ID A8BCL1_GIAIC Unreviewed; 264 AA.
AC A8BCL1;
DT 13-NOV-2007, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2007, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Nitroreductase Fd-NR2 {ECO:0000313|EMBL:EDO80257.1};
GN ORFNames=GL50803_0022677 {ECO:0000313|EMBL:KAE8301349.1},
GN GL50803_22677 {ECO:0000313|EMBL:EDO80257.1};
OS Giardia intestinalis (strain ATCC 50803 / WB clone C6) (Giardia lamblia).
OC Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX NCBI_TaxID=184922 {ECO:0000313|EMBL:EDO80257.1};
RN [1] {ECO:0000313|EMBL:EDO80257.1, ECO:0000313|Proteomes:UP000001548}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50803 / WB clone C6 {ECO:0000313|Proteomes:UP000001548},
RC and WB C6 {ECO:0000313|EMBL:EDO80257.1};
RX PubMed=17901334; DOI=10.1126/science.1143837;
RA Morrison H.G., McArthur A.G., Gillin F.D., Aley S.B., Adam R.D.,
RA Olsen G.J., Best A.A., Cande W.Z., Chen F., Cipriano M.J., Davids B.J.,
RA Dawson S.C., Elmendorf H.G., Hehl A.B., Holder M.E., Huse S.M., Kim U.U.,
RA Lasek-Nesselquist E., Manning G., Nigam A., Nixon J.E., Palm D.,
RA Passamaneck N.E., Prabhu A., Reich C.I., Reiner D.S., Samuelson J.,
RA Svard S.G., Sogin M.L.;
RT "Genomic minimalism in the early diverging intestinal parasite Giardia
RT lamblia.";
RL Science 317:1921-1926(2007).
RN [2] {ECO:0000313|EMBL:KAE8301349.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=WB C6 {ECO:0000313|EMBL:KAE8301349.1};
RA Xu F., Jex A., Svard S.G.;
RT "New Giardia intestinalis WB genome in near-complete chromosomes.";
RL Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the nitroreductase family.
CC {ECO:0000256|ARBA:ARBA00007118}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDO80257.1}.
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DR EMBL; AACB02000011; EDO80257.1; -; Genomic_DNA.
DR EMBL; AACB03000005; KAE8301349.1; -; Genomic_DNA.
DR RefSeq; XP_001707931.1; XM_001707879.1.
DR AlphaFoldDB; A8BCL1; -.
DR SMR; A8BCL1; -.
DR STRING; 184922.A8BCL1; -.
DR EnsemblProtists; EDO80257; EDO80257; GL50803_22677.
DR GeneID; 5700840; -.
DR KEGG; gla:GL50803_0022677; -.
DR VEuPathDB; GiardiaDB:GL50803_22677; -.
DR HOGENOM; CLU_070764_2_0_1; -.
DR InParanoid; A8BCL1; -.
DR OMA; ICRNAPH; -.
DR Proteomes; UP000001548; Chromosome 1.
DR GO; GO:0016491; F:oxidoreductase activity; IBA:GO_Central.
DR CDD; cd02143; nitroreductase_FeS-like; 1.
DR Gene3D; 3.30.70.20; -; 1.
DR Gene3D; 3.40.109.10; NADH Oxidase; 1.
DR InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR InterPro; IPR017900; 4Fe4S_Fe_S_CS.
DR InterPro; IPR029479; Nitroreductase.
DR InterPro; IPR000415; Nitroreductase-like.
DR PANTHER; PTHR23026:SF90; IODOTYROSINE DEIODINASE 1; 1.
DR PANTHER; PTHR23026; NADPH NITROREDUCTASE; 1.
DR Pfam; PF12838; Fer4_7; 1.
DR Pfam; PF00881; Nitroreductase; 1.
DR SUPFAM; SSF54862; 4Fe-4S ferredoxins; 1.
DR SUPFAM; SSF55469; FMN-dependent nitroreductase-like; 1.
DR PROSITE; PS00198; 4FE4S_FER_1; 2.
DR PROSITE; PS51379; 4FE4S_FER_2; 2.
PE 3: Inferred from homology;
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Reference proteome {ECO:0000313|Proteomes:UP000001548}.
FT DOMAIN 4..33
FT /note="4Fe-4S ferredoxin-type"
FT /evidence="ECO:0000259|PROSITE:PS51379"
FT DOMAIN 36..65
FT /note="4Fe-4S ferredoxin-type"
FT /evidence="ECO:0000259|PROSITE:PS51379"
SQ SEQUENCE 264 AA; 28552 MW; E0B5B4F783749F11 CRC64;
MVEGYPVFLT DTCTGCNMCV EVCPTAVLKV DPETKVVAYA NRDNCIFCGH CGAICPTESI
SMFGITPESE ENAIKTDPPA VRAVKMARTC RKYHPEPLPK EDLMQALSIA KYSASSSNIR
PLHFTVLSRS LMDTLSLSIA KEVSKNPRYS KVAALVEKGI DVVFRGAPHM ILMSAPADKA
AVAMADASIA GRDIQLNAES MGLGMFWCGF LLAAVASSQE LHDICGVPEG HKILMAMGIG
RPKVKFARPA LRRNLEEGVD ITFK
//
