ID A8B6T4_GIAIC Unreviewed; 961 AA.
AC A8B6T4;
DT 13-NOV-2007, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2007, sequence version 1.
DT 24-JAN-2024, entry version 73.
DE SubName: Full=Histidyl-tRNA synthetase {ECO:0000313|EMBL:EDO81376.1};
GN ORFNames=GL50803_0022808 {ECO:0000313|EMBL:KAE8301866.1},
GN GL50803_22808 {ECO:0000313|EMBL:EDO81376.1};
OS Giardia intestinalis (strain ATCC 50803 / WB clone C6) (Giardia lamblia).
OC Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX NCBI_TaxID=184922 {ECO:0000313|EMBL:EDO81376.1};
RN [1] {ECO:0000313|EMBL:EDO81376.1, ECO:0000313|Proteomes:UP000001548}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50803 / WB clone C6 {ECO:0000313|Proteomes:UP000001548},
RC and WB C6 {ECO:0000313|EMBL:EDO81376.1};
RX PubMed=17901334; DOI=10.1126/science.1143837;
RA Morrison H.G., McArthur A.G., Gillin F.D., Aley S.B., Adam R.D.,
RA Olsen G.J., Best A.A., Cande W.Z., Chen F., Cipriano M.J., Davids B.J.,
RA Dawson S.C., Elmendorf H.G., Hehl A.B., Holder M.E., Huse S.M., Kim U.U.,
RA Lasek-Nesselquist E., Manning G., Nigam A., Nixon J.E., Palm D.,
RA Passamaneck N.E., Prabhu A., Reich C.I., Reiner D.S., Samuelson J.,
RA Svard S.G., Sogin M.L.;
RT "Genomic minimalism in the early diverging intestinal parasite Giardia
RT lamblia.";
RL Science 317:1921-1926(2007).
RN [2] {ECO:0000313|EMBL:KAE8301866.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=WB C6 {ECO:0000313|EMBL:KAE8301866.1};
RA Xu F., Jex A., Svard S.G.;
RT "New Giardia intestinalis WB genome in near-complete chromosomes.";
RL Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the class-II aminoacyl-tRNA synthetase family.
CC {ECO:0000256|ARBA:ARBA00008226}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDO81376.1}.
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DR EMBL; AACB02000004; EDO81376.1; -; Genomic_DNA.
DR EMBL; AACB03000005; KAE8301866.1; -; Genomic_DNA.
DR RefSeq; XP_001709050.1; XM_001708998.1.
DR AlphaFoldDB; A8B6T4; -.
DR STRING; 184922.A8B6T4; -.
DR EnsemblProtists; EDO81376; EDO81376; GL50803_22808.
DR GeneID; 5701968; -.
DR KEGG; gla:GL50803_0022808; -.
DR VEuPathDB; GiardiaDB:GL50803_22808; -.
DR HOGENOM; CLU_307671_0_0_1; -.
DR OMA; CATHREK; -.
DR Proteomes; UP000001548; Chromosome 1.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0004821; F:histidine-tRNA ligase activity; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0006427; P:histidyl-tRNA aminoacylation; IBA:GO_Central.
DR GO; GO:0032543; P:mitochondrial translation; IBA:GO_Central.
DR CDD; cd00773; HisRS-like_core; 1.
DR Gene3D; 3.40.50.800; Anticodon-binding domain; 1.
DR InterPro; IPR006195; aa-tRNA-synth_II.
DR InterPro; IPR045864; aa-tRNA-synth_II/BPL/LPL.
DR InterPro; IPR036621; Anticodon-bd_dom_sf.
DR InterPro; IPR041715; HisRS-like_core.
DR PANTHER; PTHR11476:SF7; HISTIDINE--TRNA LIGASE; 1.
DR PANTHER; PTHR11476; HISTIDYL-TRNA SYNTHETASE; 1.
DR Pfam; PF13393; tRNA-synt_His; 1.
DR SUPFAM; SSF52954; Class II aaRS ABD-related; 1.
DR SUPFAM; SSF55681; Class II aaRS and biotin synthetases; 1.
DR PROSITE; PS50862; AA_TRNA_LIGASE_II; 1.
PE 3: Inferred from homology;
KW Aminoacyl-tRNA synthetase {ECO:0000313|EMBL:EDO81376.1};
KW Ligase {ECO:0000313|EMBL:EDO81376.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001548}.
FT DOMAIN 438..794
FT /note="Aminoacyl-transfer RNA synthetases class-II family
FT profile"
FT /evidence="ECO:0000259|PROSITE:PS50862"
SQ SEQUENCE 961 AA; 105284 MW; A51CA94D10E3879B CRC64;
MLPVVELGGT SLTLESFYNV CYCRAPIVLD ASVFAAFLPA PENPVPRAPY HYATLFSGKY
RSVPYVLSRA YIFTMLSLLA SSPASVSITV LQGLTRILNG PKDIALQRPE CVLLPNSALE
KDLLDQLLSI LTEGPDNPFY IELSDEDINI FKLNAHAFTL SVSFASSILL SFVATLHEAA
LSFSFELMCA RVRELFDFVN YTVQRKHSGM KAAMSNVMSL ISGSKKVTQK GSNLFCSQSL
SLAGEIRELA TELRTAVRPD TASAAYTSLD TRPLTDVTTL SLLHGVQLKI ATIRSLSIAR
RHLVDAVVVE KGIWKAPSDD AYGVAESEML DALKKEPVPV LHALLLPVQL CGVLKDLSTE
LLSAFTKLSI AQAGLSKGKI QVGQGVLIAM DTYGDLFREC QSASGAHQFW CISRIVRAMT
DHLFLAISNA RIPQPPCGMR DLLPGQMVLR QAALSLITSV FQQHGAVCIE TPVMESRSVL
MGKYGEEQKL IYNVSDYGEE PLSLRYDLTV PFARYCATHR EKSIKRYSIG RVYRRDKPVM
EKGRFREFYQ CDLDIVYEPN TQAPMAADAE VVVIVFEILH ALRKSIRNFE ILINHRGILD
SAMAVAGVSD EQKKAVCSCI DQLDKHSKEE VRDKIVKSKG LTPVVADTVL ALIDFKLPTS
PHMFANSPFD FVSTAIAALK ELHASISLDS TLSSQFIDAI SPRLEQLGLL FRYASLMCPQ
SLEYMVLDFS LARGLDYYTG MVFEAKLISD HGERTGSIAG GGRYDELLGK FRARGDELCA
VGGSIGIERI FAILEARQAS LDGLATGDVE DGGSSCKLAS AKRYDVYICG APGCTIEARL
EVAGILWGLG ISVGMSCKEG CSQKLLKKDI DEGVAGHALL ALIIGGDEIE NRVINVKNLS
TTEQVVVPFD EIGEYCAKAL ATRHERFALS ECEKLLRDVK DGKEVREGID NILAAIKMLR
T
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