ID A8BAD5_GIAIC Unreviewed; 406 AA.
AC A8BAD5;
DT 13-NOV-2007, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2007, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Embryo-related protein {ECO:0000313|EMBL:EDO80695.1};
DE SubName: Full=tRNA-dihydrouridine synthase 1 {ECO:0000313|EMBL:KAE8303525.1};
GN ORFNames=GL50803_008705 {ECO:0000313|EMBL:KAE8303525.1}, GL50803_8705
GN {ECO:0000313|EMBL:EDO80695.1};
OS Giardia intestinalis (strain ATCC 50803 / WB clone C6) (Giardia lamblia).
OC Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX NCBI_TaxID=184922 {ECO:0000313|EMBL:EDO80695.1};
RN [1] {ECO:0000313|EMBL:EDO80695.1, ECO:0000313|Proteomes:UP000001548}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50803 / WB clone C6 {ECO:0000313|Proteomes:UP000001548},
RC and WB C6 {ECO:0000313|EMBL:EDO80695.1};
RX PubMed=17901334; DOI=10.1126/science.1143837;
RA Morrison H.G., McArthur A.G., Gillin F.D., Aley S.B., Adam R.D.,
RA Olsen G.J., Best A.A., Cande W.Z., Chen F., Cipriano M.J., Davids B.J.,
RA Dawson S.C., Elmendorf H.G., Hehl A.B., Holder M.E., Huse S.M., Kim U.U.,
RA Lasek-Nesselquist E., Manning G., Nigam A., Nixon J.E., Palm D.,
RA Passamaneck N.E., Prabhu A., Reich C.I., Reiner D.S., Samuelson J.,
RA Svard S.G., Sogin M.L.;
RT "Genomic minimalism in the early diverging intestinal parasite Giardia
RT lamblia.";
RL Science 317:1921-1926(2007).
RN [2] {ECO:0000313|EMBL:KAE8303525.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=WB C6 {ECO:0000313|EMBL:KAE8303525.1};
RA Xu F., Jex A., Svard S.G.;
RT "New Giardia intestinalis WB genome in near-complete chromosomes.";
RL Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDO80695.1}.
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DR EMBL; AACB02000008; EDO80695.1; -; Genomic_DNA.
DR EMBL; AACB03000002; KAE8303525.1; -; Genomic_DNA.
DR RefSeq; XP_001708369.1; XM_001708317.1.
DR AlphaFoldDB; A8BAD5; -.
DR STRING; 184922.A8BAD5; -.
DR EnsemblProtists; EDO80695; EDO80695; GL50803_8705.
DR GeneID; 5701280; -.
DR KEGG; gla:GL50803_008705; -.
DR VEuPathDB; GiardiaDB:GL50803_8705; -.
DR HOGENOM; CLU_678715_0_0_1; -.
DR InParanoid; A8BAD5; -.
DR OMA; FSAPMTH; -.
DR Proteomes; UP000001548; Chromosome 4.
DR GO; GO:0017150; F:tRNA dihydrouridine synthase activity; IBA:GO_Central.
DR CDD; cd02801; DUS_like_FMN; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR035587; DUS-like_FMN-bd.
DR PANTHER; PTHR11082; TRNA-DIHYDROURIDINE SYNTHASE; 1.
DR PANTHER; PTHR11082:SF5; TRNA-DIHYDROURIDINE(16_17) SYNTHASE [NAD(P)(+)]-LIKE; 1.
DR Pfam; PF01207; Dus; 2.
DR SUPFAM; SSF51395; FMN-linked oxidoreductases; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001548}.
FT DOMAIN 56..245
FT /note="DUS-like FMN-binding"
FT /evidence="ECO:0000259|Pfam:PF01207"
FT DOMAIN 273..318
FT /note="DUS-like FMN-binding"
FT /evidence="ECO:0000259|Pfam:PF01207"
SQ SEQUENCE 406 AA; 44896 MW; 2D05160734AE5448 CRC64;
MDYREWVNKG VPPCKNCPLE SVQELPADFP FFSVSAFNDA VIQLRSRLAE TRYFSAPMTH
ASGAAFRQLI QGHMAEENER TKYTGFTQMY TADALLHNSP LRDAVLSTAA PGEKIILQLC
GNNPSTFRAA AELLHDSPIA SQLVALDINL GCPASCASSK GYGFYVAQNW PLVHQIISET
SSARLFPVTC KIRPLNSIEK TIDYMVLLVM SGASGITIHM RHTTRQGKHA QAVRPAYQEF
EELVRAFRQR LDTLFTGLGG SETAQENPHV YPVIILNGGI KNRQEADHLL ATYPADGVML
GVGLLKNPAC LLKNAPQIPG KNRIAFWVNE ALKYLDLCES LSQESIGQEN PLKVTPMASH
KEIIGHTMRL MQNVSAKRFN EPINRAKSIA ELREFLTKVL CAQASD
//
