ID A8B4L5_GIAIC Unreviewed; 340 AA.
AC A8B4L5;
DT 13-NOV-2007, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2007, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Methyltransferase like 2 {ECO:0000313|EMBL:EDO81957.1};
GN ORFNames=GL50803_009528 {ECO:0000313|EMBL:KAE8303710.1}, GL50803_9528
GN {ECO:0000313|EMBL:EDO81957.1};
OS Giardia intestinalis (strain ATCC 50803 / WB clone C6) (Giardia lamblia).
OC Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX NCBI_TaxID=184922 {ECO:0000313|EMBL:EDO81957.1};
RN [1] {ECO:0000313|EMBL:EDO81957.1, ECO:0000313|Proteomes:UP000001548}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50803 / WB clone C6 {ECO:0000313|Proteomes:UP000001548},
RC and WB C6 {ECO:0000313|EMBL:EDO81957.1};
RX PubMed=17901334; DOI=10.1126/science.1143837;
RA Morrison H.G., McArthur A.G., Gillin F.D., Aley S.B., Adam R.D.,
RA Olsen G.J., Best A.A., Cande W.Z., Chen F., Cipriano M.J., Davids B.J.,
RA Dawson S.C., Elmendorf H.G., Hehl A.B., Holder M.E., Huse S.M., Kim U.U.,
RA Lasek-Nesselquist E., Manning G., Nigam A., Nixon J.E., Palm D.,
RA Passamaneck N.E., Prabhu A., Reich C.I., Reiner D.S., Samuelson J.,
RA Svard S.G., Sogin M.L.;
RT "Genomic minimalism in the early diverging intestinal parasite Giardia
RT lamblia.";
RL Science 317:1921-1926(2007).
RN [2] {ECO:0000313|EMBL:KAE8303710.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=WB C6 {ECO:0000313|EMBL:KAE8303710.1};
RA Xu F., Jex A., Svard S.G.;
RT "New Giardia intestinalis WB genome in near-complete chromosomes.";
RL Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily. METL family.
CC {ECO:0000256|ARBA:ARBA00009725}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDO81957.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AACB02000002; EDO81957.1; -; Genomic_DNA.
DR EMBL; AACB03000002; KAE8303710.1; -; Genomic_DNA.
DR RefSeq; XP_001709631.1; XM_001709579.1.
DR AlphaFoldDB; A8B4L5; -.
DR STRING; 184922.A8B4L5; -.
DR EnsemblProtists; EDO81957; EDO81957; GL50803_9528.
DR GeneID; 5702555; -.
DR KEGG; gla:GL50803_009528; -.
DR VEuPathDB; GiardiaDB:GL50803_9528; -.
DR HOGENOM; CLU_029724_0_2_1; -.
DR OMA; FVCDIAT; -.
DR Proteomes; UP000001548; Chromosome 4.
DR GO; GO:0008173; F:RNA methyltransferase activity; IEA:UniProt.
DR GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:UniProt.
DR GO; GO:0001510; P:RNA methylation; IEA:UniProt.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR013217; Methyltransf_12.
DR InterPro; IPR026113; METTL2/6/8-like.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR22809; METHYLTRANSFERASE-RELATED; 1.
DR PANTHER; PTHR22809:SF5; TRNA N(3)-METHYLCYTIDINE METHYLTRANSFERASE METTL6; 1.
DR Pfam; PF08242; Methyltransf_12; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:EDO81957.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001548};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:EDO81957.1}.
FT DOMAIN 128..239
FT /note="Methyltransferase type 12"
FT /evidence="ECO:0000259|Pfam:PF08242"
SQ SEQUENCE 340 AA; 38610 MW; 9643B0DE36B3FC22 CRC64;
MDFSANPCER GSTEAANEWN HVYTQHKGSL YRDRHWLWAV FPELFPLPPH YKGDLDTETF
ACHCGKATAI SSALVNEVNM HGLALRACCC PVCEYRVVYQ STYVYAPGRP TRGEEVPFPP
RTGHVWVLDI GCGTGSLAFP LLEKNSQVRL LSLDYSEEAI KVLKLRERYN EEVIVGEICD
ITSLQNLSAA CAQLATRFTP SPVFYYATMV FVLSALKDSN TVKTAISNVL SVLTDNGVLL
IYDYAEGDYR EGKFSAREQS SLDRSPMDRK NHYLGTTYLR GEGTRATFFY LEALKELCSE
LGVVHEALVR TKEEYNRKTQ ERWVKKYLLI KVRKSSHEQK
//
