ID A8BE44_GIAIC Unreviewed; 974 AA.
AC A8BE44;
DT 13-NOV-2007, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2007, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=CLASP N terminal domain-containing protein {ECO:0000313|EMBL:KAE8305841.1};
GN ORFNames=GL50803_006735 {ECO:0000313|EMBL:KAE8305841.1}, GL50803_6735
GN {ECO:0000313|EMBL:EDO79911.1};
OS Giardia intestinalis (strain ATCC 50803 / WB clone C6) (Giardia lamblia).
OC Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX NCBI_TaxID=184922 {ECO:0000313|EMBL:EDO79911.1};
RN [1] {ECO:0000313|EMBL:EDO79911.1, ECO:0000313|Proteomes:UP000001548}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50803 / WB clone C6 {ECO:0000313|Proteomes:UP000001548},
RC and WB C6 {ECO:0000313|EMBL:EDO79911.1};
RX PubMed=17901334; DOI=10.1126/science.1143837;
RA Morrison H.G., McArthur A.G., Gillin F.D., Aley S.B., Adam R.D.,
RA Olsen G.J., Best A.A., Cande W.Z., Chen F., Cipriano M.J., Davids B.J.,
RA Dawson S.C., Elmendorf H.G., Hehl A.B., Holder M.E., Huse S.M., Kim U.U.,
RA Lasek-Nesselquist E., Manning G., Nigam A., Nixon J.E., Palm D.,
RA Passamaneck N.E., Prabhu A., Reich C.I., Reiner D.S., Samuelson J.,
RA Svard S.G., Sogin M.L.;
RT "Genomic minimalism in the early diverging intestinal parasite Giardia
RT lamblia.";
RL Science 317:1921-1926(2007).
RN [2] {ECO:0000313|EMBL:KAE8305841.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=WB C6 {ECO:0000313|EMBL:KAE8305841.1};
RA Xu F., Jex A., Svard S.G.;
RT "New Giardia intestinalis WB genome in near-complete chromosomes.";
RL Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDO79911.1}.
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DR EMBL; AACB02000013; EDO79911.1; -; Genomic_DNA.
DR EMBL; AACB03000001; KAE8305841.1; -; Genomic_DNA.
DR RefSeq; XP_001707585.1; XM_001707533.1.
DR AlphaFoldDB; A8BE44; -.
DR STRING; 184922.A8BE44; -.
DR EnsemblProtists; EDO79911; EDO79911; GL50803_6735.
DR GeneID; 5700487; -.
DR KEGG; gla:GL50803_006735; -.
DR VEuPathDB; GiardiaDB:GL50803_6735; -.
DR HOGENOM; CLU_304931_0_0_1; -.
DR InParanoid; A8BE44; -.
DR OMA; KNEANWT; -.
DR Proteomes; UP000001548; Chromosome 5.
DR GO; GO:0005881; C:cytoplasmic microtubule; IBA:GO_Central.
DR GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR GO; GO:0000226; P:microtubule cytoskeleton organization; IBA:GO_Central.
DR GO; GO:0031110; P:regulation of microtubule polymerization or depolymerization; IEA:UniProt.
DR GO; GO:1902903; P:regulation of supramolecular fiber organization; IEA:UniProt.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 3.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR034085; TOG.
DR PANTHER; PTHR21567; CLASP; 1.
DR PANTHER; PTHR21567:SF9; CLIP-ASSOCIATING PROTEIN; 1.
DR SMART; SM01349; TOG; 2.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50077; HEAT_REPEAT; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001548};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 2..223
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REPEAT 165..201
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT DOMAIN 737..971
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REGION 201..284
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 670..719
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 220..284
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 670..705
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 974 AA; 107148 MW; 434100C20012C335 CRC64;
MPLDPQVAES LSVGPTAERF KALEKFIGML KSGETVAPDN VSVFVDALTG NFDDTNFKVV
TYSLEAVQII LSRNTAFLTK TYGQRLLSST LDKFGHVRPS VKECAYSLAY FLMKSTVVSD
FDINLGVCMT ALAHKNAGVR ETTIQLLSTI LLELGKPDVK ALAKVVPRFT ELTKDSSPVV
RSQATVALAN LTEEYPDSLA RLAGQSGGDK DKESRDHGIQ KPTSSGVNRS GVRRETSASN
IPGRSGIGGT GGSIPSATDT AISLFPPPST QDPDGQSNPL SIVPPTQQAS YYPYRPLYSY
DLLFSPNSLV SAGTDLTQKK FHSILRLEEQ KMVDELNAIF SVFSANLKNE ANWTIQLDTV
KALISLIIID SEAGVTLSTQ IFAQTFTDFL SQNLAQIVAC VMSRRSILSR EMCIFLELYA
QRYGTYGTRF VVDLIDPLIR LLNQKGACYE TSADATMRAI IVYCNPKMAL ARLVKHGQAD
KSSHVRAHVI EYILLLFISA CLHSEGYLAG RGFCSEIDFW LRHEADIIQL FCKLADDALQ
RTRITAKCAL LVMRILRLSF WSKSSQLLGS KAPKIEASVR ETCLSYYYIS GKTHKTKRVP
LASDDFLMEW LRSASRFAYV KCMDIDFNWK VLLIETIDKF IGWSSVGGLP SGFTDALGCQ
DVAVEQVSST STGALPHASS SQQSSRISRK TPISATASSE RGKTVSATAR PEHNGPVHTA
AKQASTIAYD DLDDVDELVT NTQTATRLNG ILSNLALSTQ PDNVLLSLMK QWTNSFPELQ
SELRRSYAQA ILVLLDLTKH SSLAVRLEAL GIIRLIVVSD GALLEDILDV FLLPILEIYK
DPELIVRRAA DAVLLLLPTV LPVRNVFKGY SSIVNTAADV VLHGSLRLLA KTSHFYKDNA
LLLEDIDSVF PGLMRAFSNE NPDIRKAVVY CLVDLYYLVG EDFTPYLNRL SASQLKLVTI
YVVKMSEKRA KQGC
//
