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Database: UniProt
Entry: A8BA83_TRIHA
LinkDB: A8BA83_TRIHA
Original site: A8BA83_TRIHA 
ID   A8BA83_TRIHA            Unreviewed;       154 AA.
AC   A8BA83;
DT   13-NOV-2007, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2007, sequence version 1.
DT   10-APR-2019, entry version 59.
DE   RecName: Full=Superoxide dismutase [Cu-Zn] {ECO:0000256|RuleBase:RU000393};
DE            EC=1.15.1.1 {ECO:0000256|RuleBase:RU000393};
GN   Name=sod1 {ECO:0000313|EMBL:AYD59709.1};
GN   ORFNames=CI102_4503 {ECO:0000313|EMBL:PKK52705.1}, THAR02_08119
GN   {ECO:0000313|EMBL:KKO99769.1};
OS   Trichoderma harzianum (Hypocrea lixii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
OC   Sordariomycetes; Hypocreomycetidae; Hypocreales; Hypocreaceae;
OC   Trichoderma.
OX   NCBI_TaxID=5544 {ECO:0000313|EMBL:ABL75447.1};
RN   [1] {ECO:0000313|EMBL:ABL75447.1}
RP   NUCLEOTIDE SEQUENCE.
RX   AGRICOLA=IND44314643; DOI=10.1007/s11274-009-0182-4;
RA   Yang L., Yang Q., Sun K., Tan Y., Li H.;
RT   "Agrobacterium tumefaciens-mediated transformation of SOD gene to
RT   Trichoderma harzianum.";
RL   World J. Microbiol. Biotechnol. 26:353-358(2010).
RN   [2] {ECO:0000313|EMBL:PKK52705.1, ECO:0000313|Proteomes:UP000233603}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TR274 {ECO:0000313|EMBL:PKK52705.1,
RC   ECO:0000313|Proteomes:UP000233603};
RX   PubMed=24635846; DOI=10.1186/1471-2164-15-204;
RA   Steindorff A.S., Ramada M.H., Coelho A.S., Miller R.N.,
RA   Pappas G.J.Jr., Ulhoa C.J., Noronha E.F.;
RT   "Identification of mycoparasitism-related genes against the
RT   phytopathogen Sclerotinia sclerotiorum through transcriptome and
RT   expression profile analysis in Trichoderma harzianum.";
RL   BMC Genomics 15:204-204(2014).
RN   [3] {ECO:0000313|EMBL:AGN54388.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=T28 {ECO:0000313|EMBL:AGN54388.1};
RX   PubMed=24964161;
RA   Yu C., Fan L., Wu Q., Fu K., Gao S., Wang M., Gao J., Li Y., Chen J.;
RT   "Biological Role of Trichoderma harzianum-Derived Platelet-Activating
RT   Factor Acetylhydrolase (PAF-AH) on Stress Response and Antagonism.";
RL   PLoS ONE 9:E100367-E100367(2014).
RN   [4] {ECO:0000313|EMBL:KKO99769.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=T6776 {ECO:0000313|EMBL:KKO99769.1};
RA   Baroncelli R., Vannacci G.;
RT   "The genome sequence of Trichoderma harzianum T6776.";
RL   Submitted (JUN-2014) to the EMBL/GenBank/DDBJ databases.
RN   [5] {ECO:0000313|Proteomes:UP000034112}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=T6776 {ECO:0000313|Proteomes:UP000034112};
RX   PubMed=26067977; DOI=10.1128/genomeA.00647-15;
RA   Baroncelli R., Piaggeschi G., Fiorini L., Bertolini E., Zapparata A.,
RA   Pe M.E., Sarrocco S., Vannacci G.;
RT   "Draft whole-genome sequence of the biocontrol agent Trichoderma
RT   harzianum T6776.";
RL   Genome Announc. 3:E0064715-E0064715(2015).
RN   [6] {ECO:0000313|EMBL:PKK52705.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=TR274 {ECO:0000313|EMBL:PKK52705.1};
RA   de Groot N.N.;
RL   Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
RN   [7] {ECO:0000313|EMBL:AYD59709.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Mei J.;
RT   "Functional study on copper metabolism related gene THMEA1 of
RT   Trichoderma harzianum Th33.";
RL   Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Destroys radicals which are normally produced within the
CC       cells and which are toxic to biological systems.
CC       {ECO:0000256|RuleBase:RU000393}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 H(+) + 2 superoxide = H2O2 + O2; Xref=Rhea:RHEA:20696,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240,
CC         ChEBI:CHEBI:18421; EC=1.15.1.1;
CC         Evidence={ECO:0000256|RuleBase:RU000393};
CC   -!- COFACTOR:
CC       Name=Cu cation; Xref=ChEBI:CHEBI:23378;
CC         Evidence={ECO:0000256|RuleBase:RU000393};
CC       Note=Binds 1 copper ion per subunit.
CC       {ECO:0000256|RuleBase:RU000393};
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|RuleBase:RU000393};
CC       Note=Binds 1 zinc ion per subunit.
CC       {ECO:0000256|RuleBase:RU000393};
CC   -!- SIMILARITY: Belongs to the Cu-Zn superoxide dismutase family.
CC       {ECO:0000256|RuleBase:RU000393}.
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DR   EMBL; EF028237; ABL75447.1; -; mRNA.
DR   EMBL; JX481779; AGN54388.1; -; mRNA.
DR   EMBL; MG431814; AYD59709.1; -; mRNA.
DR   EMBL; JOKZ01000300; KKO99769.1; -; Genomic_DNA.
DR   EMBL; NQLC01000068; PKK52705.1; -; Genomic_DNA.
DR   EnsemblFungi; KKO99769; KKO99769; THAR02_08119.
DR   OrthoDB; 1574423at2759; -.
DR   Proteomes; UP000034112; Unassembled WGS sequence.
DR   Proteomes; UP000233603; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004784; F:superoxide dismutase activity; IEA:UniProtKB-EC.
DR   GO; GO:0045454; P:cell redox homeostasis; IEA:EnsemblFungi.
DR   GO; GO:0006882; P:cellular zinc ion homeostasis; IEA:EnsemblFungi.
DR   CDD; cd00305; Cu-Zn_Superoxide_Dismutase; 1.
DR   Gene3D; 2.60.40.200; -; 1.
DR   InterPro; IPR036423; SOD-like_Cu/Zn_dom_sf.
DR   InterPro; IPR024134; SOD_Cu/Zn_/chaperone.
DR   InterPro; IPR018152; SOD_Cu/Zn_BS.
DR   InterPro; IPR001424; SOD_Cu_Zn_dom.
DR   PANTHER; PTHR10003; PTHR10003; 1.
DR   Pfam; PF00080; Sod_Cu; 1.
DR   PRINTS; PR00068; CUZNDISMTASE.
DR   SUPFAM; SSF49329; SSF49329; 1.
DR   PROSITE; PS00087; SOD_CU_ZN_1; 1.
DR   PROSITE; PS00332; SOD_CU_ZN_2; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000034112,
KW   ECO:0000313|Proteomes:UP000233603};
KW   Copper {ECO:0000256|RuleBase:RU000393};
KW   Metal-binding {ECO:0000256|RuleBase:RU000393};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU000393};
KW   Reference proteome {ECO:0000313|Proteomes:UP000034112};
KW   Zinc {ECO:0000256|RuleBase:RU000393}.
FT   DOMAIN       11    150       Sod_Cu. {ECO:0000259|Pfam:PF00080}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:AYD59709.1}.
FT   NON_TER     154    154       {ECO:0000313|EMBL:PKK52705.1}.
SQ   SEQUENCE   154 AA;  15767 MW;  B6A9A03836FF4D2D CRC64;
     MVKAVTVLRG DAKVSGTVIF EQASEGAPTT ITYDITGNDA NAKRGFHIHT FGDNTNGCTS
     AGPHFNPFNK THGSPSDEAR HVGDLGNIET DAQGNAKGTI TDSLVQLIGP NSVIGRTVVV
     HAGTDDLGKG DNEESLKTGN AGPRPACGVI GISA
//
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