYDFDA AFFNIPPGEA LLMDPQQRIF LECCYNALEH AGYIPTQLKR VGVYGATYAN
NYFIDRVYPY LKMSGDHHYL QAQIGNEKDY LCAQVAYKLG FTGPAVSVQT ACSSSLVAAY
LACEGLLTFQ ADVALAGGVT LGFLQAHGYS PQGDKLVSQD GHCAPFSAEA TGTVYSSGAG
VVVLKRLEDA LRDQDRVYAV IKGGAVNNDG GRRLGFVAPS VEGQVEAINT ALAAAEVVPT
DIALIETHGT GTPLGDEIEL EALHRVFAPA CAPHSIQLGA VKANLGHLGV ASGIVSLMKT
ALTLYTGLVP PQINLVNKHK KLLQPASPFY LSDVVTSVPQ TKRIHATVSS FGLGGTNAHL
VLQNWCETPA QAVQENERRL FFFSAKTPLA LRQQLDAHYH ALATYAEADK DRIAYTLAQR
RAHFPYRCAL AADSVVALRA SLAKLRDADM SFTPINMETT LVFLYPDRDD KLESALTHLL
ACQPNLRQRH QRLSQDVAQI CEPADWTPAL RQFIQQVSLS EWLIEQSISP VQHIGYLTGA
AAAQYVARII SLENAVQQVI VAETTPEQTL AGNSELSEIL ANLAVTEGTL MLEIGRAGTF
SILYHQHAQW VGQTVFSPML NTDTPEDILP LLGTLWQRGV TICLPEMPAV QTIGLPGYSF
DRVRYEIQSS DARENAMLPV SYLSVSDFVE KTWRSLLCID HYDEHAVIFE YGATSMHVIS
FVDSCNHIYK IGLTAADIYA RPAIREHSEF ISECVDGIL
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