ID A8B3C3_GIAIC Unreviewed; 767 AA.
AC A8B3C3;
DT 13-NOV-2007, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2007, sequence version 1.
DT 24-JAN-2024, entry version 48.
DE SubName: Full=Serine esterase {ECO:0000313|EMBL:KAE8303141.1};
GN ORFNames=GL50803_0014104 {ECO:0000313|EMBL:KAE8303141.1},
GN GL50803_14104 {ECO:0000313|EMBL:EDO82506.1};
OS Giardia intestinalis (strain ATCC 50803 / WB clone C6) (Giardia lamblia).
OC Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX NCBI_TaxID=184922 {ECO:0000313|EMBL:EDO82506.1};
RN [1] {ECO:0000313|EMBL:EDO82506.1, ECO:0000313|Proteomes:UP000001548}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50803 / WB clone C6 {ECO:0000313|Proteomes:UP000001548},
RC and WB C6 {ECO:0000313|EMBL:EDO82506.1};
RX PubMed=17901334; DOI=10.1126/science.1143837;
RA Morrison H.G., McArthur A.G., Gillin F.D., Aley S.B., Adam R.D.,
RA Olsen G.J., Best A.A., Cande W.Z., Chen F., Cipriano M.J., Davids B.J.,
RA Dawson S.C., Elmendorf H.G., Hehl A.B., Holder M.E., Huse S.M., Kim U.U.,
RA Lasek-Nesselquist E., Manning G., Nigam A., Nixon J.E., Palm D.,
RA Passamaneck N.E., Prabhu A., Reich C.I., Reiner D.S., Samuelson J.,
RA Svard S.G., Sogin M.L.;
RT "Genomic minimalism in the early diverging intestinal parasite Giardia
RT lamblia.";
RL Science 317:1921-1926(2007).
RN [2] {ECO:0000313|EMBL:KAE8303141.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=WB C6 {ECO:0000313|EMBL:KAE8303141.1};
RA Xu F., Jex A., Svard S.G.;
RT "New Giardia intestinalis WB genome in near-complete chromosomes.";
RL Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDO82506.1}.
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DR EMBL; AACB02000001; EDO82506.1; -; Genomic_DNA.
DR EMBL; AACB03000003; KAE8303141.1; -; Genomic_DNA.
DR RefSeq; XP_001710180.1; XM_001710128.1.
DR AlphaFoldDB; A8B3C3; -.
DR ESTHER; giaia-e1f0e1; Duf_676.
DR EnsemblProtists; EDO82506; EDO82506; GL50803_14104.
DR GeneID; 5703107; -.
DR KEGG; gla:GL50803_0014104; -.
DR VEuPathDB; GiardiaDB:GL50803_14104; -.
DR HOGENOM; CLU_364277_0_0_1; -.
DR OMA; YTELACQ; -.
DR Proteomes; UP000001548; Chromosome 3.
DR GO; GO:0044255; P:cellular lipid metabolic process; IBA:GO_Central.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR007751; DUF676_lipase-like.
DR InterPro; IPR044294; Lipase-like.
DR PANTHER; PTHR12482:SF5; DUF676 DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR12482; UNCHARACTERIZED; 1.
DR Pfam; PF05057; DUF676; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001548}.
FT DOMAIN 520..648
FT /note="DUF676"
FT /evidence="ECO:0000259|Pfam:PF05057"
FT REGION 219..255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 386..414
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 222..255
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 400..414
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 767 AA; 85452 MW; 52BDE2B9392F315D CRC64;
MSKEKSELNA YCLQVVVGSM FVGYNAPRGY YVLKVSVKDH RKIKYVAVSS IKSFLLPTQT
KDCLTRYKVT TQIIGIEQNC YHSEPFYIHE GNQTIHFNTI LTFTVGSKNR QISCAVISFK
LYYVPFPKEF DSVEKIINAD ESQYIKAFDQ SLFENPKLST VMKRRCYLDN FCVPFAGYHI
ETFNVTDNFK LECFVSNFLT SEKTKLMIYD MNGVVSESTD LSDNLEDPRR VLSGKDEEEE
DDAGKKRDTG KGGSERQLKK FLNKSRVEST DISQRYNSLK TILYDVCGCT VEKDPILNSV
VVSIDNVAVT PLNIAFVLKA ARSVYLKMLP SFRAQFYGYL THQDLKAMFQ APDAHNDSYY
TELACQYRKA IRALYSPQTS MITSRVEDAV EDSDRSEQSS RASSRSASVS ASSGAVNPSY
GNIPYKPTVS TSSAMPTKSE LLDIIMQNRK LYPYVRPEKY VIEAPIVFVR SYTQGSAPTD
DKLTVASLEP PVANNVYYAV SSNVKSARKL LSADLDKINV YIYLHGLQAQ HLDMLAISEC
LATFRKGKSL DILCESYADS SAAPSKENAS KIYNEIFSKL SSRNVKLDSL QSINFIGHSL
GGLLCLKVAS MLPPDQQEKL GFLLTINAPI TGTTFKSNLV SMAVPFITGK MPVIKEMKDC
SSDGIIYTAA TQFPGFKQVY FVGTCGDGFV PFRCATGMGI TEDQVLISSL LAKNIKSSVV
KQAIVCFDAG ELKENGSGLN NIIGRTAHLR LLEDRQAFRM VLEALGF
//
