ID A8BB65_GIAIC Unreviewed; 128 AA.
AC A8BB65;
DT 13-NOV-2007, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2007, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Zinc finger domain protein {ECO:0000313|EMBL:EDO80545.1};
GN ORFNames=GL50803_0016877 {ECO:0000313|EMBL:KAE8302073.1},
GN GL50803_16877 {ECO:0000313|EMBL:EDO80545.1};
OS Giardia intestinalis (strain ATCC 50803 / WB clone C6) (Giardia lamblia).
OC Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX NCBI_TaxID=184922 {ECO:0000313|EMBL:EDO80545.1};
RN [1] {ECO:0000313|EMBL:EDO80545.1, ECO:0000313|Proteomes:UP000001548}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50803 / WB clone C6 {ECO:0000313|Proteomes:UP000001548},
RC and WB C6 {ECO:0000313|EMBL:EDO80545.1};
RX PubMed=17901334; DOI=10.1126/science.1143837;
RA Morrison H.G., McArthur A.G., Gillin F.D., Aley S.B., Adam R.D.,
RA Olsen G.J., Best A.A., Cande W.Z., Chen F., Cipriano M.J., Davids B.J.,
RA Dawson S.C., Elmendorf H.G., Hehl A.B., Holder M.E., Huse S.M., Kim U.U.,
RA Lasek-Nesselquist E., Manning G., Nigam A., Nixon J.E., Palm D.,
RA Passamaneck N.E., Prabhu A., Reich C.I., Reiner D.S., Samuelson J.,
RA Svard S.G., Sogin M.L.;
RT "Genomic minimalism in the early diverging intestinal parasite Giardia
RT lamblia.";
RL Science 317:1921-1926(2007).
RN [2] {ECO:0000313|EMBL:KAE8302073.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=WB C6 {ECO:0000313|EMBL:KAE8302073.1};
RA Xu F., Jex A., Svard S.G.;
RT "New Giardia intestinalis WB genome in near-complete chromosomes.";
RL Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the ZNF593/BUD20 C2H2-type zinc-finger protein
CC family. {ECO:0000256|ARBA:ARBA00038064}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDO80545.1}.
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DR EMBL; AACB02000009; EDO80545.1; -; Genomic_DNA.
DR EMBL; AACB03000004; KAE8302073.1; -; Genomic_DNA.
DR RefSeq; XP_001708219.1; XM_001708167.1.
DR AlphaFoldDB; A8BB65; -.
DR STRING; 184922.A8BB65; -.
DR EnsemblProtists; EDO80545; EDO80545; GL50803_16877.
DR GeneID; 5701128; -.
DR KEGG; gla:GL50803_0016877; -.
DR VEuPathDB; GiardiaDB:GL50803_16877; -.
DR HOGENOM; CLU_117291_1_2_1; -.
DR InParanoid; A8BB65; -.
DR OMA; MKDHFRS; -.
DR Proteomes; UP000001548; Chromosome 2.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR InterPro; IPR003604; Matrin/U1-like-C_Znf_C2H2.
DR InterPro; IPR022755; Znf_C2H2_jaz.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR46095; ZINC FINGER PROTEIN 593; 1.
DR PANTHER; PTHR46095:SF1; ZINC FINGER PROTEIN 593; 1.
DR Pfam; PF12171; zf-C2H2_jaz; 1.
DR SMART; SM00451; ZnF_U1; 1.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001548};
KW Ribosome biogenesis {ECO:0000256|ARBA:ARBA00022517};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 61..83
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS00028"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 128 AA; 14672 MW; 9690B9E7675A6381 CRC64;
MGGATRKKNK TNHREVSRRV KTKRRTKDVD EILEMLSPEN VEKIKNRDPD PLLPGDGMHF
CIICDRYFIS AEALETHKAT GKHKFQVKRV REGGISPKET ELFARRGLPD NGRKIVRDEN
GELIGFTD
//
