ID A8BBB3_GIAIC Unreviewed; 788 AA.
AC A8BBB3;
DT 13-NOV-2007, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2007, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Amino acid transporter family {ECO:0000313|EMBL:EDO80578.1};
GN ORFNames=GL50803_008523 {ECO:0000313|EMBL:KAE8302042.1}, GL50803_8523
GN {ECO:0000313|EMBL:EDO80578.1};
OS Giardia intestinalis (strain ATCC 50803 / WB clone C6) (Giardia lamblia).
OC Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX NCBI_TaxID=184922 {ECO:0000313|EMBL:EDO80578.1};
RN [1] {ECO:0000313|EMBL:EDO80578.1, ECO:0000313|Proteomes:UP000001548}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50803 / WB clone C6 {ECO:0000313|Proteomes:UP000001548},
RC and WB C6 {ECO:0000313|EMBL:EDO80578.1};
RX PubMed=17901334; DOI=10.1126/science.1143837;
RA Morrison H.G., McArthur A.G., Gillin F.D., Aley S.B., Adam R.D.,
RA Olsen G.J., Best A.A., Cande W.Z., Chen F., Cipriano M.J., Davids B.J.,
RA Dawson S.C., Elmendorf H.G., Hehl A.B., Holder M.E., Huse S.M., Kim U.U.,
RA Lasek-Nesselquist E., Manning G., Nigam A., Nixon J.E., Palm D.,
RA Passamaneck N.E., Prabhu A., Reich C.I., Reiner D.S., Samuelson J.,
RA Svard S.G., Sogin M.L.;
RT "Genomic minimalism in the early diverging intestinal parasite Giardia
RT lamblia.";
RL Science 317:1921-1926(2007).
RN [2] {ECO:0000313|EMBL:KAE8302042.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=WB C6 {ECO:0000313|EMBL:KAE8302042.1};
RA Xu F., Jex A., Svard S.G.;
RT "New Giardia intestinalis WB genome in near-complete chromosomes.";
RL Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDO80578.1}.
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DR EMBL; AACB02000009; EDO80578.1; -; Genomic_DNA.
DR EMBL; AACB03000004; KAE8302042.1; -; Genomic_DNA.
DR RefSeq; XP_001708252.1; XM_001708200.1.
DR AlphaFoldDB; A8BBB3; -.
DR STRING; 184922.A8BBB3; -.
DR EnsemblProtists; EDO80578; EDO80578; GL50803_8523.
DR GeneID; 5701162; -.
DR KEGG; gla:GL50803_008523; -.
DR VEuPathDB; GiardiaDB:GL50803_8523; -.
DR HOGENOM; CLU_363485_0_0_1; -.
DR InParanoid; A8BBB3; -.
DR OMA; GCQISIA; -.
DR Proteomes; UP000001548; Chromosome 2.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0015179; F:L-amino acid transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0003333; P:amino acid transmembrane transport; IBA:GO_Central.
DR InterPro; IPR013057; AA_transpt_TM.
DR PANTHER; PTHR22950:SF710; ACID TRANSPORTER, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR22950; AMINO ACID TRANSPORTER; 1.
DR Pfam; PF01490; Aa_trans; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001548};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 68..94
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 115..135
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 155..173
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 185..206
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 285..303
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 315..339
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 359..381
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 402..422
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 428..450
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 755..779
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 42..208
FT /note="Amino acid transporter transmembrane"
FT /evidence="ECO:0000259|Pfam:PF01490"
FT DOMAIN 280..460
FT /note="Amino acid transporter transmembrane"
FT /evidence="ECO:0000259|Pfam:PF01490"
SQ SEQUENCE 788 AA; 88023 MW; 56382ABDC2615349 CRC64;
MDTEQDQSKL VCTTHENAAV PSGPEGPKQA EKVASDAKGL YDATVTLSNT MIGVSILTFP
YTVYRLGWVI SAVLLAGAFL YSVLGFNAII DAAYFTQERS LKAIVQIVTN KHTAITTDVV
MIIHMIGVLV VYTSICGDYF HSSIVGFSYG KFQLDARYVK VIVAILLVPF MFLRDASKLS
RIGIFSTLFI MITVASTAVY FIVFMIRGTV TYAGTVEGAI VELKDPHGHM TTSSKATISS
LISPLGTIIE CPTEGCKMKF PNPLLIAFPA HTIPWQAFLE IVRRVSIFLA LFGCQISIAP
LLAELKGSPV KRRRIFRKSL FISALMVLIL QVIMAVAAAF SFGDKLQSNV LLSFPSVEIY
MTVIKLLYAC VLFIIFVLKM FPIRYVILGW FRLTIDTRKG KIIFYILGLL IVTMATLLSI
FVPNIDTVFN AISALFGIVT YWLVPLLLVY KRPYLEATSV NTLLGEPTKG SKKRRHQNRV
LVDDHENQQL LEEDDVAVES GVRYSREPHR HHGHSQVEET SVDQVGVGFL AFFGFSIKQA
RAFTKVFRAA HPMQERLLTR QDRHIIKHHE IWHNRACSLP ASEAGSEEIE SAHQMVQEVI
SCEYIDDGTR TGEMESSASH AIAIYKIRKM QEEQQHLLSD TEDRTCTKDG SRPPAKALRT
IMTMRKRRNS VSESNPAQDY CLLQDTIPPN TLPRGPYANA AAAIRNQETK DQGDTNPRTV
HDELLVAGGH ETIQSINKEE ERRYALKKKM TRTRLALAIC ATVLIGAINL TGFVLSTFVD
TETFNWIF
//
