ID A8B6N1_GIAIC Unreviewed; 686 AA.
AC A8B6N1;
DT 13-NOV-2007, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2007, sequence version 1.
DT 28-JUN-2023, entry version 59.
DE SubName: Full=Not1 N-terminal domain, CCR4-Not complex component-containing protein {ECO:0000313|EMBL:KAE8301886.1};
GN ORFNames=GL50803_008061 {ECO:0000313|EMBL:KAE8301886.1}, GL50803_8061
GN {ECO:0000313|EMBL:EDO81345.1};
OS Giardia intestinalis (strain ATCC 50803 / WB clone C6) (Giardia lamblia).
OC Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX NCBI_TaxID=184922 {ECO:0000313|EMBL:EDO81345.1};
RN [1] {ECO:0000313|EMBL:EDO81345.1, ECO:0000313|Proteomes:UP000001548}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50803 / WB clone C6 {ECO:0000313|Proteomes:UP000001548},
RC and WB C6 {ECO:0000313|EMBL:EDO81345.1};
RX PubMed=17901334; DOI=10.1126/science.1143837;
RA Morrison H.G., McArthur A.G., Gillin F.D., Aley S.B., Adam R.D.,
RA Olsen G.J., Best A.A., Cande W.Z., Chen F., Cipriano M.J., Davids B.J.,
RA Dawson S.C., Elmendorf H.G., Hehl A.B., Holder M.E., Huse S.M., Kim U.U.,
RA Lasek-Nesselquist E., Manning G., Nigam A., Nixon J.E., Palm D.,
RA Passamaneck N.E., Prabhu A., Reich C.I., Reiner D.S., Samuelson J.,
RA Svard S.G., Sogin M.L.;
RT "Genomic minimalism in the early diverging intestinal parasite Giardia
RT lamblia.";
RL Science 317:1921-1926(2007).
RN [2] {ECO:0000313|EMBL:KAE8301886.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=WB C6 {ECO:0000313|EMBL:KAE8301886.1};
RA Xu F., Jex A., Svard S.G.;
RT "New Giardia intestinalis WB genome in near-complete chromosomes.";
RL Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDO81345.1}.
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DR EMBL; AACB02000004; EDO81345.1; -; Genomic_DNA.
DR EMBL; AACB03000005; KAE8301886.1; -; Genomic_DNA.
DR RefSeq; XP_001709019.1; XM_001708967.1.
DR AlphaFoldDB; A8B6N1; -.
DR STRING; 184922.A8B6N1; -.
DR EnsemblProtists; EDO81345; EDO81345; GL50803_8061.
DR GeneID; 5701943; -.
DR KEGG; gla:GL50803_008061; -.
DR VEuPathDB; GiardiaDB:GL50803_8061; -.
DR HOGENOM; CLU_401412_0_0_1; -.
DR InParanoid; A8B6N1; -.
DR OMA; MCGSIES; -.
DR Proteomes; UP000001548; Chromosome 1.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR InterPro; IPR007207; Not_N.
DR Pfam; PF04065; Not3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000001548}.
FT DOMAIN 9..232
FT /note="CCR4-Not complex component Not N-terminal"
FT /evidence="ECO:0000259|Pfam:PF04065"
FT REGION 275..297
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 310..385
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 539..573
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 9..72
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 135..194
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 275..295
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 324..385
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 539..553
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 554..570
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 686 AA; 76812 MW; A95AA44540761A23 CRC64;
MSSTKGKHKQ QLQVEIEQVL SKVDELRTSF QQHWDKLENG TPANREKTEN LLRADLDKLK
RLRKQIQTLM DLPEVATTRN KLKRCTDAIE ADMRRHYILE RESKTKQFSN VALNDENEKR
AGPRASTQAW LDLCLTELNN RLEDLRSQLD GVQLQGSTKK NMKITKVNAA DKLIVKLEEH
KEQLEDIIAA YEEGYVTHAD IELYLKKSLD EVIRACKGGA DIDITTVIYD DIMDLIRTNR
MCGSIESFEE PAAEYTNWTP SSAKSPRSGN KIVKEVQSGN DKGTRSISPN PDQDDLDEIT
FSDASRVAAE GDAEAYVPMR DLSSNDRTEG QTTNTRQTMA PRQANKTTKQ GKSSFDIINS
EHVDGSKVSQ TQTQQQGLPP IKGVEQTNST RVVRPVFQMA SQLSYLRPSP LKENTLIYVP
AVTPAAMALY SLKLPKSLML CTKPHAFKDV VPDLPRSISL LSTQTSNEHQ ALNDVAAHNI
MLEFKYSERP ISKIWITMGT FNSERGKTKP YYTYNPGTSM MSKQQLTRLT NVRKAMTELR
TKGRAKRQDH QTPSLSDNND TGSTSSFDLD AGGSDPAHFT AEDGFHVASG TGEGPAVQDS
AAKSVSGGES VYPQVYSVRR FVNAPCALSS DHDLAETKWF ANRPSQALIW LVTNIDNNRI
RQLAAAGLQQ QGYRYDNGQW TRETVQ
//
