ID A8BG37_GIAIC Unreviewed; 163 AA.
AC A8BG37;
DT 13-NOV-2007, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2007, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=ARF GAP {ECO:0000313|EMBL:EDO79449.1};
DE SubName: Full=GTPase activating protein for ARF {ECO:0000313|EMBL:KAE8302226.1};
GN ORFNames=GL50803_0022454 {ECO:0000313|EMBL:KAE8302226.1},
GN GL50803_22454 {ECO:0000313|EMBL:EDO79449.1};
OS Giardia intestinalis (strain ATCC 50803 / WB clone C6) (Giardia lamblia).
OC Eukaryota; Metamonada; Diplomonadida; Hexamitidae; Giardiinae; Giardia.
OX NCBI_TaxID=184922 {ECO:0000313|EMBL:EDO79449.1};
RN [1] {ECO:0000313|EMBL:EDO79449.1, ECO:0000313|Proteomes:UP000001548}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 50803 / WB clone C6 {ECO:0000313|Proteomes:UP000001548},
RC and WB C6 {ECO:0000313|EMBL:EDO79449.1};
RX PubMed=17901334; DOI=10.1126/science.1143837;
RA Morrison H.G., McArthur A.G., Gillin F.D., Aley S.B., Adam R.D.,
RA Olsen G.J., Best A.A., Cande W.Z., Chen F., Cipriano M.J., Davids B.J.,
RA Dawson S.C., Elmendorf H.G., Hehl A.B., Holder M.E., Huse S.M., Kim U.U.,
RA Lasek-Nesselquist E., Manning G., Nigam A., Nixon J.E., Palm D.,
RA Passamaneck N.E., Prabhu A., Reich C.I., Reiner D.S., Samuelson J.,
RA Svard S.G., Sogin M.L.;
RT "Genomic minimalism in the early diverging intestinal parasite Giardia
RT lamblia.";
RL Science 317:1921-1926(2007).
RN [2] {ECO:0000313|EMBL:KAE8302226.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=WB C6 {ECO:0000313|EMBL:KAE8302226.1};
RA Xu F., Jex A., Svard S.G.;
RT "New Giardia intestinalis WB genome in near-complete chromosomes.";
RL Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDO79449.1}.
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DR EMBL; AACB02000016; EDO79449.1; -; Genomic_DNA.
DR EMBL; AACB03000004; KAE8302226.1; -; Genomic_DNA.
DR RefSeq; XP_001707123.1; XM_001707071.1.
DR AlphaFoldDB; A8BG37; -.
DR STRING; 184922.A8BG37; -.
DR EnsemblProtists; EDO79449; EDO79449; GL50803_22454.
DR GeneID; 5700009; -.
DR KEGG; gla:GL50803_0022454; -.
DR VEuPathDB; GiardiaDB:GL50803_22454; -.
DR HOGENOM; CLU_1630157_0_0_1; -.
DR InParanoid; A8BG37; -.
DR OMA; TWASIKL; -.
DR Proteomes; UP000001548; Chromosome 2.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR CDD; cd08831; ArfGap_ArfGap2_3_like; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR PANTHER; PTHR45686; ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H-RELATED; 1.
DR Pfam; PF01412; ArfGap; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00105; ArfGap; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR PROSITE; PS50115; ARFGAP; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00288}; Reference proteome {ECO:0000313|Proteomes:UP000001548};
KW Zinc {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-ProRule:PRU00288};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00288}.
FT DOMAIN 8..118
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT REGION 115..139
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 163 AA; 18460 MW; 1B83FC51670A0B58 CRC64;
MESDLLRDRL LAAQKALGPT CFDCGAKNPT WASIKLGIFL CMNCAGRHRS YGTHISFIRS
LTLDKWTEDQ VRLVEVGGNN AFRQYLQQEG ISHPLQYQQT DLGPYRELLQ ERASASYRNT
DPEKQPWSGS SGLKTKAQPQ AVVNTMVEDS PYRRTLGRIV RLE
//
